Results 91 to 100 of about 166,818 (301)

Front Cover: Protein Backbone Alteration in Non‐Hairpin β‐Turns: Impacts on Tertiary Folded Structure and Folded Stability (ChemBioChem 11/2023) [PDF]

, 2023
Thomas W. Harmon, W. Seth Horne
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Protein tertiary structure prediction and refinement using deep learning and Rosetta in CASP14. [PDF]

Proteins, 2021
Anishchenko I, Baek M, Park H, Hiranuma N, Kim DE, Dauparas J, Mansoor S, Humphreys IR, Baker D.   +8 more
europepmc   +1 more source

Using neural networks and evolutionary information in decoy discrimination for protein tertiary structure prediction [PDF]

, 2008
Ching-Wai Tan, David T. Jones
openalex   +1 more source

Prediction of Protein Tertiary Structure Using Genetic Algorithm

International Journal of Electronics Signals and Systems, 2011
Proteins are essential for the biological processes in the human body. They can only perform their functions when they fold into their tertiary structure .Protein structure can be determined experimentally and computationally. Experimental methods are time consuming and high-priced and it is not always feasible to identify the protein structure ...
G. Sindhu, S. Sudha
openaire   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Decision letter for "Protein tertiary structure prediction and refinement using deep learning and Rosetta in CASP14"

, 2021

openalex   +2 more sources

'Never Mind a Barrel'

CHIMIA, 2001
The general usefulness of rigid-rod molecules rather than ?-sheets as molecular staves for the construction of artificial ?-barrels with preserved structural and functional plasticity is described.
Bodo Baumeister, Gopal Das, Naomi Sakai, Stefan Matile   +3 more
doaj  

Ancient gene duplications in RNA viruses revealed by protein tertiary structure comparisons. [PDF]

Virus Evol, 2021
Cisneros-Martínez AM, Becerra A, Lazcano A.   +2 more
europepmc   +1 more source