Protein synthesis by ribosomes with tethered subunits [PDF]
Nature, 2015 The ribosome is a ribonucleoprotein machine responsible for protein synthesis. In all kingdoms of life it is composed of two subunits, each built on its own ribosomal RNA (rRNA) scaffold. The independent but coordinated functions of the subunits, including their ability to associate at initiation, rotate during elongation, and dissociate after protein ...
Orelle, Cédric +5 more
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Journal of Tropical Life Science, 2017 Shigella flexneri is the most common causal agent of shigellosis. Its pili are composed of pili protein subunits. Adhesion molecules can be found on the pili and outer membrane proteins (Omp).
Avin Ainur Fitrianingsih +6 more
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Subunits of the Drosophila actin-capping protein heterodimer regulate each other at multiple levels.
PLoS ONE, 2014 The actin-Capping Protein heterodimer, composed of the α and β subunits, is a master F-actin regulator. In addition to its role in many cellular processes, Capping Protein acts as a main tumor suppressor module in Drosophila and in humans, in part, by ...
Ana Rita Amândio +3 more
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Mitochondrial ribosome assembly in Neurospora. Structural analysis of mature and partially assembled ribosomal subunits by equilibrium centrifugation in CsCl gradients [PDF]
, 1982 In Neurospora, one protein associated with the mitochondrial small ribosomal subunit (S-5, Mr 52,000) is synthesized intramitochondrially and is assumed to be encoded by mtDNA.
Lambowitz, Alan M., LaPolla, Robert J.
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Tissue-specific expression of calcium channels [PDF]
, 1993 The high-voltage-activated calcium channel is a multimeric protein complex containing 1, 2/δ, β, and γ subunits. The 1 subunit is the ion conduction channel and contains the binding sites for calcium channel blockers and toxins.
Biel +59 more
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Visualization of the exocyst complex dynamics at the plasma membrane of Arabidopsis thaliana [PDF]
, 2013 The exocyst complex, an effector of Rho and Rab GTPases, is believed to function as an exocytotic vesicle tether at the plasma membrane before soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex formation.
De Rycke, Riet +7 more
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Footprints of Optimal Protein Assembly Strategies in the Operonic Structure of Prokaryotes
Metabolites, 2015 In this work, we investigate optimality principles behind synthesis strategies for protein complexes using a dynamic optimization approach. We show that the cellular capacity of protein synthesis has a strong influence on optimal synthesis strategies ...
Jan Ewald +3 more
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USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit
eLife, 2020 Establishment of translational competence represents a decisive cytoplasmic step in the biogenesis of 40S ribosomal subunits. This involves final 18S rRNA processing and release of residual biogenesis factors, including the protein kinase RIOK1.
Christian Montellese +9 more
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60S dynamic state of bacterial ribosome is fixed by yeast mitochondrial initiation factor 3 [PDF]
PeerJ, 2018 The processes of association and dissociation of ribosomal subunits are of great importance for the protein biosynthesis. The mechanistic details of these processes, however, are not well known.
Sergey Levitskii +7 more
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Studies of NMDA receptor function and stoichiometry with truncated and tandem subunits [PDF]
, 2003 The subunits that compose eukaryotic glutamate ion channel receptors have three transmembrane domains (TMs) and terminate with intracellular tails that are important for controlling channel expression and localization.
Colquhoun, D., Schorge, S.
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