Results 211 to 220 of about 13,924,024 (337)

Deep neural networks for interpreting RNA-binding protein target preferences. [PDF]

Genome Res, 2020
Ghanbari M, Ohler U.
europepmc   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Protein target search diffusion-association/dissociation free energy landscape around DNA binding site with flanking sequences. [PDF]

Biophys J
Wan B, Yu J.
europepmc   +1 more source

Identification of phytochemicals as potential therapeutic agents that binds to Nsp15 protein target of coronavirus (SARS-CoV-2) that are capable of inhibiting virus replication. [PDF]

Phytomedicine, 2021
Kumar S, Kashyap P, Chowdhury S, Kumar S, Panwar A, Kumar A.   +5 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Cytotoxicity and molecular docking analysis of phytochemicals from <i>Vallisneria spiralis</i> with protein target 3CZH in breast cancer management. [PDF]

Bioinformation
Waykar R, Kumarapillai S.
europepmc   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Insights into amyloid precursor protein target through PPI network analysis. [PDF]

Bioinformation
Grewal A, Sheokand D, Chauhan R, Saini V, Kumar A.   +4 more
europepmc   +1 more source

Ultrastructural and proapoptotic-like effects of kaempferol in Giardia duodenalis trophozoites and bioinformatics prediction of its potential protein target. [PDF]

Mem Inst Oswaldo Cruz, 2020
Argüello-García R, Calzada F, García-Hernández N, Chávez-Munguía B, Velázquez-Domínguez JA.   +4 more
europepmc   +1 more source

Phthalimide conjugation as a strategy for in vivo target protein degradation

Science, 2015
Georg E. Winter, Dennis L. Buckley, Joshiawa Paulk, Justin M. Roberts, Amanda L. Souza, S. Dhe-Paganon, J. Bradner   +6 more
semanticscholar   +1 more source