Results 61 to 70 of about 3,768,680 (342)

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Ultrasound-actuated platelet mimetic nanomotors enable targeted piezocatalytic ROS storm for precision thrombolysis

Journal of Nanobiotechnology
Thrombotic diseases pose life-threatening risks, yet current thrombolytic therapies face limitations including poor targeting and bleeding risks. To address this, ultrasound-activatable nanomotors (hBT-Pt@Pm) were developed through the integration of ...
Ye Zhao, Jinchen He, Yuxi Liu, Hassna Soummane, Pan Ran, Qian Yang, Xiaofang Gao, Wenxiong Cao, Long Zhao   +8 more
doaj   +1 more source

An Evolutionary Approach to Drug-Design Using Quantam Binary Particle Swarm Optimization Algorithm

, 2012
The present work provides a new approach to evolve ligand structures which represent possible drug to be docked to the active site of the target protein. The structure is represented as a tree where each non-empty node represents a functional group.
Chowdhury, Arkabandhu, Ghosh, Arnab, Ghosh, Avishek, Hazra, Jubin   +3 more
core   +1 more source

Label-free biosensors for the detection and quantification of cardiovascular risk markers [PDF]

, 2008
This paper presents a biosensor implementation for the detection of protein molecules using specific antibodies. Affinity sensors allow the detection and quantification of target molecules in complex mixtures by affinity-based interactions.
Başağa, Hüveyda, Gül, Özgür, Gürbüz, Yaşar, Kallempudi, Sreenivasa Saravan, Sezerman, Uğur   +4 more
core   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Systematic Targeting of Protein–Protein Interactions [PDF]

Trends in Pharmacological Sciences, 2016
Over the past decade, protein-protein interactions (PPIs) have gone from being neglected as 'undruggable' to being considered attractive targets for the development of therapeutics. Recent advances in computational analysis, fragment-based screening, and molecular design have revealed promising strategies to address the basic molecular recognition ...
Ashley E, Modell, Sarah L, Blosser, Paramjit S, Arora   +2 more
openaire   +2 more sources

PROTACs targeting epigenetic proteins

Acta Materia Medica, 2023
The field of epigenetics pertains to alterations in gene function that are inherited without changes in the DNA sequence, including histone modifications, post-translational modifications of amino acids, and covalent modifications of DNA bases. These alteration pathways modulate the transformation of genotypes into specific phenotypes.
Chao Zhang, Yuna He, Xiuyun Sun, Wenyi Wei, Yanlong Liu, Yu Rao   +5 more
openaire   +3 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

DNA aptamers selectively target Leishmania infantum H2A protein. [PDF]

PLoS ONE, 2013
Parasites of the genus Leishmania produce leishmaniasis which affects millions people around the world. Understanding the molecular characteristics of the parasite can increase the knowledge about the mechanisms underlying disease development and ...
M Elena Martín, Marta García-Hernández, Eva M García-Recio, Gerónimo F Gómez-Chacón, Marta Sánchez-López, Víctor M González   +5 more
doaj   +1 more source

The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo [PDF]

, 2005
Maternal and zygotic activities of the homeodomain protein PAL-1 specify the identity and maintain the development of the multipotent C blastomere lineage in the C. elegans embryo. To identify PAL-1 regulatory target genes, we used microarrays to compare
Baugh, L. Ryan, Brown, Eugene L., Claggett, Julia M., Hill, Andrew A., Hill-Harfe, Kate, Hunter, Craig P., Slonim, Donna K., Wen, Joanne C.   +7 more
core   +1 more source