Results 191 to 200 of about 3,768,680 (342)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Genome-wide landscape of RNA-binding protein target site dysregulation reveals a major impact on psychiatric disorder risk. [PDF]

Nat Genet, 2021
Park CY, Zhou J, Wong AK, Chen KM, Theesfeld CL, Darnell RB, Troyanskaya OG.   +6 more
europepmc   +1 more source

Cell Surface Targeting of Heat Shock Protein gp96 Induces Dendritic Cell Maturation and Antitumor Immunity [PDF]

, 2001
Hong Zheng, Jie Dai, Diliana Stoilova, Zihai Li   +3 more
openalex   +1 more source

Supplementary Figure 3A-C from Hypoxia-Inducible Protein 2 (<i>HIG2</i>), a Novel Diagnostic Marker for Renal Cell Carcinoma and Potential Target for Molecular Therapy

, 2023
Akira Togashi, Toyomasa Katagiri, Shingo Ashida, Tomoaki Fujioka, Osamu Maruyama, Yoshiaki Wakumoto, Yoshiro Sakamoto, Μakoto Fujime, Yoshio Kawachi, Taro Shuin, Yusuke Nakamura   +10 more
openalex   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Bacterial ubiquitin ligase engineered for small molecule and protein target identification. [PDF]

EMBO J
Ye JS, Majumdar A, Park BC, Black MH, Hsieh TS, Osinski A, Servage KA, Kulkarni K, Naidoo J, Alto NM, Stratton MM, Alfandari D, Ready JM, Pawłowski K, Tomchick DR, Tagliabracci VS.   +15 more
europepmc   +1 more source

Supplementary Figure 3 from Atu027, a Liposomal Small Interfering RNA Formulation Targeting Protein Kinase N3, Inhibits Cancer Progression

, 2023
Manuela Aleku, Petra Schulz, Oliver Keil, Ansgar Santel, Ute Schaeper, Britta Dieckhoff, Oliver Janke, Jens Endruschat, Birgit Durieux, Nadine Röder, Kathrin Löffler, Christian Lange, Melanie Fechtner, Kristin Möpert, Gerald Fisch, Sibylle Dames, W. Arnold, Karin Jochims, Klaus Giese, Bertram Wiedenmann, Arne Scholz, Jörg Kaufmann   +21 more
openalex   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Protein Target Highlights in CASP16: Insights From the Structure Providers. [PDF]

Proteins
Alexander LT, Follonier OM, Kryshtafovych A, Abesamis K, Bibi-Triki S, Box HG, Breyton C, Bringel F, Carrique L, d'Acapito A, Dong G, DuBois R, Fass D, Fiesco JM, Fox DR, Grimes JM, Grinter R, Jenkins M, Kamyshinsky R, Keown JR, Lackner G, Lammers M, Liu S, Lovering AL, Malinauskas T, Masquida B, Palm GJ, Siebold C, Su T, Zhang P, Zhou ZH, Fidelis K, Topf M, Moult J, Schwede T.   +34 more
europepmc   +1 more source

Thieno[2,3-c]pyridine Hybrids Inspired by Prasugrel and Telmisartan: Design, Synthesis, and Molecular Docking Studies Targeting SARS-CoV-2 Spike Protein and 3CLpro

Selvaraj Kanchithalaivan, Malaisamy Arunkumar, Singanan Ponnuchamy, Manikka Kubendran Aravind, Balasubramaniem Ashokkumar, Raju Ranjith Kumar   +5 more
openalex   +1 more source