Results 51 to 60 of about 410,461 (311)

Naive Prediction of Protein Backbone Phi and Psi Dihedral Angles Using Deep Learning

Molecules, 2023
Protein structure prediction represents a significant challenge in the field of bioinformatics, with the prediction of protein structures using backbone dihedral angles recently achieving significant progress due to the rise of deep neural network ...
Matic Broz, Marko Jukič, Urban Bren
doaj   +1 more source

A coarse-grained Langevin molecular dynamics approach to de novo protein structure prediction [PDF]

, 2008
De novo prediction of protein structures, the prediction of structures from amino acid sequences which are not similar to those of hitherto resolved structures, has been one of the major challenges in molecular biophysics. In this paper, we develop a new
Sasaki, Takeshi N., Cetin, Hikmet, Sasai, Masaki   +2 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Bayesian Markov Random Rield Analysis for Protein Function Prediction Based on Network Data

, 2010
Inference of protein functions is one of the most important aims of modern biology. To fully exploit the large volumes of genomic data typically produced in modern-day genomic experiments, automated computational methods for protein function prediction ...
ter Braak, C.J.F., Yiannis A I Kourmpetis, Cajo J F ter Braak, Kourmpetis, Y.I.A., Roeland C H J van Ham, Ham, R.C.H.J., van, Aalt D J van Dijk, van Dijk, A.D.J., Bink, M.C.A.M., van Dijk Aalt D. J., Kourmpetis Yiannis A. I., van Ham Roeland C. H. J., Dijk, A.D.J., van, Bink Marco C. A. M., Braak, C.J.F., ter, Marco C A M Bink, van Ham, R.C.H.J., ter Braak Cajo J. F.   +17 more
core   +1 more source

ClusterEmbed: Lightweight Protein Structure Prediction on PCs [PDF]

BIO Web of Conferences
Biological sequence design seeks to generate novel sequences, such as proteins, with optimized functional properties, a task complicated by vast combinatorial spaces and complex sequence-function relationships.
Yuan Chuxin
doaj   +1 more source

Performance Analysis of Deep Learning Methods for Protein Contact Prediction in CASP13

CLEI Electronic Journal, 2021
Protein structure prediction is one of the most important problems in Computational Biology; and consists of determining the 3D structure of a protein given its amino acid sequence.
Romina Valdez, Khevin Roig, Diego P. Pinto-Roa, Jose Colbes   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The MULTICOM toolbox for protein structure prediction

BMC Bioinformatics, 2012
Background As genome sequencing is becoming routine in biomedical research, the total number of protein sequences is increasing exponentially, recently reaching over 108 million. However, only a tiny portion of these proteins (i.e.
Cheng Jianlin, Li Jilong, Wang Zheng, Eickholt Jesse, Deng Xin   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source