Results 21 to 30 of about 2,449,011 (263)
Targeting of proteins to the Golgi apparatus [PDF]
Glycoconjugate Journal, 1994 The Golgi apparatus maintains a highly organized structure in spite of the intense membrane traffic which flows into and out of this organelle. Resident Golgi proteins must have localization signals to ensure that they are targeted to the correct Golgi compartment and not swept further along the secretory pathway.
Gleeson, PA, Teasdale, RD, Burke, J
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Predicting Abdominal Aortic Aneurysm Target Genes by Level-2 Protein-Protein Interaction. [PDF]
PLoS ONE, 2015 Abdominal aortic aneurysm (AAA) is frequently lethal and has no effective pharmaceutical treatment, posing a great threat to human health. Previous bioinformatics studies of the mechanisms underlying AAA relied largely on the detection of direct protein ...
Kexin Zhang +4 more
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Aptamer-based cell-free detection system to detect target protein
Synthetic and Systems Biotechnology, 2021 Biomarkers of disease, especially protein, show great potential for diagnosis and prognosis. For detecting a certain protein, a binding assay implementing antibodies is commonly performed.
Junhong Chen +6 more
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Properties of protein drug target classes.
PLoS ONE, 2015 Accurate identification of drug targets is a crucial part of any drug development program. We mined the human proteome to discover properties of proteins that may be important in determining their suitability for pharmaceutical modulation.
Simon C Bull, Andrew J Doig
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Protein phosphorylation: A potential target in glioma development
Ibrain, 2022 Glioma is one of the most common primary brain tumors, and mortality due to this disease is second only to cardiovascular and cerebrovascular diseases. In traditional surgery, it is difficult to eradicate glioma; often recurrence increases its malignant ...
Yu Pi, Chang‐Le Fang, Zhang‐Yu Su
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C-reactive protein: pathogenetic characteristics and possible therapeutic target
Российский кардиологический журнал, 2021 It is known that the key mediator of acute phase response and marker of inflammation is C-reactive protein (CRP), the study of the role of which in the development of not only cardiovascular, but also infectious diseases has acquired particular relevance
E. A. Utkina +2 more
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The role of serum exosomal miR-23a-3p and miR-375–3p in acute ischemic stroke
IBRO Neuroscience ReportsObjectives：Serum exosomal miRNAs are promising biomarkers and therapeutic targets for multiple diseases, but their expression profiles and functions in acute ischemic stroke (AIS) remain unclear. This study aimed to clarify the expression characteristics
Peng Ou +14 more
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A new target for G protein signaling
eLife, 2017 G protein-coupled receptor stimulation inhibits TRPM3 channel activity through direct binding of the Gβγ subunit to the channel.
László Csanády
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar +7 more
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Blind docking methods have been inappropriately used in most network pharmacology analysis
Frontiers in PharmacologyNetwork pharmacology methods have bridged the gap between traditional Chinese medicine (TCM) theory and contemporary pharmacological research and have been widely used in the study of multi-component, multi-target mechanisms of action of TCM.
Xinhao Che, Lei Zhang
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