Results 11 to 20 of about 2,545,960 (263)

Optimal TELSAM-Target Protein Linker Character is Target Protein-Dependent [PDF]

Structural Dynamics
The fusion of the sterile alpha motif domain of the human translocation ETS leukemia protein (TELSAM) to a protein of interest has been shown to significantly enhance crystallization propensity and improve diffraction quality.
Maria Jose P Romo, Alihikaua Keliiliki, Jacob C Aerett, Joseph F Gonzalez, Ethan Noakes, Elijah W Wilson, Conrad Smith, Blake Averett, Dalton Hansen, Riley Nickles, Miles Bradford, Sara Soleimani, Tobin Smith, Supeshala Nawarathnage, Prasadika Samarwickrama, Ariel Kelsch, Derick Bunn, Cameron Stewart, Seth Brown, Tzanko I Doukov   +19 more
doaj   +3 more sources

Deubiquitinase-targeting chimeras for targeted protein stabilization [PDF]

Nature Chemical Biology, 2022
Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These diseases would be therapeutically benefited by targeted protein stabilization (TPS). Here we present deubiquitinase-targeting chimeras (DUBTACs), heterobifunctional small molecules consisting of a deubiquitinase recruiter linked to a protein-targeting ligand, to ...
Nathaniel J. Henning, Lydia Boike, Jessica N. Spradlin, Carl C. Ward, Gang Liu, Erika Zhang, Bridget P. Belcher, Scott M. Brittain, Matthew J. Hesse, Dustin Dovala, Lynn M. McGregor, Rachel Valdez Misiolek, Lindsey W. Plasschaert, David J. Rowlands, Feng Wang, Andreas O. Frank, Daniel Fuller, Abigail R. Estes, Katelyn L. Randal, Anoohya Panidapu, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Daniel K. Nomura   +23 more
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Targeting proteins for degradation [PDF]

Nature Chemical Biology, 2009
Protein degradation plays a central role in many cellular functions. Misfolded and damaged proteins are removed from the cell to avoid toxicity. The concentrations of regulatory proteins are adjusted by degradation at the appropriate time. Both foreign and native proteins are digested into small peptides as part of the adaptive immune response.
Erin K, Schrader, Kristine G, Harstad, Andreas, Matouschek   +2 more
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Targeting of proteins to mitochondria [PDF]

Biochemical Society Transactions, 2000
A clear picture has emerged over the past years on how a ‘classic’ mitochondrial protein, like subunit IV of cytochrome c oxidase, might be targeted to mitochondria. The targeting and subsequent import process involves the commitment of the TOM (ranslocase in the uter itochondrial membrane) receptor complex on the mitochondrial surface, a TIM ...
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Modeling protein target search in human chromosomes

Physical Review Research, 2021
Several processes in the cell, such as gene regulation, start when key proteins recognize and bind to short DNA sequences. However, as these sequences can be hundreds of million times shorter than the genome, they are hard to find by simple diffusion ...
Markus Nyberg, Tobias Ambjörnsson, Per Stenberg, Ludvig Lizana   +3 more
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PRODUCTION OF SARS-COV-2 MEMBRANE PROTEIN AS BETTER TARGET PROTEIN FOR DIAGNOSTIC APPLICATION

International Journal of Infectious Diseases, 2023
Intro: The COVID-19 pandemic is caused by the SARS-CoV-2 virus, an enveloped RNA of the coronavirus family. The advancement in molecular technology and biochemistry has accelerated the development of diagnostic reagents and assays.
N.A. Mat Rahim, J. Zahidi, N.A. Amir Hashim, N.A. Nor Amdan, H.F. Zamri, M.R. Mohd Ali, R. Mohd Zain, N. Ahmad   +7 more
doaj   +1 more source

hMSCs treatment attenuates murine herpesvirus-68 (MHV-68) pneumonia through altering innate immune response via ROS/NLRP3 signaling pathway

Molecular Biomedicine, 2023
Immunocompromised individuals are particularly vulnerable to viral infections and reactivation, especially endogenous herpes viruses such as Epstein-Barr virus (EBV), a member of oncogenic gamma-herpesviruses, which are commonly linked to pneumonia and ...
Aiping Qin, Xiao-juan Wang, Jijun Fu, Ao Shen, Xiaotao Huang, Zhida Chen, Huiting Wu, Yu Jiang, Qian Wang, Fei Chen, Andy Peng Xiang, Xiyong Yu   +11 more
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Transmembrane Protein TMEM230, a Target of Glioblastoma Therapy

Frontiers in Cellular Neuroscience, 2021
Glioblastomas (GBM) are the most aggressive tumors originating in the brain. Histopathologic features include circuitous, disorganized, and highly permeable blood vessels with intermittent blood flow.
Cinzia Cocola, Cinzia Cocola, Valerio Magnaghi, Edoardo Abeni, Paride Pelucchi, Valentina Martino, Laura Vilardo, Eleonora Piscitelli, Arianna Consiglio, Giorgio Grillo, Ettore Mosca, Roberta Gualtierotti, Daniela Mazzaccaro, Gina La Sala, Chiara Di Pietro, Mira Palizban, Sabino Liuni, Giuseppina DePedro, Stefano Morara, Giovanni Nano, Giovanni Nano, James Kehler, Burkhard Greve, Alessio Noghero, Alessio Noghero, Daniela Marazziti, Federico Bussolino, Federico Bussolino, Gianfranco Bellipanni, Igea D’Agnano, Martin Götte, Ileana Zucchi, Rolland Reinbold   +32 more
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Targeting of proteins to the Golgi apparatus [PDF]

Glycoconjugate Journal, 1994
The Golgi apparatus maintains a highly organized structure in spite of the intense membrane traffic which flows into and out of this organelle. Resident Golgi proteins must have localization signals to ensure that they are targeted to the correct Golgi compartment and not swept further along the secretory pathway.
Gleeson, PA, Teasdale, RD, Burke, J
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Protein Interactome of Amyloid-β as a Therapeutic Target

Pharmaceuticals, 2023
The amyloid concept of Alzheimer’s disease (AD) assumes the β-amyloid peptide (Aβ) as the main pathogenic factor, which injures neural and other brain cells, causing their malfunction and death.
Vladimir F. Lazarev, Elizaveta A. Dutysheva, Igor E. Kanunikov, Irina V. Guzhova, Boris A. Margulis   +4 more
doaj   +1 more source