Results 1 to 10 of about 2,545,811 (118)

Ligands binding diffusively to protein target act as inhibitors of protein-protein interactions. [PDF]

PLoS Computational Biology
Nuclear localization signal (NLS) sequence from capsid protein of Venezuelan equine encephalitis virus (VEEV) binds to importin-α transport protein and clogs nuclear import. Prevention of viral NLS binding to importin-α may represent a viable therapeutic
William Jeffries, Bryan M Delfing, Xavier E Laracuente, Xingyu Luo, Audrey Olson, Kenneth W Foreman, Kyung Hyeon Lee, Greg Petruncio, Vito De Benedictis, Mikell Paige, Kylene Kehn-Hall, Christopher Lockhart, Dmitri K Klimov   +12 more
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AI-first structural identification of pathogenic protein target interfaces. [PDF]

PLoS Computational Biology
The risk of pandemics is increasing as global population growth and interconnectedness accelerate. Understanding the structural basis of protein-protein interactions between pathogens and hosts is critical for elucidating pathogenic mechanisms and ...
Mihkel Saluri, Michael Landreh, Patrick Bryant   +2 more
doaj   +2 more sources

Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus

Frontiers in Endocrinology, 2021
Type 2 diabetes Mellitus (T2DM) prevalence has significantly increased worldwide in recent years due to population age, obesity, and modern sedentary lifestyles. The projections estimate that 439 million people will be diabetic in 2030.
Karina Ramírez-Alarcón, Montserrat Victoriano, Lorena Mardones, Marcelo Villagran, Marcelo Villagran, Ahmed Al-Harrasi, Ahmed Al-Rawahi, Natália Cruz-Martins, Natália Cruz-Martins, Natália Cruz-Martins, Javad Sharifi-Rad, Javad Sharifi-Rad, Miquel Martorell, Miquel Martorell, Miquel Martorell   +14 more
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Chemodivergent assembly of ortho-functionalized phenols with tunable selectivity via rhodium(III)-catalyzed and solvent-controlled C-H activation

Communications Chemistry, 2021
Ortho functionalisation of phenols can be achieved using N-phenoxy amide directing groups. Here a method for chemodivergent C-H alkenylation, alkylation, carboetherification, or [3 + 2] annulation is presented, with product selectivity determined by the ...
Haiman Zhang, Shuang Lin, Hui Gao, Kaixin Zhang, Yi Wang, Zhi Zhou, Wei Yi   +6 more
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Amphiphilic Aminated Derivatives of [60]Fullerene as Potent Inhibitors of Tumor Growth and Metastasis

Advanced Science, 2022
Malignant proliferation and metastasis are the hallmarks of cancer cells. Aminated [70]fullerene exhibits notable antineoplastic effects, promoting it a candidate for multi‐targeted cancer drugs.
Jiawei Huo, Jie Li, Yang Liu, Libin Yang, Xinran Cao, Chong Zhao, Yicheng Lu, Wei Zhou, Shumu Li, Jianan Liu, Jiao Li, Xing Li, Jing Wan, Rui Wen, Mingming Zhen, Chunru Wang, Chunli Bai   +16 more
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MG1141A as a Highly Potent Monoclonal Neutralizing Antibody Against SARS-CoV-2 Variants

Frontiers in Immunology, 2021
Since the coronavirus disease outbreak in 2019, several antibody therapeutics have been developed to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Antibody therapeutics are effective in neutralizing the virus and reducing
Sua Lee, Shina Jang, Jihoon Kang, Soo Bin Park, Young Woo Han, Hyemi Nam, Munkyung Kim, Jeewon Lee, Ki Joon Cho, Jeonghun Kim, Miyoung Oh, Jihye Ryu, Jong Hyeon Seok, Yunhwa Kim, Jee-Boong Lee, Man-Seong Park, Yong-Sung Kim, Hosun Park, Dong-Sik Kim, Dong-Sik Kim   +19 more
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Structural basis for the broad and potent cross-reactivity of an N501Y-centric antibody against sarbecoviruses

Frontiers in Immunology, 2022
More than 80% of SARS-CoV-2 variants, including Alpha and Omicron, contain an N501Y mutation in the receptor-binding domain (RBD) of the spike protein. The N501Y change is an adaptive mutation enabling tighter interaction with the human ACE2 receptor. We
Bo-Seong Jeong, Joon Young Jeon, Chih-Jen Lai, Hye-Yeoung Yun, Jae U. Jung, Byung-Ha Oh, Byung-Ha Oh   +6 more
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TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away

Cell Reports, 2023
Summary: Tripartite motif-containing protein 21 (TRIM21) is a cytosolic antibody receptor and E3 ubiquitin ligase that promotes destruction of a broad range of pathogens.
Tycho E.T. Mevissen, Anisa V. Prasad, Johannes C. Walter   +2 more
doaj   +1 more source

Utilization of macrocyclic peptides to target protein-protein interactions in cancer

Frontiers in Oncology, 2022
Protein-protein interactions (PPIs) play vital roles in normal cellular processes. Dysregulated PPIs are involved in the process of various diseases, including cancer.
Jiawen Yang, Jiawen Yang, Jiawen Yang, Qiaoliang Zhu, Yifan Wu, Yifan Wu, Yifan Wu, Xiaojuan Qu, Xiaojuan Qu, Xiaojuan Qu, Haixia Liu, Haixia Liu, Haixia Liu, Biao Jiang, Biao Jiang, Di Ge, Xiaoling Song   +16 more
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Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains

Cell Reports, 2021
Summary: Non-degradative ubiquitin chains and phosphorylation events govern signaling responses by innate immune receptors. The deubiquitinase CYLD in complex with SPATA2 is recruited to receptor signaling complexes by the ubiquitin ligase LUBAC and ...
Paul R. Elliott, Derek Leske, Jane Wagstaff, Lisa Schlicher, Georgina Berridge, Sarah Maslen, Frederik Timmermann, Biao Ma, Roman Fischer, Stefan M.V. Freund, David Komander, Mads Gyrd-Hansen   +11 more
doaj   +1 more source