Results 61 to 70 of about 13,924,024 (337)

Adverse Drug Reaction Prediction Using Scores Produced by Large-Scale Drug-Protein Target Docking on High-Performance Computing Machines

PLoS ONE, 2014
Late-stage or post-market identification of adverse drug reactions (ADRs) is a significant public health issue and a source of major economic liability for drug development. Thus, reliable in silico screening of drug candidates for possible ADRs would be
M. LaBute, Xiaohua Zhang, J. Lenderman, B. Bennion, Sergio E. Wong, F. Lightstone   +5 more
semanticscholar   +1 more source

Target Misfolded Protein Clearance Pathway for Cancer Therapy

Proceedings, 2020
The role of RNA-dependent protein kinase R (PKR) and its association with misfolded protein expression in cancer cells are unclear. Herein we report that PKR regulates misfolded protein clearance by preventing it release through exosomes and promoting ...
Apar Pataer
doaj   +1 more source

C-reactive protein: pathogenetic characteristics and possible therapeutic target

Российский кардиологический журнал, 2021
It is known that the key mediator of acute phase response and marker of inflammation is C-reactive protein (CRP), the study of the role of which in the development of not only cardiovascular, but also infectious diseases has acquired particular relevance
E. A. Utkina, O. I. Afanasyeva, S. N. Pokrovsky   +2 more
doaj   +1 more source

USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling [PDF]

, 2014
Protein kinase ALK3/BMPR1A mediates bone morphogenetic protein (BMP) signalling through phosphorylation and activation of SMADs 1/5/8. SMAD6, a transcriptional target of BMP, negatively regulates the BMP pathway by recruiting E3 ubiquitin ligases and ...
Al-Salihi, Mazin A., Bruce, David, Cummins, Timothy D., Dingwell, Kevin S., Ewan, Richard, Herhaus, Lina, Macartney, Thomas, Sapkota, Gopal P., Smith, James C., Vogt, Janis, Wasmus, Lise, Weidlich, Simone   +11 more
core   +3 more sources

Blind docking methods have been inappropriately used in most network pharmacology analysis

Frontiers in Pharmacology
Network pharmacology methods have bridged the gap between traditional Chinese medicine (TCM) theory and contemporary pharmacological research and have been widely used in the study of multi-component, multi-target mechanisms of action of TCM.
Xinhao Che, Lei Zhang
doaj   +1 more source

Protein phosphorylation: A potential target in glioma development

Ibrain, 2022
Glioma is one of the most common primary brain tumors, and mortality due to this disease is second only to cardiovascular and cerebrovascular diseases. In traditional surgery, it is difficult to eradicate glioma; often recurrence increases its malignant ...
Yu Pi, Chang‐Le Fang, Zhang‐Yu Su
doaj   +1 more source

Synthesis of Epoxyoxirenes: Phytotoxic Activity and Enzymatic Target Identification

Plants
Chemical control is key to minimizing agricultural losses, driving the search for more efficient and selective herbicides. This study reports the synthesis of epoxyoxirenes, their phytotoxic evaluation, and an in silico analysis to identify the protein ...
Kamylla C. F. de Faria, Elson S. Alvarenga, Denilson F. Oliveira, Vitor C. Baia, Armin F. Isenmann   +4 more
doaj   +1 more source

A new target for G protein signaling

eLife, 2017
G protein-coupled receptor stimulation inhibits TRPM3 channel activity through direct binding of the Gβγ subunit to the channel.
László Csanády
doaj   +1 more source

Fibronectin leucine-rich transmembrane protein 2 drives monocyte differentiation into macrophages via the UNC5B-Akt/mTOR axis

Frontiers in Immunology, 2023
Upon migrating into the tissues, hematopoietic stem cell (HSC)-derived monocytes differentiate into macrophages, playing a crucial role in determining innate immune responses towards external pathogens and internal stimuli.
Yaxiong Fang, Kongyang Ma, Yi-Min Huang, Yuanye Dang, Zhaoyu Liu, Yiming Xu, Xi-Long Zheng, Xiangdong Yang, Yongliang Huo, Xiaoyan Dai   +9 more
doaj   +1 more source

Nutritional and Behavioral Intervention for Long‐Term Childhood Acute Leukemia Survivors With Metabolic Syndrome

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).
Visentin Sandrine, Béliard Sophie, Renard Cécile, Caussy Cyrielle, Hamidou Zeinab, Romano David, Gacem Mélanie, Petit Arnaud, Saultier Paul, Borentain Patrick, Michel Gérard   +10 more
wiley   +1 more source