Results 161 to 170 of about 410,461 (311)
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Critical assessment of methods of protein structure prediction (CASP)-Round XV. [PDF]
Proteins, 2023 Kryshtafovych A +4 more
europepmc +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
The transformative power of transformers in protein structure prediction. [PDF]
Proc Natl Acad Sci U S A, 2023 Moussad B, Roche R, Bhattacharya D.
europepmc +1 more source
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
Protein folding in silico : protein folding versus protein structure prediction /
, 2012 Protein folding is a process by which a protein structure assumes its functional shape of conformation, and has been the subject of research since the publication of the first software tool for protein structure prediction.
Roterman-Konieczna, Irena,editor.
core
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Protein secondary structure prediction by artificial neural networks
, 2010 碩士蛋白質的組成控制著它的功能，而人體裡面有數百甚至數千個蛋白質的存在，因此我們會想要去知道蛋白質個別的功用及它們之間彼此是如何互動的，而這個領域被稱作蛋白質體學，它的目的主要是在調查在生物裡面的蛋白質的功能為何。 蛋白質的功能是決定於它的架構，目前X光結晶繞射照影(X-ray Crystallography) 與核磁共振(Nuclear Magnetic Resonance)(NMR)都能夠視覺化蛋白質的三維架構。然而它們是耗費時間且昂貴的，而所耗費的時間長達數週到數個月，另外也有解析上的問題 ...
張建蒼; Chang, Jian-tsang
core
Peptide binder design with inverse folding and protein structure prediction. [PDF]
Commun Chem, 2023 Bryant P, Elofsson A.
europepmc +1 more source
Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source