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Predicting Protein Structures Accurately
Science, 2004In their Research Article “Design of a novel globular protein fold with atomic-level accuracy,” B. Kuhlman et al. describe an extremely successful attempt to design a new protein (Top7) that folds to a predefined structure (21 Nov, p. [1364][1]).
Marcin, von Grotthuss +3 more
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Protein Structure Prediction and Structural Genomics
Science, 2001Genome sequencing projects are producing linear amino acid sequences, but full understanding of the biological role of these proteins will require knowledge of their structure and function. Although experimental structure determination methods are providing high-resolution structure information about a subset of the proteins, computational structure ...
D, Baker, A, Sali
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Prediction of Protein Structure
2004Publisher Summary This chapter describes the extraction of structural information from protein sequence. The deduced sequences of proteins provide invaluable insights into the functions of those proteins and the evolution of the organisms producing those proteins.
Robert H, Kretsinger +2 more
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Protein Secondary Structure Prediction
2009While the prediction of a native protein structure from sequence continues to remain a challenging problem, over the past decades computational methods have become quite successful in exploiting the mechanisms behind secondary structure formation. The great effort expended in this area has resulted in the development of a vast number of secondary ...
Pirovano, W.A., Heringa, J.
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2006
Abstract Over the past decade, the success of genome sequence efforts has brought about a paradigm shift in biology [1]. There is increasing emphasis on the large-scale, high-throughput examination of all genes and gene products of an organism, with the aim of assigning their functions [2]. Of course, biological function is multifaceted,
Jeffrey Skolnick, Yang Zhang
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Abstract Over the past decade, the success of genome sequence efforts has brought about a paradigm shift in biology [1]. There is increasing emphasis on the large-scale, high-throughput examination of all genes and gene products of an organism, with the aim of assigning their functions [2]. Of course, biological function is multifaceted,
Jeffrey Skolnick, Yang Zhang
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2014
1. Protein Structure Modeling with MODELLER Benjamin Webb, Andrej Sali 2. RaptorX Server: A Resource for Template-based Protein Structure Modeling Morten Kallberg, Gohar Margaryan, Sheng Wang, Jianzhu Ma and Jinbo Xu 3. The MULTICOM Protein Tertiary Structure Prediction System Jilong Li, Debswapna Bhattacharya, Renzhi Cao, Badri Adhikari, Xin Deng ...
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1. Protein Structure Modeling with MODELLER Benjamin Webb, Andrej Sali 2. RaptorX Server: A Resource for Template-based Protein Structure Modeling Morten Kallberg, Gohar Margaryan, Sheng Wang, Jianzhu Ma and Jinbo Xu 3. The MULTICOM Protein Tertiary Structure Prediction System Jilong Li, Debswapna Bhattacharya, Renzhi Cao, Badri Adhikari, Xin Deng ...
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2010
The molecular basis of life rests on the activity of large biomolecules, mostly nucleic acids(DNA and RNA), carbohydrates, lipids, and proteins. While each of these molecules has itsrole, there is something special about proteins, as they are the lead performers of cellular functions.This was dramatized by Jacques Monod, who stated that “C’est a ce ...
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The molecular basis of life rests on the activity of large biomolecules, mostly nucleic acids(DNA and RNA), carbohydrates, lipids, and proteins. While each of these molecules has itsrole, there is something special about proteins, as they are the lead performers of cellular functions.This was dramatized by Jacques Monod, who stated that “C’est a ce ...
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Protein structure prediction and design
1998Proteins have a unique native conformation, which can be proven in many instances to be determined by the amino acid sequence alone. The folding problem, that is the understanding of how the amino acid sequence directs folding, is still unsolved, despite more than 30 years of effort. However, many new methods have appeared in the past few years.
Morea V, Leplae R, Tramontano, A
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2017
This chapter concentrates on protein structure prediction programs. It provides strong foundational knowledge of protein structures and the Protein Data Bank. The chapter reviews how secondary and tertiary structures of proteins are experimentally determined and how bioinformatics programs can be used to visualize these structures.
Jamil Momand +3 more
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This chapter concentrates on protein structure prediction programs. It provides strong foundational knowledge of protein structures and the Protein Data Bank. The chapter reviews how secondary and tertiary structures of proteins are experimentally determined and how bioinformatics programs can be used to visualize these structures.
Jamil Momand +3 more
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Predicting protein three-dimensional structure
Current Opinion in Biotechnology, 1999The current state of the art in modeling protein structure has been assessed, based on the results of the CASP (Critical Assessment of protein Structure Prediction) experiments. In comparative modeling, improvements have been made in sequence alignment, sidechain orientation and loop building.
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