Results 31 to 40 of about 12,004,907 (291)

CHAPTER 1.1. Disulfide Bonds in Protein Folding and Stability [PDF]

open access: yes, 2018
Disulfide bonds are unique among post-translational modifications, as they add covalent crosslinks to the polypeptide chain. Accordingly, they can exert pronounced effects on protein folding and stability. This is of particular importance for secreted or
Sub Cellular Protein Chemistry   +7 more
core   +1 more source

Structural Proteins of Reoviruses [PDF]

open access: yesJournal of Virology, 1968
Polyacrylamide gel electrophoresis of the solubilized proteins from the three serotypes of reovirus revealed that each contained three major and four minor components. Subviral particles were prepared by brief treatment of complete virions with urea.
P C, Loh, A J, Shatkin
openaire   +2 more sources

DNA Variations between Medicago truncatula Symbiotic Mutant Line and Native Variant Using Fluorescence-Based AFLP Marker

open access: yesHighlights in BioScience, 2020
Genetic mutagenesis is a very efficient tool in studying genes function. Because of the great benefits of legumes as human food and animal feed worldwide, we used a model plant Medicago truncatula for identification gene function related to nitrogen ...
Asmaa Hamdy Hassan   +2 more
doaj   +1 more source

Non-Contiguous Protein Recombination [PDF]

open access: yes, 2013
Swapping sequence elements among related proteins can produce chimeric proteins with novel behaviors and improved properties such as enhanced stability. Although homologous mutations are much more conservative than random mutations, chimeras of distantly-
Smith, Matthew Alexander
core   +1 more source

Prediction of Protein Function Using Statistically Significant Sub-Structure Discovery [PDF]

open access: yes, 2007
Proteins perform a vast number of functional roles. The number of protein structures available for analysis continues to grow and, with the development of methods to predict protein structure directly from genetic sequence without imaging technology, the
Lucas, Craig
core   +7 more sources

Protein structure prediction [PDF]

open access: yesInternational Journal of Modern Physics B, 2018
Predicting 3D structure of protein from its amino acid sequence is one of the most important unsolved problems in biophysics and computational biology. This paper attempts to give a comprehensive introduction of the most recent effort and progress on protein structure prediction.
Haiyou, Deng, Ya, Jia, Yang, Zhang
openaire   +2 more sources

Improvement of the affinity of an anti-rat P2X4 receptor antibody by introducing electrostatic interactions

open access: yesScientific Reports, 2022
We have recently developed a mouse monoclonal antibody (12–10H) binding to the head domain region in rat P2X4 receptor (rP2X4R, which is crucial for the pathogenesis of neuropathic pain) expressed on the cell with the highest binding affinity (K D = 20 ...
Chinatsu Shinozaki   +11 more
doaj   +1 more source

A Novel Method for Accurate One-dimensional Protein Structure Prediction Based on Fragment Matching

open access: yes, 2010
Motivation: The precise prediction of one-dimensional (1D) protein structure as represented by the protein secondary structure and 1D string of discrete state of dihedral angles (i.e.
Hovmöller, Sven,   +2 more
core   +1 more source

Subtype-Specific HIV-1 Protease and the Role of Hinge and Flap Dynamics in Drug Resistance: A Subtype C Narrative

open access: yesViruses
The HIV-1 aspartic protease is an effective target for the treatment of HIV/AIDS. Current therapy utilizes a selection of nine protease inhibitors (PIs) in combination with other classes of antiretroviral drugs.
Dean Sherry   +3 more
doaj   +1 more source

Protein mysterious structure and numerous functions department [PDF]

open access: yesThe Ukrainian Biochemical Journal
This overview is dedicated to the history of the Department of Protein Structure and Function at the Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine. It outlines the department’s main scientific objectives and highlights
V. O. Chernyshenko, V. I. Gryshchuk
doaj   +1 more source

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