Results 11 to 20 of about 2,449,011 (263)
TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away
Cell Reports, 2023 Summary: Tripartite motif-containing protein 21 (TRIM21) is a cytosolic antibody receptor and E3 ubiquitin ligase that promotes destruction of a broad range of pathogens.
Tycho E.T. Mevissen +2 more
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Utilization of macrocyclic peptides to target protein-protein interactions in cancer
Frontiers in Oncology, 2022 Protein-protein interactions (PPIs) play vital roles in normal cellular processes. Dysregulated PPIs are involved in the process of various diseases, including cancer.
Jiawen Yang +16 more
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Targeting of proteins to mitochondria [PDF]
Biochemical Society Transactions, 2000 A clear picture has emerged over the past years on how a ‘classic’ mitochondrial protein, like subunit IV of cytochrome c oxidase, might be targeted to mitochondria. The targeting and subsequent import process involves the commitment of the TOM (ranslocase in the uter itochondrial membrane) receptor complex on the mitochondrial surface, a TIM ...
openaire +2 more sources
Modeling protein target search in human chromosomes
Physical Review Research, 2021 Several processes in the cell, such as gene regulation, start when key proteins recognize and bind to short DNA sequences. However, as these sequences can be hundreds of million times shorter than the genome, they are hard to find by simple diffusion ...
Markus Nyberg +3 more
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Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
Cell Reports, 2021 Summary: Non-degradative ubiquitin chains and phosphorylation events govern signaling responses by innate immune receptors. The deubiquitinase CYLD in complex with SPATA2 is recruited to receptor signaling complexes by the ubiquitin ligase LUBAC and ...
Paul R. Elliott +11 more
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PRODUCTION OF SARS-COV-2 MEMBRANE PROTEIN AS BETTER TARGET PROTEIN FOR DIAGNOSTIC APPLICATION
International Journal of Infectious Diseases, 2023 Intro: The COVID-19 pandemic is caused by the SARS-CoV-2 virus, an enveloped RNA of the coronavirus family. The advancement in molecular technology and biochemistry has accelerated the development of diagnostic reagents and assays.
N.A. Mat Rahim +7 more
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Molecular Biomedicine, 2023 Immunocompromised individuals are particularly vulnerable to viral infections and reactivation, especially endogenous herpes viruses such as Epstein-Barr virus (EBV), a member of oncogenic gamma-herpesviruses, which are commonly linked to pneumonia and ...
Aiping Qin +11 more
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BMC Bioinformatics, 2022 Background Target drugs play an important role in the clinical treatment of virus diseases. Virus-encoded proteins are widely used as targets for target drugs.
Shengrong Xia +7 more
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Transmembrane Protein TMEM230, a Target of Glioblastoma Therapy
Frontiers in Cellular Neuroscience, 2021 Glioblastomas (GBM) are the most aggressive tumors originating in the brain. Histopathologic features include circuitous, disorganized, and highly permeable blood vessels with intermittent blood flow.
Cinzia Cocola +32 more
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Protein Interactome of Amyloid-β as a Therapeutic Target
Pharmaceuticals, 2023 The amyloid concept of Alzheimer’s disease (AD) assumes the β-amyloid peptide (Aβ) as the main pathogenic factor, which injures neural and other brain cells, causing their malfunction and death.
Vladimir F. Lazarev +4 more
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