Results 161 to 170 of about 394,231 (262)

Protein structure prediction on the Web [PDF]

Nature Biotechnology, 1997
openaire   +2 more sources

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Advancements in one-dimensional protein structure prediction using machine learning and deep learning. [PDF]

Comput Struct Biotechnol J
Alanazi W, Meng D, Pollastri G.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

LightRoseTTA: High-Efficient and Accurate Protein Structure Prediction Using a Light-Weight Deep Graph Model. [PDF]

Adv Sci (Weinh)
Wang X, Zhang T, Liu G, Cui Z, Zeng Z, Long C, Zheng W, Yang J.   +7 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Proteins with alternative folds reveal blind spots in AlphaFold-based protein structure prediction. [PDF]

Curr Opin Struct Biol
Chakravarty D, Lee M, Porter LL.
europepmc   +1 more source

Protein Structure Prediction and Structural Annotation of Proteomes [PDF]

, 2013
Roche, Daniel Barry, Buenavista, Maria Teresa, McGuffin, Liam James   +2 more
openaire   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

AI-Driven Deep Learning Techniques in Protein Structure Prediction. [PDF]

Int J Mol Sci
Chen L, Li Q, Nasif KFA, Xie Y, Deng B, Niu S, Pouriyeh S, Dai Z, Chen J, Xie CY.   +9 more
europepmc   +1 more source