Results 81 to 90 of about 1,677,396 (366)

The MULTICOM toolbox for protein structure prediction

BMC Bioinformatics, 2012
Background As genome sequencing is becoming routine in biomedical research, the total number of protein sequences is increasing exponentially, recently reaching over 108 million. However, only a tiny portion of these proteins (i.e.
Cheng Jianlin, Li Jilong, Wang Zheng, Eickholt Jesse, Deng Xin   +4 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Domain discovery method for topological profile searches in protein structures [PDF]

, 2004
We describe a method for automated domain discovery for topological profile searches in protein structures. The method is used in a system TOPStructure for fast prediction of CATH classification for protein structures (given as PDB files).
Gilbert, D, Torrance, G, Viksna, J
core   +1 more source

On the optimal contact potential of proteins

, 2007
We analytically derive the lower bound of the total conformational energy of a protein structure by assuming that the total conformational energy is well approximated by the sum of sequence-dependent pairwise contact energies.
Akira R. Kinjo, Anfinsen, Bastolla, Cao, Cao, Cheng, Chikenji, Fleming, Graña, Gō, Hao, Horn, Horn, Ishida, Kabakçiogˇlu, Kinjo, Kinjo, Kinjo, Kinjo, Li, Mitsutake, Miyazawa, Miyazawa, Munson, Porto, Sanzo Miyazawa, Takada, Taketomi, Vendruscolo, Vendruscolo, Vendruscolo, Vullo, Yuan   +32 more
core   +1 more source

Flexible protein folding by ant colony optimization [PDF]

, 2008
Protein structure prediction is one of the most challenging topics in bioinformatics. As the protein structure is found to be closely related to its functions, predicting the folding structure of a protein to judge its functions is meaningful to the ...
Hu, X., Li, Y., Zhang, J.
core   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

: Protein Long Local Structure Prediction [PDF]

, 2009
International audienceA relevant and accurate description of three-dimensional (3D) protein structures can be achieved by characterizing recurrent local structures.
Altschul, Baeten, Benros, Benros, Blundell, Boeckmann, Bowie, Bystroff, Bystroff, de Bakker, de Brevern, de Brevern, de Brevern, de Brevern, de Brevern, de Brevern, de Brevern, Dong, Doppelt, Dudev, Eddy, Etchebest, Etchebest, Fawcett, Fiser, Fitzkee, Fourrier, Hastie, Hazout, Ihaka, Jauch, Joachims, Jones, Karchin, Kohonen, Kuang, Kuang, Lewis, Lin, Mittelman, Murzin, Noble, Noguchi, Offmann, Pei, Rangwala, Rohl, Rooman, Sander, Sawada, Song, Soto, Tyagi, Tyagi, Tyagi, Ward, Xiang, Yang, Zhang, Zhou, Zhu   +60 more
core   +4 more sources

Integration of Multi-Feature Fusion and PLS-DA in Protein Secondary Structure Prediction

MATEC Web of Conferences, 2016
Protein structure prediction has become one of the central problems in the field of modern computational biology. Protein secondary structure prediction is the basis of the spatial structure prediction of proteins.
Huang Guangzao, Tang Meishuang, Guan Jinting, Zhou Sun, Zhu Wenbing, Ji Guoli   +5 more
doaj   +1 more source

ClusterEmbed: Lightweight Protein Structure Prediction on PCs [PDF]

BIO Web of Conferences
Biological sequence design seeks to generate novel sequences, such as proteins, with optimized functional properties, a task complicated by vast combinatorial spaces and complex sequence-function relationships.
Yuan Chuxin
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source