Results 31 to 40 of about 3,768,680 (342)

Targeting of proteins to the Golgi apparatus [PDF]

Glycoconjugate Journal, 1994
The Golgi apparatus maintains a highly organized structure in spite of the intense membrane traffic which flows into and out of this organelle. Resident Golgi proteins must have localization signals to ensure that they are targeted to the correct Golgi compartment and not swept further along the secretory pathway.
Gleeson, PA, Teasdale, RD, Burke, J
openaire   +4 more sources

Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons [PDF]

, 2014
Alternative splicing—the production of multiple messenger RNA isoforms from a single gene—is regulated in part by RNA binding proteins. While the RBPs transformer2 alpha (Tra2α) and Tra2β have both been implicated in the regulation of alternative ...
Austin, Caroline A., Best, Andrew, Chabot, Benoit, Cheong Lee, Ka, Cowell, Ian G., Curk, Tomaz, Dalgliesh, Caroline, Danilenko, Marina, Elliott, David J., Hong, Elaine, Hussain, Rafiq, James, Katherine, Keavney, Bernard, Kheirolahi-Kouhestani, Mahsa, Klinck, Roscoe, Santibanez Koref, Mauro, Tyson-Capper, Alison, Venables, Julian P., Wipat, Anil, Xu, Yaobo   +19 more
core   +2 more sources

Modeling protein target search in human chromosomes

Physical Review Research, 2021
Several processes in the cell, such as gene regulation, start when key proteins recognize and bind to short DNA sequences. However, as these sequences can be hundreds of million times shorter than the genome, they are hard to find by simple diffusion ...
Markus Nyberg, Tobias Ambjörnsson, Per Stenberg, Ludvig Lizana   +3 more
doaj   +1 more source

PRODUCTION OF SARS-COV-2 MEMBRANE PROTEIN AS BETTER TARGET PROTEIN FOR DIAGNOSTIC APPLICATION

International Journal of Infectious Diseases, 2023
Intro: The COVID-19 pandemic is caused by the SARS-CoV-2 virus, an enveloped RNA of the coronavirus family. The advancement in molecular technology and biochemistry has accelerated the development of diagnostic reagents and assays.
N.A. Mat Rahim, J. Zahidi, N.A. Amir Hashim, N.A. Nor Amdan, H.F. Zamri, M.R. Mohd Ali, R. Mohd Zain, N. Ahmad   +7 more
doaj   +1 more source

hMSCs treatment attenuates murine herpesvirus-68 (MHV-68) pneumonia through altering innate immune response via ROS/NLRP3 signaling pathway

Molecular Biomedicine, 2023
Immunocompromised individuals are particularly vulnerable to viral infections and reactivation, especially endogenous herpes viruses such as Epstein-Barr virus (EBV), a member of oncogenic gamma-herpesviruses, which are commonly linked to pneumonia and ...
Aiping Qin, Xiao-juan Wang, Jijun Fu, Ao Shen, Xiaotao Huang, Zhida Chen, Huiting Wu, Yu Jiang, Qian Wang, Fei Chen, Andy Peng Xiang, Xiyong Yu   +11 more
doaj   +1 more source

Polycation-π Interactions Are a Driving Force for Molecular Recognition by an Intrinsically Disordered Oncoprotein Family [PDF]

, 2013
Molecular recognition by intrinsically disordered proteins (IDPs) commonly involves specific localized contacts and target-induced disorder to order transitions.
A Arvand, A Bertolotti, A Bhattacherjee, A Boro, A Zarrine-Afsar, AB Sigalov, AG Turjanski, AH Mao, AH Mao, AK Dunker, AS Mahadevi, AS Reddy, AS Reddy, AY Tan, BA Shoemaker, C Haynes, D Alex, D Vijay, ED Ross, F Jin, G Gill, GM Lee, Guanghong Wei, HJ Dyson, HS Ashbaugh, HS Chan, HS Chan, Hue Sun Chan, HV Erkizan, HV Erkizan, I Staneva, J Danielsson, J Kim, J Singh, J Wang, J Wang, JC Hansen, JC Ma, JF Rual, Jianhui Song, JMR Baker, JP Gallivan, JP Gallivan, JS Barber-Rotenberg, JS Rao, JW Caldwell, Kevin A. W. Lee, KP Ng, KP Ng, KP Ng, L Feng, LM Iakoucheva, LM Salonen, M Azuma, M Borg, M Fuxreiter, M Levitt, MA Pufall, MS Cortese, MS Marshall, P Nash, P Tompa, P Tompa, PB Crowley, Peter Tompa, PJ Grohar, Q Lu, R Bachmaier, R Janknecht, R Petermann, R Wu, S Abeln, Sheung Chun Ng, SK Burley, SM Butterfield, T Mittag, T Mittag, V Neduva, VJ Hilser, VN Uversky, W Wang, W Zhong, X Chu, X Chu, X Xiu, Y Huang, Y Huang, Y Huang, Z Zhang   +88 more
core   +3 more sources

Hyperglycemia triggers HIPK2 protein degradation [PDF]

, 2016
Homeodomain interacting protein kinase-2 (HIPK2) is an evolutionary conserved kinase that modulates several key molecular pathways to restrain tumor growth and induce p53-depending apoptotic cell-death in response to anticancer therapies. HIPK2 silencing
Baldari, Silvia, Cirone, Mara, Cuomo, Laura, D'Orazi, Gabriella, Garufi, Alessia, Granato, Marisa, Pistritto, Giuseppa   +6 more
core   +2 more sources

A virus–target host proteins recognition method based on integrated complexes data and seed extension

BMC Bioinformatics, 2022
Background Target drugs play an important role in the clinical treatment of virus diseases. Virus-encoded proteins are widely used as targets for target drugs.
Shengrong Xia, Yingchun Xia, Chulei Xiang, Hui Wang, Chao Wang, Jin He, Guolong Shi, Lichuan Gu   +7 more
doaj   +1 more source

Transmembrane Protein TMEM230, a Target of Glioblastoma Therapy

Frontiers in Cellular Neuroscience, 2021
Glioblastomas (GBM) are the most aggressive tumors originating in the brain. Histopathologic features include circuitous, disorganized, and highly permeable blood vessels with intermittent blood flow.
Cinzia Cocola, Cinzia Cocola, Valerio Magnaghi, Edoardo Abeni, Paride Pelucchi, Valentina Martino, Laura Vilardo, Eleonora Piscitelli, Arianna Consiglio, Giorgio Grillo, Ettore Mosca, Roberta Gualtierotti, Daniela Mazzaccaro, Gina La Sala, Chiara Di Pietro, Mira Palizban, Sabino Liuni, Giuseppina DePedro, Stefano Morara, Giovanni Nano, Giovanni Nano, James Kehler, Burkhard Greve, Alessio Noghero, Alessio Noghero, Daniela Marazziti, Federico Bussolino, Federico Bussolino, Gianfranco Bellipanni, Igea D’Agnano, Martin Götte, Ileana Zucchi, Rolland Reinbold   +32 more
doaj   +1 more source

mRNA Display Design of Fibronectin-based Intrabodies That Detect and Inhibit Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein [PDF]

, 2009
The nucleocapsid (N) protein of severe acute respiratory syndrome (SARS) coronavirus plays important roles in both viral replication and modulation of host cell processes.
Amstutz, C. Anders Olson, Cardinale, Cardinale, Carlson, Carter, Chakrabarti, Chang, Chen, Elaine Wong, Enjuanes, Hongyu Deng, Hosse, Hsiang-I. Liao, Ja, Kawe, Koide, Lipovsek, Liu, Luo, Maynard, Milligan, Nizak, Olson, Olson, Rajpal, Ralph S. Baric, Ren Sun, Richard W. Roberts, Roberts, Roberts, Rota, Saikatendu, Satija, Seungmin Hwang, Stocks, Surjit, Vascotto, Visintin, Yount, Yu   +40 more
core   +4 more sources