Results 21 to 30 of about 2,545,960 (263)
BMC Bioinformatics, 2022 Background Target drugs play an important role in the clinical treatment of virus diseases. Virus-encoded proteins are widely used as targets for target drugs.
Shengrong Xia +7 more
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Aptamer-based cell-free detection system to detect target protein
Synthetic and Systems Biotechnology, 2021 Biomarkers of disease, especially protein, show great potential for diagnosis and prognosis. For detecting a certain protein, a binding assay implementing antibodies is commonly performed.
Junhong Chen +6 more
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Predicting Abdominal Aortic Aneurysm Target Genes by Level-2 Protein-Protein Interaction. [PDF]
PLoS ONE, 2015 Abdominal aortic aneurysm (AAA) is frequently lethal and has no effective pharmaceutical treatment, posing a great threat to human health. Previous bioinformatics studies of the mechanisms underlying AAA relied largely on the detection of direct protein ...
Kexin Zhang +4 more
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Properties of protein drug target classes.
PLoS ONE, 2015 Accurate identification of drug targets is a crucial part of any drug development program. We mined the human proteome to discover properties of proteins that may be important in determining their suitability for pharmaceutical modulation.
Simon C Bull, Andrew J Doig
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The role of serum exosomal miR-23a-3p and miR-375–3p in acute ischemic stroke
IBRO Neuroscience ReportsObjectives：Serum exosomal miRNAs are promising biomarkers and therapeutic targets for multiple diseases, but their expression profiles and functions in acute ischemic stroke (AIS) remain unclear. This study aimed to clarify the expression characteristics
Peng Ou +14 more
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Protein phosphorylation: A potential target in glioma development
Ibrain, 2022 Glioma is one of the most common primary brain tumors, and mortality due to this disease is second only to cardiovascular and cerebrovascular diseases. In traditional surgery, it is difficult to eradicate glioma; often recurrence increases its malignant ...
Yu Pi, Chang‐Le Fang, Zhang‐Yu Su
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C-reactive protein: pathogenetic characteristics and possible therapeutic target
Российский кардиологический журнал, 2021 It is known that the key mediator of acute phase response and marker of inflammation is C-reactive protein (CRP), the study of the role of which in the development of not only cardiovascular, but also infectious diseases has acquired particular relevance
E. A. Utkina +2 more
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Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin +17 more
wiley +1 more source
Blind docking methods have been inappropriately used in most network pharmacology analysis
Frontiers in PharmacologyNetwork pharmacology methods have bridged the gap between traditional Chinese medicine (TCM) theory and contemporary pharmacological research and have been widely used in the study of multi-component, multi-target mechanisms of action of TCM.
Xinhao Che, Lei Zhang
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad +9 more
wiley +1 more source