Results 161 to 170 of about 1,744,161 (299)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

A shared mechanism for Bacteroidota protein transport and gliding motility. [PDF]

Nat Commun
Liu X, Avramova M, Deme JC, Jones RL, Lundgren CAK, Lea SM, Berks BC.   +6 more
europepmc   +1 more source

Aging power spectrum of membrane protein transport and other subordinated random walks. [PDF]

Nat Commun, 2021
Fox ZR, Barkai E, Krapf D.
europepmc   +1 more source

Bioenergetics of protein transport into mitochondria [PDF]

, 1988
Döhren, H. von, Jaenicke, L., Kleinkauf, Horst, Neupert, Walter, Pfanner, Nikolaus   +4 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Protein Transport [PDF]

, 2008
openaire   +2 more sources

The role of phase separation for RNA and protein transport through the nuclear pore complex. [PDF]

J Exp Bot
Ejike JO, Davis GV, Restrepo-Escobar A, Dalal A, Nakamura M, Frommer WB, Schladt TM.   +6 more
europepmc   +1 more source

Structural characterization of protein transport by the Type 9 Secretion System

, 2023
Berks B, Lauber F, Deme J, Liu X, Kjær A, Miller H, Alcock F, Lea S.   +7 more
europepmc   +1 more source

Protein Transport through Nanopores Illuminated by Long-Time-Scale Simulations. [PDF]

ACS Nano, 2021
Mitscha-Baude G, Stadlbauer B, Howorka S, Heitzinger C.   +3 more
europepmc   +1 more source