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Computational Methods for Protein Tertiary Structure Analysis
2023Protein folding accuracy is fundamental to all cells. In spite of this, it is difficult to maintain the fidelity of protein synthesis and folding due to the fact that the implicit genetic and biochemical systems are inherently prone to error, which leads to the constant production of a certain amount of misfolded proteins.
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New Programs for Protein Tertiary Structure Prediction
Nature Biotechnology, 1993Prediction of protein tertiary structure remains an unsolved problem in molecular biology, but a solution to this problem is extremely important for protein engineering and rational drug design. Recent developments in motif recognition and side chain modeling present the prospect of nearly automatic model building for a large fraction of newly ...
J S, Fetrow, S H, Bryant
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Protein denaturation and tertiary structure
Journal of Chemical Education, 1986Students may dutifully learn the concepts of protein structure, but meaning is often abstracted due to the lack of opportunity for observing the physical entity. To bridge this gap, an inexpensive denaturation experiment is designed to demonstrate the presence of tertiary structure.
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The MULTICOM Protein Tertiary Structure Prediction System
2013With the expansion of genomics and proteomics data aided by the rapid progress of next-generation sequencing technologies, computational prediction of protein three-dimensional structure is an essential part of modern structural genomics initiatives. Prediction of protein structure through understanding of the theories behind protein sequence-structure
Jilong, Li +6 more
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Efficient Approaches for Retrieving Protein Tertiary Structures
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2012The 3D conformation of a protein in the space is the main factor which determines its function in living organisms. Due to the huge amount of newly discovered proteins, there is a need for fast and accurate computational methods for retrieving protein structures.
Georgina, Mirceva +3 more
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Does secondary structure determine tertiary structure in proteins?
Proteins: Structure, Function, and Bioinformatics, 2005AbstractIs highly approximate knowledge of a protein's backbone structure sufficient to successfully identify its family, superfamily, and tertiary fold? To explore this question, backbone dihedral angles were extracted from the known three‐dimensional structure of 2,439 proteins and mapped into 36 labeled, 60° × 60° bins, called mesostates. Using this
Haipeng, Gong, George D, Rose
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Protein Tertiary Structure Prediction
2006One of the most important scientific achievements of the twentieth century was the discovery of the DNA double helical structure by Watson and Crick in 1953. Strictly speaking, the work was the result of a three-dimensional modeling conducted partly based on data obtained from x-ray diffraction of DNA and partly based on chemical bonding information ...
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Tertiary Structure of Proteins
2010In Chapter 4, we gave a brief introduction to proteins. The structures of a very large number of proteins have been determined and it is possible to ask fundamental questions: Given the primary sequence, what is tertiary structure? How does the protein fold into the final structure? This “folding problem” has attracted a great deal of attention, and it
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Describing patterns of protein tertiary structure
1985Publisher Summary This chapter discusses the four major categories of tertiary structure within which subtypes that are more specific described: (1) antiparallel a, (2) parallel α/β, (3) antiparallel β, and (4) small irregular proteins. Within this first major category, the simplest type of structure is the up-and-down helix bundle: an approximate ...
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From Ramachandran Maps to Tertiary Structures of Proteins
The Journal of Physical Chemistry B, 2015Sequence to structure of proteins is an unsolved problem. A possible coarse grained resolution to this entails specification of all the torsional (Φ, Ψ) angles along the backbone of the polypeptide chain. The Ramachandran map quite elegantly depicts the allowed conformational (Φ, Ψ) space of proteins which is still very large for the purposes of ...
Debarati, DasGupta +2 more
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