Results 151 to 160 of about 1,760,654 (353)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

An AIEgen-Based Carrier Enables Efficient Cytosolic Delivery of Bioactive Proteins

International Journal of Nanomedicine
Yu Yang,1– 3,* Huixia Jia,1– 3,* Lin Yang,4 Benzhao He,4 Ke Zhang,1– 3 He Liu1– 3 1Department of Systems Science, Faculty of Arts and Sciences, Beijing Normal University, Zhuhai, Guangdong, 519087, People’s Republic of China ...
Yang Y, Jia H, Yang L, He B, Zhang K, Liu H   +5 more
doaj  

Exploring the K+ binding site and its coupling to transport in the neurotransmitter:sodium symporter LeuT

eLife
The neurotransmitter:sodium symporters (NSSs) are secondary active transporters that couple the reuptake of substrate to the symport of one or two sodium ions. One bound Na+ (Na1) contributes to the substrate binding, while the other Na+ (Na2) is thought
Solveig G Schmidt, Andreas Nygaard, Joseph A Mindell, Claus J Loland   +3 more
doaj   +1 more source

A real-time analysis of protein transport via the twin arginine translocation pathway in response to different components of the protonmotive force. [PDF]

J Biol Chem, 2023
Zhou W, Hao B, Bricker TM, Theg SM.
europepmc   +1 more source

Antibody-Mediated Modification of the Binding Properties of a Protein Related to Galactose Transport [PDF]

, 1972
Boris Rotman, John Ellis
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The role of motor proteins in photoreceptor protein transport and visual function. [PDF]

Ophthalmic Genet, 2022
Radhakrishnan R, Dronamraju VR, Leung M, Gruesen A, Solanki AK, Walterhouse S, Roehrich H, Song G, da Costa Monsanto R, Cureoglu S, Martin R, Kondkar AA, van Kuijk FJ, Montezuma SR, Knöelker HJ, Hufnagel RB, Lobo GP.   +16 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Evidence for RNA or protein transport from somatic tissues to the male reproductive tract in mouse. [PDF]

Elife, 2023
Rinaldi V, Messemer K, Desevin K, Sun F, Berry BC, Kukreja S, Tapper AR, Wagers AJ, Rando OJ.   +8 more
europepmc   +1 more source

Review for "Ebola virus protein VP40 binding to Sec24c for transport to the plasma membrane"

, 2021

openalex   +1 more source