Results 51 to 60 of about 3,619,143 (288)
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Nature Communications, 2023 Molecular interplay between host epigenetic factors and viral proteins constitutes an intriguing mechanism for sustaining hepatitis B virus (HBV) life cycle and its chronic infection.
Wei Liu +12 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Does a Simple Lattice Protein Exhibit Self-Organized Criticality? [PDF]
, 2015 There are many unanswered questions when it comes to protein folding. These questions are interesting because the tertiary structure of proteins determines its functionality in living organisms.
Bajracharya, Arun +2 more
core +1 more source
Protein thermodynamic structure [PDF]
IUBMB Life, 2009 AbstractProtein research is generally recognized as experimental science and knowledge of protein science is not constructed axiomatically. In this article, we show that much of our present knowledge of protein science is explainable by principles of protein thermodynamic structure theory. A deductive system for protein knowledge has been developed and
openaire +2 more sources
The Protein Structure Initiative Structural Genomics Knowledgebase [PDF]
The FASEB Journal, 2009 The Protein Structure Initiative (PSI) has produced more than 3300 protein structures in a high throughput manner. In order to achieve this, new technologies for all aspects of the structure determination and analysis pipeline have been developed.
Berman, H. M. +16 more
openaire +5 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
De novo design of protein minibinder agonists of TLR3
Nature CommunicationsToll-like Receptor 3 (TLR3) is a pattern recognition receptor that initiates antiviral immune responses upon binding double-stranded RNA (dsRNA). Several nucleic acid-based TLR3 agonists have been explored clinically as vaccine adjuvants in cancer and ...
Chloe S. Adams +9 more
doaj +1 more source
Wnt signaling polarizes cortical actin polymerization to increase daughter cell asymmetry
Cell Discovery, 2022 Asymmetric positioning of the mitotic spindle contributes to the generation of two daughter cells with distinct sizes and fates. Here, we investigated an asymmetric division in the Caenorhabditis elegans Q neuroblast lineage.
Yongping Chai +7 more
doaj +1 more source
Analysis of Three-Dimensional Protein Images [PDF]
, 1997 A fundamental goal of research in molecular biology is to understand protein structure. Protein crystallography is currently the most successful method for determining the three-dimensional (3D) conformation of a protein, yet it remains labor intensive ...
Baxter, K. +4 more
core +2 more sources