Results 11 to 20 of about 3,768,680 (342)
Ligands binding diffusively to protein target act as inhibitors of protein-protein interactions. [PDF]
PLoS Computational BiologyNuclear localization signal (NLS) sequence from capsid protein of Venezuelan equine encephalitis virus (VEEV) binds to importin-α transport protein and clogs nuclear import. Prevention of viral NLS binding to importin-α may represent a viable therapeutic
William Jeffries +12 more
doaj +2 more sources
AI-first structural identification of pathogenic protein target interfaces. [PDF]
PLoS Computational BiologyThe risk of pandemics is increasing as global population growth and interconnectedness accelerate. Understanding the structural basis of protein-protein interactions between pathogens and hosts is critical for elucidating pathogenic mechanisms and ...
Mihkel Saluri +2 more
doaj +2 more sources
Multiplexed in-gel microfluidic immunoassays: characterizing protein target loss during reprobing of benzophenone-modified hydrogels. [PDF]
Sci Rep, 2019 From whole tissues to single-cell lysate, heterogeneous immunoassays are widely utilized for analysis of protein targets in complex biospecimens. Recently, benzophenone-functionalized hydrogel scaffolds have been used to immobilize target protein for ...
Gopal A, Herr AE.
europepmc +4 more sources
Optimal TELSAM-Target Protein Linker Character is Target Protein-Dependent [PDF]
Structural DynamicsThe fusion of the sterile alpha motif domain of the human translocation ETS leukemia protein (TELSAM) to a protein of interest has been shown to significantly enhance crystallization propensity and improve diffraction quality.
Maria Jose P Romo +19 more
doaj +3 more sources
Exploration of Target Spaces in the Human Genome for Protein and Peptide Drugs
Genomics, Proteomics & Bioinformatics, 2022 After decades of development, protein and peptide drugs have now grown into a major drug class in the marketplace. Target identification and validation are crucial for the discovery of protein and peptide drugs, and bioinformatics prediction of targets ...
Zhongyang Liu +10 more
doaj +3 more sources
Deubiquitinase-targeting chimeras for targeted protein stabilization [PDF]
Nature Chemical Biology, 2022 Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These diseases would be therapeutically benefited by targeted protein stabilization (TPS). Here we present deubiquitinase-targeting chimeras (DUBTACs), heterobifunctional small molecules consisting of a deubiquitinase recruiter linked to a protein-targeting ligand, to ...
Nathaniel J. Henning +23 more
openaire +4 more sources
Communications Chemistry, 2021 Ortho functionalisation of phenols can be achieved using N-phenoxy amide directing groups. Here a method for chemodivergent C-H alkenylation, alkylation, carboetherification, or [3 + 2] annulation is presented, with product selectivity determined by the ...
Haiman Zhang +6 more
doaj +1 more source
Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus
Frontiers in Endocrinology, 2021 Type 2 diabetes Mellitus (T2DM) prevalence has significantly increased worldwide in recent years due to population age, obesity, and modern sedentary lifestyles. The projections estimate that 439 million people will be diabetic in 2030.
Karina Ramírez-Alarcón +14 more
doaj +1 more source
Advanced Science, 2022 Malignant proliferation and metastasis are the hallmarks of cancer cells. Aminated [70]fullerene exhibits notable antineoplastic effects, promoting it a candidate for multi‐targeted cancer drugs.
Jiawei Huo +16 more
doaj +1 more source
MG1141A as a Highly Potent Monoclonal Neutralizing Antibody Against SARS-CoV-2 Variants
Frontiers in Immunology, 2021 Since the coronavirus disease outbreak in 2019, several antibody therapeutics have been developed to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Antibody therapeutics are effective in neutralizing the virus and reducing
Sua Lee +19 more
doaj +1 more source