Results 201 to 210 of about 3,768,680 (342)

Supplementary Figure 4 from Atu027, a Liposomal Small Interfering RNA Formulation Targeting Protein Kinase N3, Inhibits Cancer Progression

, 2023
Manuela Aleku, Petra Schulz, Oliver Keil, Ansgar Santel, Ute Schaeper, Britta Dieckhoff, Oliver Janke, Jens Endruschat, Birgit Durieux, Nadine Röder, Kathrin Löffler, Christian Lange, Melanie Fechtner, Kristin Möpert, Gerald Fisch, Sibylle Dames, W. Arnold, Karin Jochims, Klaus Giese, Bertram Wiedenmann, Arne Scholz, Jörg Kaufmann   +21 more
openalex   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Data from Regulation of Microtubule-Dependent Protein Transport by the TSC2/Mammalian Target of Rapamycin Pathway

, 2023
Xiuyun Jiang, Raymond S. Yeung
openalex   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Binding mechanism and structural insights into the identified protein target of COVID-19 and importin-α with <i>in-vitro</i> effective drug ivermectin. [PDF]

J Biomol Struct Dyn, 2022
Sen Gupta PS, Biswal S, Panda SK, Ray AK, Rana MK.   +4 more
europepmc   +1 more source

Validation of the protein-protein interaction of A-kinase anchoring protein AKAP18 with protein kinase A as a target for the therapy of heart failure

, 2021
Enno Klußmann
openalex  

Data from A Transcriptional Profiling Study of CCAAT/Enhancer Binding Protein Targets Identifies Hepatocyte Nuclear Factor 3β as a Novel Tumor Suppressor in Lung Cancer

, 2023
Balázs Halmos, Daniela S. Daniela Sanchez Bassères, Stefano Monti, Francesco D‘Aló, Tajhal Dayaram, Katalin Ferenczi, Bas J. Wouters, Claudia S. Huettner, Todd R. Golub, Daniel G. Tenen   +9 more
openalex   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

TMT-based proteomics analysis identifies RPLP1 as a key protein target in ursolic acid Inhibition of colorectal cancer. [PDF]

Discov Oncol
Zhu LM, Shi HX, Xu ZY, Deng HB.
europepmc   +1 more source

Supplementary Figures 1-4 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer

, 2023
Isabelle Bernard‐Pierrot, Nadège Gruel, Nicolas Stransky, Anne Vincent‐Salomon, Fabien Reyal, Virginie Raynal, Céline Vallot, Gaëlle Pierron, François Radvanyi, Olivier Delattre   +9 more
openalex   +1 more source