Results 31 to 40 of about 1,344,747 (350)

Absolute Protein Amounts and Relative Abundance of Volume-regulated Anion Channel (VRAC) LRRC8 Subunits in Cells and Tissues Revealed by Quantitative Immunoblotting [PDF]

, 2019
The volume-regulated anion channel (VRAC) plays an important role in osmotic cell volume regulation. In addition, it is involved in various physiological processes such as insulin secretion, glia-neuron communication and purinergic signaling.
Kopp, Anja, Pervaiz, Sumaira, Stauber, Tobias, von Kleist, Lisa   +3 more
core   +1 more source

Cholesterol down-regulates BK channels stably expressed in HEK 293 cells. [PDF]

PLoS ONE, 2013
Cholesterol is one of the major lipid components of the plasma membrane in mammalian cells and is involved in the regulation of a number of ion channels.
Wei Wu, Yan Wang, Xiu-Ling Deng, Hai-Ying Sun, Gui-Rong Li   +4 more
doaj   +1 more source

Primary Structure and Conformation of a Tetrodotoxin-Binding Protein in the Hemolymph of Non-Toxic Shore Crab Hemigrapsus sanguineus

Journal of Marine Science and Engineering, 2023
Tetrodotoxin (TTX)-binding proteins are present in toxic TTX-bearing animals, such as pufferfish and gastropods. These may prevent autotoxicity. However, TTX-binding proteins are also found in the nontoxic marine shore crab, Hemigrapsus sanguineus. Here,
Yuji Nagashima, Kenta Fujimoto, Masahiko Okai, Yoichiro Kitani, Aya Yoshinaga-Kiriake, Shoichiro Ishizaki   +5 more
doaj   +1 more source

Molecular architecture of Gαo and the structural basis for RGS16-mediated deactivation [PDF]

, 2008
Heterotrimeric G proteins relay extracellular cues from heptahelical transmembrane receptors to downstream effector molecules. Composed of an α subunit with intrinsic GTPase activity and a βγ heterodimer, the trimeric complex dissociates upon receptor ...
Berman, C.-K. Chen, Chan, Chen, Chen, Chen, Coleman, De Vries, Grafstein-Dunn, He, Heximer, K. C. Slep, Kimple, Koelle, Kozasa, Kozasa, Kudlacek, Lodowski, M. A. Kercher, M. I. Simon, McIntire, Neubig, Noel, P. B. Sigler, Slep, Snow, Sondek, Sunahara, T. Wieland, Tesmer, Tesmer, Valenzuela, Wang, Wilkie, Willars   +34 more
core   +4 more sources

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources

A Subunit Vaccine Based on E2 Protein of Atypical Porcine Pestivirus Induces Th2-type Immune Response in Mice

Viruses, 2018
An atypical porcine pestivirus (APPV) causing congenital tremor type A-II in piglets was identified in China in 2016. An increased number of cases of APPV have been reported in various countries all over the world since 2015.
Huawei Zhang, Wei Wen, Genxi Hao, Huanchun Chen, Ping Qian, Xiangmin Li   +5 more
doaj   +1 more source

Protein Kinase A Regulatory Subunits in Colon Cancer

Neoplasia: An International Journal for Oncology Research, 1999
The protein kinase A (PKA) is classified as type I or II depending on the association of the catalytic subunit with either the RI or RII regulatory subunits.
Chris C. Carlson, Stacy L. Smithers, Karen A. Yeh, Laura L. Burnham, Daniel T. Dransfield   +4 more
doaj   +1 more source

The yeast F1-ATPase beta subunit precursor contains functionally redundant mitochondrial protein import information [PDF]

, 1987
The NH2 terminus of the yeast F1-ATPase beta subunit precursor directs the import of this protein into mitochondria. To define the functionally important components of this import signal, oligonucleotide-directed mutagenesis was used to introduce a ...
Bedwell, David M., Emr, Scott D., Klionsky, Daniel J.   +2 more
core   +1 more source

Bioenergetic Consequences of FLAG Tag Addition to the C-Terminus of Subunit 8 of Yeast Saccharomyces cerevisiae Mitochondrial ATP Synthase

Hayati Journal of Biosciences, 2010
The yeast mitochondrial F1F0-ATP synthase is a multisubunit complex that contains at least 17 different subunits. Subunit 8 of yeast mitochondrial ATP synthase is a hydrophobic protein of 48 amino acids encoded by the mitochondrial ATP8 gene.
I MADE ARTIKA
doaj   +3 more sources

Generation of active protein phosphatase 2A is coupled to holoenzyme assembly. [PDF]

PLoS Biology, 2007
Protein phosphatase 2A (PP2A) is a prime example of the multisubunit architecture of protein serine/threonine phosphatases. Until substrate-specific PP2A holoenzymes assemble, a constitutively active, but nonspecific, catalytic C subunit would constitute
Hans Hombauer, David Weismann, Ingrid Mudrak, Claudia Stanzel, Thomas Fellner, Daniel H Lackner, Egon Ogris   +6 more
doaj   +1 more source