Recent Progress of Protein Tertiary Structure Prediction [PDF]
MoleculesThe prediction of three-dimensional (3D) protein structure from amino acid sequences has stood as a significant challenge in computational and structural bioinformatics for decades.
Qiqige Wuyun +7 more
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Improving AlphaFold2-based protein tertiary structure prediction with MULTICOM in CASP15 [PDF]
Communications Chemistry, 2023 Since the 14th Critical Assessment of Techniques for Protein Structure Prediction (CASP14), AlphaFold2 has become the standard method for protein tertiary structure prediction. One remaining challenge is to further improve its prediction.
Jian Liu +5 more
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Prediction of Protein Tertiary Structure via Regularized Template Classification Techniques [PDF]
Molecules, 2020 We discuss the use of the regularized linear discriminant analysis (LDA) as a model reduction technique combined with particle swarm optimization (PSO) in protein tertiary structure prediction, followed by structure refinement based on singular value ...
Óscar Álvarez-Machancoses +2 more
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Generative Adversarial Learning of Protein Tertiary Structures [PDF]
Molecules, 2021 Protein molecules are inherently dynamic and modulate their interactions with different molecular partners by accessing different tertiary structures under physiological conditions. Elucidating such structures remains challenging.
Taseef Rahman +3 more
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A hybrid variational autoencoder and WGAN with gradient penalty for tertiary protein structure generation [PDF]
Scientific ReportsElucidating the tertiary structure of proteins is important for understanding their functions and interactions. While deep neural networks have advanced the prediction of a protein’s native structure from its amino acid sequence, the focus on a single ...
Aalaa I. Sehsah +2 more
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Protein Tertiary Structure by Crosslinking/Mass Spectrometry. [PDF]
Trends Biochem Sci, 2018 Observing the structures of proteins within the cell and tracking structural changes under different cellular conditions are the ultimate challenges for structural biology. This, however, requires an experimental technique that can generate sufficient data for structure determination and is applicable in the native environment of proteins. Crosslinking/
Schneider M, Belsom A, Rappsilber J.
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A protein tertiary structure mimetic modulator of the Hippo signalling pathway [PDF]
Nature Communications, 2020 Targeting the interaction between transcription factor TEAD and its co-repressor VGL4 is an attractive strategy to chemically modulate Hippo signaling.
Hélène Adihou +21 more
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Advances in protein tertiary structure prediction
Biomedical and Biotechnology Research Journal, 2018 Proteins are composed of linear chains of amino acids that form a unique three-dimensional structure in their native environment. Such native structure favors the proteins to perform their biochemical activity.
Tayebeh Farhadi
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Protein tertiary structure and the myoglobin phase diagram. [PDF]
Sci Rep, 2019 AbstractWe develop an effective theory approach to investigate the phase properties of globular proteins. Instead of interactions between individual atoms or localized interaction centers, the approach builds directly on the tertiary structure of a protein. As an example we construct the phase diagram of (apo)myoglobin with temperature (T) and acidity (
Begun A, Molochkov A, Niemi AJ.
europepmc +4 more sources
Design and Synthesis of Crosslinked Helix Dimers as Protein Tertiary Structure Mimics. [PDF]
Curr Protoc, 2022 Hong SH, Nguyen T, Arora P.
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