Results 201 to 210 of about 101,248 (253)

Make a short story long: About novel long-non coding RNA regulator of CFTR gene expression. [PDF]

Mol Ther Nucleic Acids
Szczepankiewicz A.
europepmc   +1 more source

FBP1‐Mediated Compartmentalization of Glycolytic Enzyme Complexes Suppresses PKM2 Function to Ameliorate MASLD Progression

Advanced Science, EarlyView.
In normal hepatocytes, FBP1 forms compartmentalized complexes with PKM2, ENO1, and LDHA independent of its catalytic activity, inhibiting PKM2 activity and restricting excessive glycolysis. During MASLD progression, FBP1 downregulation markedly reduces the abundance of these complexes and releases the “hijacked” glycolytic enzymes, leading to PKM2 ...
Busong Wang, Yiping Tang, Na Li, Xuening Dai, Jing Wu, Bin Xue, Yuxin Chen, Jingzi Zhang, Lingdong Kong, Chaojun Li, Lei Fang   +10 more
wiley   +1 more source

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

Cell painting and thermal proteome profiling for inference of drug targets and mechanism of action. [PDF]

Mol Syst Biol
Johansson C, Johansson M, Kasi PB, Larsson M, Jakobsson PJ, Göransson U, Carreras Puigvert J, Spjuth O, Jansson ET.   +8 more
europepmc   +1 more source

Epigenetic Silencing of CYYR1 Promotes Lung Adenocarcinoma Progression Through TRIM21‐Dependent Regulation of HMMR Stability

Advanced Science, EarlyView.
CYYR1 as an epigenetically dysregulated tumor‐suppressive factor that influences oncoprotein stability through TRIM21‐dependent HMMR regulation and reveals a potential therapeutic vulnerability in CYYR1‐deficient LUAD. The graphical illustration was created using FigDraw (www.figdraw.com).
Fengsheng Dai, Jingyi Tang, Huan Rong, Yu Wang, Xiangyi Zhou, Can Xu, Jianhua Wang, Lili Li, Yue Wu, Fei Deng, Dan Yang, Xiao Yang, Renyan Li, Yongzhong Wu, Dongxi Xiang, Tingxiu Xiang   +15 more
wiley   +1 more source

TRK immunohistochemistry in pediatric rhabdomyosarcomas: diagnostic and prognostic utility and limitations. [PDF]

Pathol Oncol Res
Lajti R, Dezső K, Sápi Z, Papp G, Mohás A, Bukovszky B, Szabó S, Felkai L, Csóka M.   +8 more
europepmc   +1 more source

Location-biased β-arrestin conformations direct GPCR signaling. [PDF]

Sci Signal
Pham U, Chundi A, Stępniewski TM, Darbha S, Eiger DS, Gazula S, Gardner J, Hicks C, Selent J, Rajagopal S.   +9 more
europepmc   +1 more source

DUOX-Generated Intestinal ROS Restrict Spore Adhesion and Invasion of <i>Nosema bombycis</i> in Silkworm <i>Bombyx mori</i>. [PDF]

Biology (Basel)
Wang H, Huang T, Wang P, Hai Q, Ma R, Yu M, Dang X, Xu J, Li C, Pan G, Ma Z, Zhou Z.   +11 more
europepmc   +1 more source

Organelle proteomics reveals novel metabolic vulnerabilities in FLT3-ITD cells. [PDF]

Leukemia
Bica V, Pacilè AF, Boettcher M, Marano V, Marabitti V, Nazio F, Cortese M, Fischer T, Perfetto L, Mougiakakos D, Massacci G, Sacco F.   +11 more
europepmc   +1 more source