Results 21 to 30 of about 3,768,680 (342)

Targeting proteins for degradation [PDF]

Nature Chemical Biology, 2009
Protein degradation plays a central role in many cellular functions. Misfolded and damaged proteins are removed from the cell to avoid toxicity. The concentrations of regulatory proteins are adjusted by degradation at the appropriate time. Both foreign and native proteins are digested into small peptides as part of the adaptive immune response.
Erin K, Schrader, Kristine G, Harstad, Andreas, Matouschek   +2 more
openaire   +2 more sources

Structural basis for the broad and potent cross-reactivity of an N501Y-centric antibody against sarbecoviruses

Frontiers in Immunology, 2022
More than 80% of SARS-CoV-2 variants, including Alpha and Omicron, contain an N501Y mutation in the receptor-binding domain (RBD) of the spike protein. The N501Y change is an adaptive mutation enabling tighter interaction with the human ACE2 receptor. We
Bo-Seong Jeong, Joon Young Jeon, Chih-Jen Lai, Hye-Yeoung Yun, Jae U. Jung, Byung-Ha Oh, Byung-Ha Oh   +6 more
doaj   +1 more source

TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away

Cell Reports, 2023
Summary: Tripartite motif-containing protein 21 (TRIM21) is a cytosolic antibody receptor and E3 ubiquitin ligase that promotes destruction of a broad range of pathogens.
Tycho E.T. Mevissen, Anisa V. Prasad, Johannes C. Walter   +2 more
doaj   +1 more source

Protein phosphorylation in yeast mitochondria [PDF]

, 1987
We describe the identification and submitochondrial localization of four protein kinases and of their target proteins in derepressed yeast mitochondria. The activity of one of the kinases depends on the presence of cyclic AMP (cAMP).
Ashwell, Bandlow, Bandlow, Barrera, Bradford, Chandrasekaran, Chock, Daum, De Vendittis, Dimino, Douglas, Eraso, Fang, Heil, Henriksson, Hixson, Kim, Kitagawa, Krebs, Lastick, Linn, Mahler, Mahler, Matsumoto, Matsumoto, Matsumoto, Pall, Racker, Rigobello, Rittenhouse, Rödel, Steinberg, Steinberg, Suissa, Towbin, Van der Plaat, Vardanis, Wang   +37 more
core   +2 more sources

Targeting of proteins to mitochondria [PDF]

Biochemical Society Transactions, 2000
A clear picture has emerged over the past years on how a ‘classic’ mitochondrial protein, like subunit IV of cytochrome c oxidase, might be targeted to mitochondria. The targeting and subsequent import process involves the commitment of the TOM (ranslocase in the uter itochondrial membrane) receptor complex on the mitochondrial surface, a TIM ...
openaire   +2 more sources

GAPDOCK: A genetic algorithm approach to protein docking in CAPRI round 1 [PDF]

, 2003
As part of the first Critical Assessment of PRotein Interactions, round 1, we predict the structure of two protein-protein complexes, by using a genetic algorithm, GAPDOCK, in combination with surface complementarity, buried surface area, biochemical ...
Bailey, Connolly, Connolly, Dixon, Elsom, Fieulaine, Fieulaine, Gardiner, Grindley, Kraulis, Lawrence, Mathieu, Merritt, Russell, Smith, Strynadka, Tari, Vakser   +17 more
core   +1 more source

Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains

Cell Reports, 2021
Summary: Non-degradative ubiquitin chains and phosphorylation events govern signaling responses by innate immune receptors. The deubiquitinase CYLD in complex with SPATA2 is recruited to receptor signaling complexes by the ubiquitin ligase LUBAC and ...
Paul R. Elliott, Derek Leske, Jane Wagstaff, Lisa Schlicher, Georgina Berridge, Sarah Maslen, Frederik Timmermann, Biao Ma, Roman Fischer, Stefan M.V. Freund, David Komander, Mads Gyrd-Hansen   +11 more
doaj   +1 more source

Receptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cells. [PDF]

, 2005
BackgroundDeregulation of the Wnt/ beta-catenin signal transduction pathway has been implicated in the pathogenesis of tumours in the mammary gland, colon and other tissues. Mutations in components of this pathway result in beta-catenin stabilization and
Ashworth, Alan, Enver, Tariq, Kenny, Paraic A   +2 more
core   +3 more sources

Utilization of macrocyclic peptides to target protein-protein interactions in cancer

Frontiers in Oncology, 2022
Protein-protein interactions (PPIs) play vital roles in normal cellular processes. Dysregulated PPIs are involved in the process of various diseases, including cancer.
Jiawen Yang, Jiawen Yang, Jiawen Yang, Qiaoliang Zhu, Yifan Wu, Yifan Wu, Yifan Wu, Xiaojuan Qu, Xiaojuan Qu, Xiaojuan Qu, Haixia Liu, Haixia Liu, Haixia Liu, Biao Jiang, Biao Jiang, Di Ge, Xiaoling Song   +16 more
doaj   +1 more source

Stochastic model of transcription factor-regulated gene expression [PDF]

, 2006
We consider a stochastic model of transcription factor (TF)-regulated gene expression. The model describes two genes: Gene A and Gene B which synthesize the TFs and the target gene proteins respectively.
Alberts B, Bose I, Ferrer J, Fodde R, Ghosh B, Hume D A, Indrani Bose, Karmakar R, Kepler T B, Rajesh Karmakar, Santarosa M, Scott M   +11 more
core   +2 more sources