Results 161 to 170 of about 6,396,996 (306)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The role of industrial design in addressing the disparity between user perceptions of public and private transport

, 2007
This paper examines the disparity between the perceptions of private and public transport from those who might exercise choice between them. There is a great body of literature concerning the identification of problems in public transport mobility.
Coxon, Selby, Napper, Robbie, Allen, Jonathon (R13609)   +2 more
core  

Live-cell Imaging of Biosynthetic Protein Transport in Hepatocytes. [PDF]

Methods Mol Biol, 2022
Lázaro-Diéguez F, Müsch A.
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

GPNMB promotes double-membrane vesicle accumulation and facilitates structural protein transport during PEDV infection. [PDF]

Virulence
Li Q, Wei Q, Wang A, Lu Y, Zhang S, Feng H, Wang F, Sun X, Xing G, Liu Y, Bai Y, Jiao W, Zhang G.   +12 more
europepmc   +1 more source

Interactions between TULP3 tubby domain and ARL13B amphipathic helix promote lipidated protein transport to cilia. [PDF]

Mol Biol Cell, 2023
Palicharla VR, Hwang SH, Somatilaka BN, Legué E, Shimada IS, Familiari NE, Tran VM, Woodruff JB, Liem KF, Mukhopadhyay S.   +9 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Impact of Microgravity on Cytoskeletal Dynamics, Protein Transport, and Signaling Networks: Potential Therapeutic Opportunities for Skin Health. [PDF]

Int J Mol Sci
Ballard JM, Chiguru R, Deeb MB, Swatsburg RB, Lau AY, Davis GH, Demiri M, Keller JT, Nourachi B, Abu Shihadeh TA, Schneider R, Articulo E, Daye NM, Awwad TA, Lamko B, Bailey SM, Guerra BL, Guerra SL, Quarterman C, Nanjundan M.   +19 more
europepmc   +1 more source

Ubiquitin-conjugating activity by PEX4 is required for efficient protein transport to peroxisomes in Arabidopsis thaliana. [PDF]

J Biol Chem, 2022
Mano S, Hayashi Y, Hikino K, Otomo M, Kanai M, Nishimura M.   +5 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source