Results 51 to 60 of about 166,818 (301)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

PS4: a next-generation dataset for protein single-sequence secondary structure prediction

BioTechniques, 2023
Protein secondary structure prediction is a subproblem of protein folding. A light-weight algorithm capable of accurately predicting secondary structure from only the protein residue sequence could provide useful input for tertiary structure prediction ...
Omar Peracha
doaj   +1 more source

Tertiary Structure of Uracil-DNA Glycosylase Inhibitor Protein [PDF]

Journal of Biological Chemistry, 1995
The Bacillus subtilis bacteriophage PBS2 uracil-DNA glycosylase inhibitor (Ugi) is an acidic protein of 84 amino acids that inactivates uracil-DNA glycosylase from diverse organisms. The secondary structure of Ugi consists of five anti-parallel beta-strands and two alpha-helices (Balasubramanian, S., Beger, R.D., Bennett, S.E., Mosbaugh, D.W., and ...
R D, Beger, S, Balasubramanian, S E, Bennett, D W, Mosbaugh, P H, Bolton   +4 more
openaire   +2 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

IN SILICO CHARACTERIZATION OF HUMAN INTERFERON ALPHA/BETA RECEPTOR 2 (ISOFORM A, B AND C) PROTEIN

Pakistan Armed Forces Medical Journal, 2021
Objective: To predict the tertiary structure of human interferon alpha/beta receptor 2 protein. Study Design: Structure prediction by using bio informatics tools. Place and Duration of Study: Department of Biochemistry, Swat Medical College (STMC),
Ambreen Javed, Gulshan Ara Trali, Hassan Burair Abbas, Alia Sadiq   +3 more
doaj  

In silico characterization and structural modeling of bacterial metalloprotease of family M4

Journal of Genetic Engineering and Biotechnology, 2021
Background The M4 family of metalloproteases is comprised of a large number of zinc-containing metalloproteases. A large number of these enzymes are important virulence factors of pathogenic bacteria and therefore potential drug targets.
Rajnee Hasan, Md. Nazmul Haq Rony, Rasel Ahmed   +2 more
doaj   +1 more source

Tertiary alphabet for the observable protein structural universe [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Proteins fold into intricate 3D structures, determined by their amino acid sequences. Different proteins can fold into drastically different structures, and the space of all possible structures appears hopelessly complex.
Craig O, Mackenzie, Jianfu, Zhou, Gevorg, Grigoryan   +2 more
openaire   +2 more sources

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Finding protein sites using machine learning methods

Ingeniería e Investigación, 2003
The increasing amount of protein three-dimensional (3D) structures determined by x-ray and NMR technologies as well as structures predicted by computational methods results in the need for automated methods to provide inital annotations.
Jaime Leonardo Bobadilla Molina, Fernando Niño, Tobías Mojica   +2 more
doaj  

A triphosphate tunnel metalloenzyme from pear (PbrTTM1) moonlights as an adenylate cyclase

Frontiers in Plant Science, 2023
Adenylyl cyclase (AC) is the vital enzyme for generating 3′,5′-cyclic adenosine monophosphate, an important signaling molecule with profound nutritional and medicinal values.
Ye Yuan, Yuye Liu, Shuangjiang Chen, Lili Wang, Lili Wang, Lixin Wang, Lixin Wang, Yahong Niu, Xin Zhao, Zhihui Zhao, Zhihui Zhao, Zhiguo Liu, Zhiguo Liu, Mengjun Liu, Mengjun Liu   +14 more
doaj   +1 more source