Results 211 to 220 of about 3,768,680 (342)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Exploration of Multiconformers to Extract Information About Structural Deformation Undergone by a Protein Target: Illustration on the Bcl-xL Target. [PDF]

Molecules
Baillif M, Tempez E, Badel A, Regad L.
europepmc   +1 more source

Bioactivity of melianone against Salmonella and in silico prediction of a membrane protein target. [PDF]

3 Biotech, 2020
Veni A, Lokeswari TS, Krishna Kumari GN, Gayathri D, Sudandiradoss C.   +4 more
europepmc   +1 more source

Supplementary Methods, Figures 1-2 from Targeted Inhibition of Replication Protein A Reveals Cytotoxic Activity, Synergy with Chemotherapeutic DNA-Damaging Agents, and Insight into Cellular Function

, 2023
Sarah C. Shuck, John J. Turchi
openalex   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Identification of AIF1 as a protein target of notoginsenosides in brain tissue of mice with intracerebral hemorrhage based on hapten immunoaffinity fishing technique. [PDF]

J Ginseng Res
Chen F, Qin W, Li Q, Li C, Chen C, Chen L, Yao Q, Zhu Z, Zhao Y.   +8 more
europepmc   +1 more source

Supplementary Tables 1-2, Appendix materials, Figures 1-2 from <i>In vitro</i> and <i>In vivo</i> Activity of Novel Small-Molecule Inhibitors Targeting the Pleckstrin Homology Domain of Protein Kinase B/AKT

, 2023
Sylvestor A. Moses, M. Ahad Ali, Zuohe Song, Lei Du‐Cuny, Li Zhou, Robert Lemos, Nathan T. Ihle, A. Geoffrey Skillman, Shuxing Zhang, Eugene A. Mash, Garth Powis, Emmanuelle J. Meuillet   +11 more
openalex   +2 more sources

Keeping Proteins on Target

PLoS Biology, 2004
openaire   +3 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Identifying ENO1 as a protein target of chlorogenic acid to inhibit cellular senescence and prevent skin photoaging in mice. [PDF]

Aging Cell
He X, Wang C, Zhang Q, Yang T, Guo Q, Wang Y, Guo J, Wang P, Zhang J, Tang H, Zhu Y, Wang J.   +11 more
europepmc   +1 more source