Results 1 to 10 of about 2,449,011 (263)
Ligands binding diffusively to protein target act as inhibitors of protein-protein interactions. [PDF]
PLoS Computational BiologyNuclear localization signal (NLS) sequence from capsid protein of Venezuelan equine encephalitis virus (VEEV) binds to importin-α transport protein and clogs nuclear import. Prevention of viral NLS binding to importin-α may represent a viable therapeutic
William Jeffries +12 more
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AI-first structural identification of pathogenic protein target interfaces. [PDF]
PLoS Computational BiologyThe risk of pandemics is increasing as global population growth and interconnectedness accelerate. Understanding the structural basis of protein-protein interactions between pathogens and hosts is critical for elucidating pathogenic mechanisms and ...
Mihkel Saluri +2 more
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Optimal TELSAM-Target Protein Linker Character is Target Protein-Dependent [PDF]
Structural DynamicsThe fusion of the sterile alpha motif domain of the human translocation ETS leukemia protein (TELSAM) to a protein of interest has been shown to significantly enhance crystallization propensity and improve diffraction quality.
Maria Jose P Romo +19 more
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Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus
Frontiers in Endocrinology, 2021 Type 2 diabetes Mellitus (T2DM) prevalence has significantly increased worldwide in recent years due to population age, obesity, and modern sedentary lifestyles. The projections estimate that 439 million people will be diabetic in 2030.
Karina Ramírez-Alarcón +14 more
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Communications Chemistry, 2021 Ortho functionalisation of phenols can be achieved using N-phenoxy amide directing groups. Here a method for chemodivergent C-H alkenylation, alkylation, carboetherification, or [3 + 2] annulation is presented, with product selectivity determined by the ...
Haiman Zhang +6 more
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Deubiquitinase-targeting chimeras for targeted protein stabilization [PDF]
Nature Chemical Biology, 2022 Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These diseases would be therapeutically benefited by targeted protein stabilization (TPS). Here we present deubiquitinase-targeting chimeras (DUBTACs), heterobifunctional small molecules consisting of a deubiquitinase recruiter linked to a protein-targeting ligand, to ...
Nathaniel J. Henning +23 more
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Advanced Science, 2022 Malignant proliferation and metastasis are the hallmarks of cancer cells. Aminated [70]fullerene exhibits notable antineoplastic effects, promoting it a candidate for multi‐targeted cancer drugs.
Jiawei Huo +16 more
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MG1141A as a Highly Potent Monoclonal Neutralizing Antibody Against SARS-CoV-2 Variants
Frontiers in Immunology, 2021 Since the coronavirus disease outbreak in 2019, several antibody therapeutics have been developed to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Antibody therapeutics are effective in neutralizing the virus and reducing
Sua Lee +19 more
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Frontiers in Immunology, 2022 More than 80% of SARS-CoV-2 variants, including Alpha and Omicron, contain an N501Y mutation in the receptor-binding domain (RBD) of the spike protein. The N501Y change is an adaptive mutation enabling tighter interaction with the human ACE2 receptor. We
Bo-Seong Jeong +6 more
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Targeting proteins for degradation [PDF]
Nature Chemical Biology, 2009 Protein degradation plays a central role in many cellular functions. Misfolded and damaged proteins are removed from the cell to avoid toxicity. The concentrations of regulatory proteins are adjusted by degradation at the appropriate time. Both foreign and native proteins are digested into small peptides as part of the adaptive immune response.
Erin K, Schrader +2 more
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