Results 21 to 30 of about 450,139 (318)
Footprints of Optimal Protein Assembly Strategies in the Operonic Structure of Prokaryotes
Metabolites, 2015 In this work, we investigate optimality principles behind synthesis strategies for protein complexes using a dynamic optimization approach. We show that the cellular capacity of protein synthesis has a strong influence on optimal synthesis strategies ...
Jan Ewald +3 more
doaj +1 more source
Protein Kinase A Regulatory Subunits in Colon Cancer
Neoplasia: An International Journal for Oncology Research, 1999 The protein kinase A (PKA) is classified as type I or II depending on the association of the catalytic subunit with either the RI or RII regulatory subunits.
Chris C. Carlson +4 more
doaj +1 more source
Scientific Reports, 2017 Somatic mutations in protein kinase A catalytic α subunit (PRKACA) were found to be causative for 30–40% of cortisol-producing adenomas (CPA) of the adrenal gland, rendering PKA signalling constitutively active.
Isabel Weigand +11 more
doaj +1 more source
Accessory proteins for heterotrimeric G-proteins in the kidney
Frontiers in Physiology, 2015 Heterotrimeric G-proteins play a fundamentally important role in regulating signal transduction pathways in the kidney. Accessory proteins are being identified as direct binding partners for heterotrimeric G-protein α or βγ subunits to promote more ...
Frank ePark
doaj +1 more source
Conservation of helical bundle structure between the exocyst subunits.
PLoS ONE, 2009 BackgroundThe exocyst is a large hetero-octomeric protein complex required for regulating the targeting and fusion of secretory vesicles to the plasma membrane in eukaryotic cells.
Nicole J Croteau +3 more
doaj +1 more source
Research progress of the Elongator complex in plant
Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2023 The Elongator complex consists of six subunits (ELP1-ELP6), where ELP1-ELP3 forms the core subcomplex and ELP4-ELP6 forms the auxiliary subcomplex. Deletion of any of the six subunits results in an almost identical phenotype, suggesting that all six ...
Ji XIANGZHUO +4 more
doaj +1 more source
SWI/SNF Infobase-An exclusive information portal for SWI/SNF remodeling complex subunits. [PDF]
PLoS ONE, 2017 Chromatin remodeling complexes facilitate the access of condensed genomic DNA during transcription, replication, and repair, by altering the histone-DNA contacts in the nucleosome structures.
Udayakumar Mani +3 more
doaj +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Stepwise order in protein complex assembly: approaches and emerging themes
Open BiologyProtein-based nanomachines drive every cellular process. An explosion of high-resolution structures of multiprotein complexes has improved our understanding of what these machines look like and how they work, but we still know relatively little about how
Michael T. Brown, Michael A. McMurray
doaj +1 more source
Neurobiology of Disease, 2004 Alzheimer's disease (AD) is characterized by loss of specific cell populations within selective subregions of the hippocampus. Excitotoxicity, mediated via ionotropic glutamate receptors, may play a crucial role in this selective neuronal vulnerability ...
Amanda J Mishizen-Eberz +5 more
doaj +1 more source