Results 51 to 60 of about 3,768,680 (342)
Co-targeting of DNA, RNA, and protein molecules provides optimal outcomes for treating osteosarcoma and pulmonary metastasis in spontaneous and experimental metastasis mouse models. [PDF]
, 2017 Metastasis is a major cause of mortality for cancer patients and remains as the greatest challenge in cancer therapy. Driven by multiple factors, metastasis may not be controlled by the inhibition of single target.
DeVere White, Ralph W +11 more
core +1 more source
Protein phosphorylation: A potential target in glioma development
Ibrain, 2022 Glioma is one of the most common primary brain tumors, and mortality due to this disease is second only to cardiovascular and cerebrovascular diseases. In traditional surgery, it is difficult to eradicate glioma; often recurrence increases its malignant ...
Yu Pi, Chang‐Le Fang, Zhang‐Yu Su
doaj +1 more source
C-reactive protein: pathogenetic characteristics and possible therapeutic target
Российский кардиологический журнал, 2021 It is known that the key mediator of acute phase response and marker of inflammation is C-reactive protein (CRP), the study of the role of which in the development of not only cardiovascular, but also infectious diseases has acquired particular relevance
E. A. Utkina +2 more
doaj +1 more source
Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1 [PDF]
, 2012 Loss of the tumor suppressor Pdcd4 was reported for various tumor entities and proposed as a prognostic marker in tumorigenesis. We previously characterized decreased Pdcd4 protein stability in response to mitogenic stimuli, which resulted from p70S6K1 ...
Bajer, Magdalena M. +11 more
core +3 more sources
Blind docking methods have been inappropriately used in most network pharmacology analysis
Frontiers in PharmacologyNetwork pharmacology methods have bridged the gap between traditional Chinese medicine (TCM) theory and contemporary pharmacological research and have been widely used in the study of multi-component, multi-target mechanisms of action of TCM.
Xinhao Che, Lei Zhang
doaj +1 more source
Supramolecular Chemistry Targeting Proteins
Journal of the American Chemical Society, 2017 The specific recognition of protein surface elements is a fundamental challenge in the life sciences. New developments in this field will form the basis of advanced therapeutic approaches and lead to applications such as sensors, affinity tags, immobilization techniques, and protein-based materials.
Sam van Dun +3 more
openaire +2 more sources
Synthesis of Epoxyoxirenes: Phytotoxic Activity and Enzymatic Target Identification
PlantsChemical control is key to minimizing agricultural losses, driving the search for more efficient and selective herbicides. This study reports the synthesis of epoxyoxirenes, their phytotoxic evaluation, and an in silico analysis to identify the protein ...
Kamylla C. F. de Faria +4 more
doaj +1 more source
A new target for G protein signaling
eLife, 2017 G protein-coupled receptor stimulation inhibits TRPM3 channel activity through direct binding of the Gβγ subunit to the channel.
László Csanády
doaj +1 more source
Protein Functional Families to characterise drug-target interactions. [PDF]
, 2017 The quest for “magic bullets” has been the driving force in drug discovery during the last two decades. However, the increasing rate of drug failure over this period has occurred concurrently with the assumption that a drug is a selective ligand for a ...
Moya-García, Aurelio
core
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács +8 more
wiley +1 more source