Results 21 to 30 of about 3,619,143 (288)

Improvement of the affinity of an anti-rat P2X4 receptor antibody by introducing electrostatic interactions

Scientific Reports, 2022
We have recently developed a mouse monoclonal antibody (12–10H) binding to the head domain region in rat P2X4 receptor (rP2X4R, which is crucial for the pathogenesis of neuropathic pain) expressed on the cell with the highest binding affinity (K D = 20 ...
Chinatsu Shinozaki, Keita Kohno, Mitsunori Shiroishi, Daisuke Takahashi, Yu Yoshikawa, Yoshito Abe, Kenji Hamase, Makoto Nakakido, Kohei Tsumoto, Kazuhide Inoue, Makoto Tsuda, Tadashi Ueda   +11 more
doaj   +1 more source

Towards Reliable Automatic Protein Structure Alignment

, 2013
A variety of methods have been proposed for structure similarity calculation, which are called structure alignment or superposition. One major shortcoming in current structure alignment algorithms is in their inherent design, which is based on local ...
A. Caprara, A. Zemla, A.G. Murzin, A.S. Konagurthu, C.A. Rohl, C.B. Do, G. Lancia, H.M. Berman, I.N. Shindyalov, J. Shi, J. Xu, J.F. Gibrat, K. Mizuguchi, L. Kinch, L. Xie, M. Comin, M. Levitt, M. Moakher, M. Sadowski, N.M. Daniels, N.N. Alexandrov, S. Henikoff, S. Subbiah, S.B. Needleman, S.B. Pandit, S.R. Eddy, W. Pirovano, Y. Yang, Y. Ye, Y. Zhang, Y. Zhang, Y. Zhang   +31 more
core   +1 more source

The atomistic level structure for the activated human κ-opioid receptor bound to the full Gi protein and the MP1104 agonist [PDF]

, 2020
The kappa opioid receptor (κOR) is an important target for pain therapeutics to reduce depression and other harmful side effects of existing medications.
Goddard, William A., III, Kim, Soo-Kyung, Mafi, Amirhossein   +2 more
core   +1 more source

Of bits and bugs [PDF]

, 2010
Pur-α is a nucleic acid-binding protein involved in cell cycle control, transcription, and neuronal function. Initially no prediction of the three-dimensional structure of Pur-α was possible.
Graebsch, Almut, Kostrewa, Dirk, Niessing, Dierk, Roche, Stéphane, Söding, Johannes   +4 more
core   +1 more source

Identification of the Protein Glycation Sites in Human Myoglobin as Rapidly Induced by d-Ribose

Molecules, 2021
Protein glycation is an important protein post-translational modification and is one of the main pathogenesis of diabetic angiopathy. Other than glycated hemoglobin, the protein glycation of other globins such as myoglobin (Mb) is less studied.
Jing-Jing Liu, Yong You, Shu-Qin Gao, Shuai Tang, Lei Chen, Ge-Bo Wen, Ying-Wu Lin   +6 more
doaj   +1 more source

LoopIng: A template-based tool for predicting the structure of protein loops [PDF]

, 2015
MOTIVATION: Predicting the structure of protein loops is very challenging, mainly because they are not necessarily subject to strong evolutionary pressure.
ABDEL MESSIH, MARIO ALFY FAHMY, Lepore, Rosalba, Tramontano, Anna   +2 more
core   +1 more source

Subtype-Specific HIV-1 Protease and the Role of Hinge and Flap Dynamics in Drug Resistance: A Subtype C Narrative

Viruses
The HIV-1 aspartic protease is an effective target for the treatment of HIV/AIDS. Current therapy utilizes a selection of nine protease inhibitors (PIs) in combination with other classes of antiretroviral drugs.
Dean Sherry, Zaahida Sheik Ismail, Tshele Mokhantso, Yasien Sayed   +3 more
doaj   +1 more source

The spike glycoprotein of highly pathogenic human coronaviruses: structural insights for understanding infection, evolution and inhibition

FEBS Open Bio, 2022
Highly pathogenic human coronaviruses (CoV) including SARS‐CoV, MERS‐CoV and SARS‐CoV‐2 have emerged over the past two decades, resulting in infectious disease outbreaks that have greatly affected public health.
Shuyuan Qiao, Shuyuan Zhang, Jiwan Ge, Xinquan Wang   +3 more
doaj   +1 more source

Protein Structure Prediction: The Next Generation

, 2006
Over the last 10-15 years a general understanding of the chemical reaction of protein folding has emerged from statistical mechanics. The lessons learned from protein folding kinetics based on energy landscape ideas have benefited protein structure ...
Eastwood, Michael P., Hardin, Corey, Prentiss, Michael C., Wolynes, Peter G., Zong, Chenghong   +4 more
core   +1 more source

Degenerate cysteine patterns mediate two redox sensing mechanisms in the papillomavirus E7 oncoprotein

Redox Biology, 2017
Infection with oncogenic human papillomavirus induces deregulation of cellular redox homeostasis. Virus replication and papillomavirus-induced cell transformation require persistent expression of viral oncoproteins E7 and E6 that must retain their ...
Gabriela Camporeale, Juan R. Lorenzo, Maria G. Thomas, Edgardo Salvatierra, Silvia S. Borkosky, Marikena G. Risso, Ignacio E. Sánchez, Gonzalo de Prat Gay, Leonardo G. Alonso   +8 more
doaj   +1 more source