Results 21 to 30 of about 12,004,907 (291)
SDSL-ESR-based protein structure characterization [PDF]
, 2010 As proteins are key molecules in living cells, knowledge about their structure can provide important insights and applications in science, biotechnology, and medicine.
Hemminga, M.A. +6 more
core +1 more source
PON-SC – program for identifying steric clashes caused by amino acid substitutions
BMC Bioinformatics, 2017 Background Amino acid substitutions due to DNA nucleotide replacements are frequently disease-causing because of affecting functionally important sites.
Jelena Čalyševa, Mauno Vihinen
doaj +1 more source
Representativeness of variation benchmark datasets
BMC Bioinformatics, 2018 Background Benchmark datasets are essential for both method development and performance assessment. These datasets have numerous requirements, representativeness being one.
Gerard C. P. Schaafsma, Mauno Vihinen
doaj +1 more source
Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560
Nature Communications, 2022 Presenilin isoforms (PS1 and PS2) containing γ-secretase show contrasting sensitivity to MRK-560. Here, the authors determined cryo-EM structures of PS1/PS2-complexes treated with MRK-560 and identified key residues responsible for the isoform-dependent ...
Xuefei Guo +10 more
doaj +1 more source
Molecular basis for protein histidine N1-specific methylation of the “His-x-His” motifs by METTL9
Cell Insight, 2023 Histidine methylation serves as an intriguing strategy to introduce altered traits of target proteins, including metal ion chelation, histidine-based catalysis, molecular assembly, and translation regulation.
Wentao Zhao +6 more
doaj +1 more source
Cell-based assays to identify novel retinoprotective agents
MethodsX, 2020 Degeneration of the retina can lead ultimately to devastating irreversible vision loss, such as in inherited retinitis pigmentosa and age-related macular degeneration. Currently there is no cure to prevent retinal degeneration.
Jeanee Bullock +2 more
doaj +1 more source
Biomolecules, 2021 Glutathione transferases (GSTs) are the main detoxification enzymes in schistosomes. These parasitic enzymes tend to be upregulated during drug treatment, with Schistosoma haematobium being one of the species that mainly affect humans. There is a lack of
Neo Padi +5 more
doaj +1 more source
Studying protein-protein interactions using peptide arrays [PDF]
, 2010 Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T. +7 more
core +1 more source
A structural alignment kernel for protein structures [PDF]
Bioinformatics, 2007 AbstractMotivation: This work aims to develop computational methods to annotate protein structures in an automated fashion. We employ a support vector machine (SVM) classifier to map from a given class of structures to their corresponding structural (SCOP) or functional (Gene Ontology) annotation.
Jian Qiu +4 more
openaire +3 more sources
Functional properties of individual sub-domains of the fibrin(ogen) αC-domains
BBA Advances, 2023 Background: Fibrinogen is a large polyfunctional plasma protein consisting of a number of structural and functional domains. Among them, two αC-domains, each formed by the amino acid residues Аα392–610, are involved in fibrin polymerization, activation ...
Y.M. Stohnii +10 more
doaj +1 more source