Results 211 to 220 of about 2,449,011 (263)
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Targeting of lysosomal proteins
Seminars in Cell & Developmental Biology, 2000Proper cell homeostasis requires the efficient transport of a large variety of soluble acid hydrolases and transmembrane proteins from the trans-Golgi network (TGN) to lysosomes. While most of these molecules reach this degradative compartment, some transmembrane proteins, in particular, the acid hydrolase receptors are retrieved to the TGN.
Y, Rouillé, W, Rohn, B, Hoflack
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Science, 1996
Microtubules are responsible for chromosome segregation and the movement and reorganization of membranous organelles. Many aspects of microtubule-based motility can be attributed to the action of motor proteins, producing force directed toward either end of microtubules.
R B, Vallee, M P, Sheetz
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Microtubules are responsible for chromosome segregation and the movement and reorganization of membranous organelles. Many aspects of microtubule-based motility can be attributed to the action of motor proteins, producing force directed toward either end of microtubules.
R B, Vallee, M P, Sheetz
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Protein targeting and protein secretion
Genome, 1989The two scheduled workshops entitled Protein Secretion and Protein Targeting were combined into a single session on Monday, August 22, before a large audience. We record here the highlights of these talks, which supplement the information already available in the published abstracts.
M E, Dumont, F, Sherman, D Y, Thomas
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Protein Targeting in the Neuron
Annual Review of Neuroscience, 1993The morphology of the neuron is essential to its function. Each mor phological specialization of the neuron, the dendrite, the dendritic spines, the axon, the axon hillock, the nodes of Ranvier, the active zone, and the synaptic vesicle appears to have a unique protein composition.
R B, Kelly, E, Grote
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Proteolysis-targeting Chimeras for Targeting Protein for Degradation
Future Medicinal Chemistry, 2019Proteolysis-targeting chimeras (PROTACs) are an emerging tool for therapeutic intervention by reducing or eliminating disease-causing proteins. PROTACs are bifunctional molecules that consist of a target protein ligand, a linker and an E3 ligase ligand, which mediate the polyubiquitination of the target protein, ultimately leading to the target protein
Jianguo, Qi, Gang, Zhang
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Protein–Protein Interactions as Drug Targets
Future Medicinal Chemistry, 2015Modulation of protein-protein interactions (PPIs) is becoming increasingly important in drug discovery and chemical biology. While a few years ago this 'target class' was deemed to be largely undruggable an impressing number of publications and success stories now show that targeting PPIs with small, drug-like molecules indeed is a feasible approach ...
Skwarczynska, Malgorzata +1 more
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Current Opinion in Chemical Biology, 2005
The ubiquitin-proteasome pathway plays a major role in cellular protein destruction and regulates fundamental cellular processes such as the cell cycle, cell signaling, and development. By altering the substrate recognition of ubiquitin-protein ligases, their robust proteolytic activity can be re-directed to recruit and accelerate the degradation of ...
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The ubiquitin-proteasome pathway plays a major role in cellular protein destruction and regulates fundamental cellular processes such as the cell cycle, cell signaling, and development. By altering the substrate recognition of ubiquitin-protein ligases, their robust proteolytic activity can be re-directed to recruit and accelerate the degradation of ...
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On‐target ultrasonic digestion of proteins
PROTEOMICS, 2013In the present work, we report a novel on‐target protein cleavage method. The method utilizes ultrasonic energy and allows up to 20 samples to be cleaved in 5 min for protein identification and one sample in 30 s for on‐tissue digestion. The standard proteins were spotted on a conductive glass slide in a volume of 0.5 μL followed by 5 min of ...
Santos, Hugo M. +3 more
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Drugs Targeting Protein—Protein Interactions
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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Protein Targeting to Yeast Peroxisomes
2007Peroxisomes are important organelles of eukaryote cells. Although these structures are of relatively small size, they display an unprecedented functional versatility. The principles of their biogenesis and function are strongly conserved from very simple eukaryotes to humans.
van der Klei, Ida, Veenhuis, Marten
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