FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
3 = 1 + 2: how the divide conquered de novo protein structure prediction and what is next? [PDF]
Natl Sci Rev, 2023 Zhou Y, Litfin T, Zhan J.
europepmc +1 more source
FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source
Emerging frontiers in protein structure prediction following the AlphaFold revolution. [PDF]
J R Soc InterfaceRennie ML, Oliver MR.
europepmc +1 more source
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Adaptive gradient scaling: integrating Adam and landscape modification for protein structure prediction. [PDF]
BMC BioinformaticsKapitan V, Choi M.
europepmc +1 more source
Multi-domain and complex protein structure prediction using inter-domain interactions from deep learning. [PDF]
Commun Biol, 2023 Xia Y, Zhao K, Liu D, Zhou X, Zhang G.
europepmc +1 more source
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
Protein structure prediction via deep learning: an in-depth review. [PDF]
Front PharmacolMeng Y +7 more
europepmc +1 more source
Protein structure prediction has reached the single-structure frontier. [PDF]
Nat Methods, 2023 Lane TJ.
europepmc +1 more source