Results 31 to 40 of about 3,619,143 (288)

Structure of the human marker of self 5-transmembrane receptor CD47

Nature Communications, 2021
CD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into the ...
Gustavo Fenalti, Nicolas Villanueva, Mark Griffith, Barbra Pagarigan, Sirish Kaushik Lakkaraju, Richard Y.-C. Huang, Nadia Ladygina, Alok Sharma, David Mikolon, Mahan Abbasian, Jeffrey Johnson, Haralambos Hadjivassiliou, Dan Zhu, Philip P. Chamberlain, Ho Cho, Kandasamy Hariharan   +15 more
doaj   +1 more source

On the optimal contact potential of proteins

, 2007
We analytically derive the lower bound of the total conformational energy of a protein structure by assuming that the total conformational energy is well approximated by the sum of sequence-dependent pairwise contact energies.
Akira R. Kinjo, Anfinsen, Bastolla, Cao, Cao, Cheng, Chikenji, Fleming, Graña, Gō, Hao, Horn, Horn, Ishida, Kabakçiogˇlu, Kinjo, Kinjo, Kinjo, Kinjo, Li, Mitsutake, Miyazawa, Miyazawa, Munson, Porto, Sanzo Miyazawa, Takada, Taketomi, Vendruscolo, Vendruscolo, Vendruscolo, Vullo, Yuan   +32 more
core   +1 more source

Nuclear VPS35 attenuates NHEJ repair by sequestering Ku protein

Molecular Medicine
Vacuolar protein sorting-associated protein 35 (VPS35), a pivotal constituent of the retromer complex, mediates the retrograde trafficking of endosomal cargoes in the cytoplasm.
Luping Zhang, Yonghong Nie, Tuo Tang, Yanji Lu, Wenlong Li, Xian Hong, Qiang Li, Aixue Zheng, Yongpei Li, Jianwen Zhou, Li Fan, Tao Wang, Zhihui Deng   +12 more
doaj   +1 more source

RuvC uses dynamic probing of the Holliday junction to achieve sequence specificity and efficient resolution

Nature Communications, 2019
Holliday junctions (HJs) are four-way DNA structures that occur in DNA repair by homologous recombination which are removed by nucleases such as RuvC. Here the authors provide structural and biochemical details on the steps required for the completion of
Karolina Maria Górecka, Miroslav Krepl, Aleksandra Szlachcic, Jarosław Poznański, Jiří Šponer, Marcin Nowotny   +5 more
doaj   +1 more source

Biotransformation of Lignin by an Artificial Heme Enzyme Designed in Myoglobin With a Covalently Linked Heme Group

Frontiers in Bioengineering and Biotechnology, 2021
The conversion of Kraft lignin in plant biomass into renewable chemicals, aiming at harvesting aromatic compounds, is a challenge process in biorefinery.
Wen-Jie Guo, Jia-Kun Xu, Jing-Jing Liu, Jia-Jia Lang, Shu-Qin Gao, Ge-Bo Wen, Ying-Wu Lin, Ying-Wu Lin   +7 more
doaj   +1 more source

Introduction to Protein Structure Prediction [PDF]

, 2017
This chapter gives a graceful introduction to problem of protein three- dimensional structure prediction, and focuses on how to make structural sense out of a single input sequence with unknown structure, the 'query' or 'target' sequence.
Abeln, Sanne, Feenstra, K. Anton, Heringa, Jaap   +2 more
core   +1 more source

Reconstruction of protein structures from a vectorial representation

, 2004
We show that the contact map of the native structure of globular proteins can be reconstructed starting from the sole knowledge of the contact map's principal eigenvector, and present an exact algorithm for this purpose.
B. Bollobas, H. Eduardo Roman, I. Koh, L. Holm, M. Vendruscolo, Markus Porto, Michele Vendruscolo, N. Kannan, P. Fariselli, S. Lifson, Ugo Bastolla   +10 more
core   +1 more source

Understanding structural variability in proteins using protein structural networks

Current Research in Structural Biology, 2022
Proteins perform their function by accessing a suitable conformer from the ensemble of available conformations. The conformational diversity of a chosen protein structure can be obtained by experimental methods under different conditions. A key issue is the accurate comparison of different conformations.
Vasam Manjveekar Prabantu, Vasundhara Gadiyaram, Saraswathi Vishveshwara, Narayanaswamy Srinivasan   +3 more
openaire   +3 more sources

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Water Dynamics at Protein Interfaces: Ultrafast Optical Kerr Effect Study [PDF]

, 2012
The behavior of water molecules surrounding a protein can have an important bearing on its structure and function. Consequently, a great deal of attention has been focused on changes in the relaxation dynamics of water when it is located at the protein ...
Bizzarri A. R., Bizzarri A. R., Born B., Bucaro J. A., Castner E. W., Chang Y. J., Colaianni S. E. M., de Morais L. C., Eaves J. D., Ebbinghaus S., Eriksson K. O., Feig M., Giraud G., Halle B., Halle B., Hamm P., Heisler I. A., Heisler I. A., Heugen U., Heyden M., Hunt N. T., Hunt N. T., Hunt N. T., Hunt N. T., Ismael A. Heisler, James T. L., Kamila Mazur, Kato A., Kuntz I. D., Laage D., Laage D., Lang E. W., Lee B., Lee B., Lerbret A., Levy Y., Lotshaw W. T., Mahn A., Malardier-Jugroot C., Marchi M., Marti J., Mazur K., Mazur K., Mazzacurati V., McMorrow D., Mizoguchi K., Modig K., Moon Y. U., Murphy W. F., Nakayama T., Nandi N., Nielsen O. F., Ohmine I., Ohmine I., Paolantoni M., Perticaroli S., Potma E. O., Qvist J., Qvist J., Rejoumichel A., Rezus Y. L. A., Rupley J. A., Russo D., Shenogina N., Shirota H., Shirota H., Smith N. A., Stephen R. Meech, Stirnemann G., Torre R., Urabe H., Winkler K., Xu J., Yokoyama K., Zhong Q.   +74 more
core   +1 more source