Protein Interactome of Amyloid-β as a Therapeutic Target
Pharmaceuticals, 2023 The amyloid concept of Alzheimer’s disease (AD) assumes the β-amyloid peptide (Aβ) as the main pathogenic factor, which injures neural and other brain cells, causing their malfunction and death.
Vladimir F. Lazarev +4 more
doaj +1 more source
Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state [PDF]
, 2017 Human respiratory syncytial virus (RSV) is the main cause of lower respiratory tract infections in young children. The RSV fusion protein (F) is highly conserved and is the only viral membrane protein that is essential for infection.
Chen, Man +13 more
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Predicting Abdominal Aortic Aneurysm Target Genes by Level-2 Protein-Protein Interaction. [PDF]
PLoS ONE, 2015 Abdominal aortic aneurysm (AAA) is frequently lethal and has no effective pharmaceutical treatment, posing a great threat to human health. Previous bioinformatics studies of the mechanisms underlying AAA relied largely on the detection of direct protein ...
Kexin Zhang +4 more
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Fusion of Sendai virus with the target cell membrane is required for T cell cytotoxicity [PDF]
, 1978 INFECTION of mice with viruses can generate cytotoxic T lymphocytes (CTL) which show restricted specificity for target cell lysis. Specific lysis requires that the virus used to prime the target cells must be of the same type as that used to sensitise ...
A Munro +12 more
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Identification of oleoylethanolamide as an endogenous ligand for HIF-3α
Nature Communications, 2022 Whether hypoxia-inducible factors (HIFs) can be directly regulated by endogenous small molecules is a long-standing question. Here authors identified the metabolite oleoylethanolamide as a HIF-3α ligand and further revealed its mechanism of action.
Xiaotong Diao +15 more
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Aptamer-based cell-free detection system to detect target protein
Synthetic and Systems Biotechnology, 2021 Biomarkers of disease, especially protein, show great potential for diagnosis and prognosis. For detecting a certain protein, a binding assay implementing antibodies is commonly performed.
Junhong Chen +6 more
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USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling [PDF]
, 2014 Protein kinase ALK3/BMPR1A mediates bone morphogenetic protein (BMP) signalling through phosphorylation and activation of SMADs 1/5/8. SMAD6, a transcriptional target of BMP, negatively regulates the BMP pathway by recruiting E3 ubiquitin ligases and ...
Al-Salihi, Mazin A. +11 more
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Prediction of regulatory targets of alternative isoforms of the epidermal growth factor receptor in a glioblastoma cell line. [PDF]
, 2019 BackgroundThe epidermal growth factor receptor (EGFR) is a major regulator of proliferation in tumor cells. Elevated expression levels of EGFR are associated with prognosis and clinical outcomes of patients in a variety of tumor types. There are at least
Ardell, David H +7 more
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Properties of protein drug target classes.
PLoS ONE, 2015 Accurate identification of drug targets is a crucial part of any drug development program. We mined the human proteome to discover properties of proteins that may be important in determining their suitability for pharmaceutical modulation.
Simon C Bull, Andrew J Doig
doaj +1 more source
Protein-based molecular contrast optical coherence tomography with phytochrome as the contrast agent [PDF]
, 2004 We report the use of phytochrome A (phyA), a plant protein that can reversibly switch between two states with different absorption maxima (at 660 and 730 nm), as a contrast agent for molecular contrast optical coherence tomography (MCOCT).
Choma, Michael A. +4 more
core +1 more source