Results 221 to 230 of about 13,924,024 (337)

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Study on the Chemical Composition and Anti-Tumor Mechanisms of Clausena lansium Fruit By-Products: Based on LC-MS, Network Pharmacology Analysis, and Protein Target Validation. [PDF]

Foods
Zhang Z, Zhang L, Wu P, Tian Y, Wen Y, Xu M, Xu P, Jiang Y, Ma N, Wang Q, Dai W.   +10 more
europepmc   +1 more source

oRNAment: a database of putative RNA binding protein target sites in the transcriptomes of model species. [PDF]

Nucleic Acids Res, 2020
Benoit Bouvrette LP, Bovaird S, Blanchette M, Lécuyer E.   +3 more
europepmc   +1 more source

MERS-CoV spike protein: a key target for antivirals

Expert opinion on therapeutic targets, 2017
L. Du, Yang Yang, Yusen Zhou, Lu Lu, Fang Li, Shibo Jiang   +5 more
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Protein target similarity is positive predictor of in vitro antipathogenic activity: a drug repurposing strategy for Plasmodium falciparum. [PDF]

J Cheminform
Mogire RM, Miruka SA, Juma DW, McNamara CW, Andagalu B, Burrows JN, Chenu E, Duffy J, Ogutu BR, Akala HM.   +9 more
europepmc   +1 more source

Unexpected fold in the circumsporozoite protein target of malaria vaccines

Proceedings of the National Academy of Sciences of the United States of America, 2012
Michael B. Doud, A. Koksal, L. Mi, Gaojie Song, Chafen Lu, T. Springer   +5 more
semanticscholar   +1 more source

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Nature Metabolism, 2020
L. Folkersen, S. Gustafsson, Qin Wang, Daniel Hvidberg Hansen, Å. Hedman, A. Schork, K. Page, D. Zhernakova, Yang Wu, J. Peters, N. Eriksson, Sarah L Bergen, Thibaud S. Boutin, A. Bretherick, Stefan Enroth, A. Kalnapenkis, J. Gådin, B. Suur, Yan Chen, L. Matic, J. Gale, Julie Lee, Weidong Zhang, A. Quazi, M. Ala-Korpela, S. Choi, A. Claringbould, J. Danesh, G. Davey Smith, Federico De Masi, S. Elmståhl, G. Engström, E. Fauman, C. Fernandez, L. Franke, P. Franks, V. Giedraitis, C. Haley, A. Hamsten, A. Ingason, Å. Johansson, Peter K. Joshi, L. Lind, C. Lindgren, S. Lubitz, T. Palmer, E. Macdonald-Dunlop, M. Magnusson, O. Melander, K. Michaelsson, A. Morris, R. Mägi, Michael W. Nagle, P. Nilsson, J. Nilsson, M. Orho-Melander, O. Polašek, B. Prins, E. Pålsson, Ting Qi, M. Sjögren, J. Sundström, P. Surendran, U. Võsa, T. Werge, Rasmus Wernersson, H. Westra, Jian Yang, A. Zhernakova, J. Ärnlöv, Jingyuan Fu, J. Smith, T. Esko, C. Hayward, U. Gyllensten, M. Landén, A. Siegbahn, James F. Wilson, L. Wallentin, A. Butterworth, M. Holmes, E. Ingelsson, A. Mälarstig   +82 more
semanticscholar   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

PAR-dCLIP: Enabling detection of RNA binding protein target transcripts bound at 5' termini through the incorporation of a decapping step. [PDF]

Methods Enzymol
Lisy S, Rothamel K, Perevalova-Pinzul Y, Ascano M.   +3 more
europepmc   +1 more source