Results 41 to 50 of about 12,579,753 (296)

FLORA: a novel method to predict protein function from structure in diverse superfamilies [PDF]

, 2009
Predicting protein function from structure remains an active area of interest, particularly for the structural genomics initiatives where a substantial number of structures are initially solved with little or no functional characterisation.
Dallman Timothy J., Nussinov, R., Oliver C. Redfern, Christine A. Orengo, Sillitoe, I., Dessailly Benoît H., Orengo, C.A., Benoît H Dessailly, Redfern, OC, Timothy J. Dallman, Oliver C Redfern, Benoît H. Dessailly, Dallman, TJ, Dessailly, B.H., Orengo Christine A., Ian Sillitoe, Timothy J Dallman, Sillitoe, I, Redfern Oliver C., Christine A Orengo, Dallman, T.J., Sillitoe Ian, Dessailly, BH, Redfern, O.C., Orengo, CA   +24 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Molecular basis for multidrug efflux by an anaerobic-associated RND transporter

Nature Communications
Bacteria can resist antibiotics and toxic substances within demanding ecological settings, such as low oxygen, extreme acid, and during nutrient starvation. MdtEF, a proton motive force-driven efflux pump from the resistance-nodulation-cell division (RND)
Ryan Lawrence, Mohd Athar, Muhammad R. Uddin, Christopher Adams, Joana S. Sousa, Oliver Durrant, Sophie Lellman, Lucy Sutton, C. William Keevil, Nisha Patel, Christine E. Prosser, David McMillan, Helen I. Zgurskaya, Attilio V. Vargiu, Zainab Ahdash, Eamonn Reading   +15 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Structure of the human marker of self 5-transmembrane receptor CD47

Nature Communications, 2021
CD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into the ...
Gustavo Fenalti, Nicolas Villanueva, Mark Griffith, Barbra Pagarigan, Sirish Kaushik Lakkaraju, Richard Y.-C. Huang, Nadia Ladygina, Alok Sharma, David Mikolon, Mahan Abbasian, Jeffrey Johnson, Haralambos Hadjivassiliou, Dan Zhu, Philip P. Chamberlain, Ho Cho, Kandasamy Hariharan   +15 more
doaj   +1 more source

Biotransformation of Lignin by an Artificial Heme Enzyme Designed in Myoglobin With a Covalently Linked Heme Group

Frontiers in Bioengineering and Biotechnology, 2021
The conversion of Kraft lignin in plant biomass into renewable chemicals, aiming at harvesting aromatic compounds, is a challenge process in biorefinery.
Wen-Jie Guo, Jia-Kun Xu, Jing-Jing Liu, Jia-Jia Lang, Shu-Qin Gao, Ge-Bo Wen, Ying-Wu Lin, Ying-Wu Lin   +7 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Why similar protein sequences encode similar three-dimensional structures? [PDF]

, 2010
Evolutionarily related proteins have similar sequences. Such similarity is called homology and can be described using substitution matrices such as Blosum 60.
Zielenkiewicz, Piotr, Kaczanowski, Szymon   +1 more
core   +1 more source

A Computational Model of the LGI1 Protein Suggests a Common Binding Site for ADAM Proteins [PDF]

, 2011
Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome.
Leonardi, Emanuela, Tosatto, Silvio C. E., Giorgia Busolin, Simonetta Andreazza, Busolin, Giorgia, Tosatto, Silvio C E, Emanuela Leonardi, Carlo Nobile, Silvio C E Tosatto, TOSATTO, SILVIO, Busolin Giorgia, Silvio C. E. Tosatto, Tosatto Silvio C. E., Vanin, Stefano, Vanin Stefano, NOBILE C, Langowski, Jörg, Stefano Vanin, Andreazza Simonetta, Andreazza, Simonetta, Nobile, Carlo, ANDREAZZA A, Leonardi Emanuela, Nobile Carlo, Tosatto Silvio C E   +24 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source