Results 251 to 260 of about 450,139 (318)

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Tracking single-molecule ferritin reassembly and disassembly using polymer-coated nanopores.

Nanoscale
Assadipapari M, Soleimanian A, Adam M, Li J, Yousefi A, Zargarbashi S, Xu L, Wills MFK, Kara H, Santana Vega M, Clark AW, Hudson AJ, Huang JA, Rahmani M, Ying C.   +14 more
europepmc   +1 more source

Assembly and lipid-gating of LRRC8A:D volume-regulated anion channels. [PDF]

Nat Commun
Lurie A, Stephens CA, Kern DM, Henn KM, Latorraca NR, Brohawn SG.   +5 more
europepmc   +1 more source

Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier

Advanced Science, EarlyView.
SETD2 ablation causes dysregulation and recruitment defects of ribosome biogenesis factors, resulting in translational disorders of barrier maintenance genes, thereby compromising the intestinal barrier. These findings unveil a previously unappreciated role of ribosome biogenesis and translational regulation in preserving the intestinal epithelial ...
Hanyu Rao, Aiting Wang, Yue Xu, Wenxin Feng, Chunxiao Ma, Ziyi Wang, Wei Zhang, Wenqiong Su, Xiuying Xiao, Wei‐Qiang Gao, Xianting Ding, Li Li   +11 more
wiley   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

The Conserved GTPase LepA May Contribute to the Final Proper Stabilization of the 3' Domain of the 30S Subunit During Ribosome Assembly. [PDF]

Int J Mol Sci
Kravchenko O, Maksimova E, Baymukhametov T, Eliseeva I, Stolboushkina E.   +4 more
europepmc   +1 more source

Conservation of human NMDA receptor subunits and disease variants in zebrafish. [PDF]

BMC Genomics
Nebet ER, Aprea C, Zoodsma JD, Raab WJ, Sirotkin HI, Wollmuth LP.   +5 more
europepmc   +1 more source

Molecular Physiology of the Neuronal Synapse. [PDF]

Curr Issues Mol Biol
Ramírez-Expósito MJ, Cueto-Ureña C, Martínez-Martos JM.   +2 more
europepmc   +1 more source

eIF3: a critical player in mRNA recruitment to the ribosome with emerging roles across translation. [PDF]

Biochem Soc Trans
Ide NA, Noorwez S, Xu C, Aitken CE.
europepmc   +1 more source