Results 71 to 80 of about 450,139 (318)

Sequential replacement of PSD95 subunits in postsynaptic supercomplexes is slowest in the cortex

eLife
The concept that dimeric protein complexes in synapses can sequentially replace their subunits has been a cornerstone of Francis Crick’s 1984 hypothesis, explaining how long-term memories could be maintained in the face of short protein lifetimes ...
Katie Morris, Edita Bulovaite, Takeshi Kaizuka, Sebastian Schnorrenberg, Candace T Adams, Noboru Komiyama, Lorena Mendive-Tapia, Seth GN Grant, Mathew H Horrocks   +8 more
doaj   +1 more source

Analysis of subunit folding contribution of three yeast large ribosomal subunit proteins required for stabilisation and processing of intermediate nuclear rRNA precursors

, 2021
Gisela Pöll, Michael Pilsl, Joachim Griesenbeck, Herbert Tschochner, Philipp Milkereit   +4 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Supernumerary proteins of the human mitochondrial ribosomal small subunit are integral for assembly and translation

iScience
Summary: Mitochondrial ribosomes (mitoribosomes) have undergone substantial evolutionary structural remodeling accompanied by loss of ribosomal RNA, while acquiring unique protein subunits located on the periphery.
Taru Hilander, Ryan Awadhpersad, Geoffray Monteuuis, Krystyna L. Broda, Max Pohjanpelto, Elizabeth Pyman, Sachin Kumar Singh, Tuula A. Nyman, Isabelle Crevel, Robert W. Taylor, Ann Saada, Diego Balboa, Brendan J. Battersby, Christopher B. Jackson, Christopher J. Carroll   +14 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Comparing the Effect of Ionizing Radiations of Electron Beam and Gamma Ray on Ruminal Degradation Kinetics of Soybean Meal Protein and Amino acids

پژوهشهای علوم دامی ایران, 2014
This research was conducted to compare effects of electron beam (EB) and gamma ray (GR) treatments at doses of 25, 50 and 75 kGy on soybean meal (SBM) ruminal degradation kinetics of crude protein (CP) and amino acids (AA).
Farzad Ghanbari, T. Ghoorchi, Parvin Shawrang, Noor-Mohammad Torbatinejad   +3 more
doaj  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

A mathematical model of protein subunits COVID-19 vaccines. [PDF]

Math Biosci, 2023
Gholami S, Korosec CS, Farhang-Sardroodi S, Dick DW, Craig M, Ghaemi MS, Ooi HK, Heffernan JM.   +7 more
europepmc   +1 more source

The G Protein Subunit Gene Families

Genomics, 1999
t i t u p g s t ( uch as neurotransmitters, hormones, and light. The vast ajority of such receptors are coupled to G proteins, which ransduce the signal to effectors. G proteins are heterotrimrs made up of an a, a b, and a g subunit (29). The G protein ubunits are now known to be encoded by families of related enes in mammalian cells (74). The sizes of
G B, Downes, N, Gautam
openaire   +2 more sources