Results 181 to 190 of about 6,396,996 (306)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Transmembrane transporter proteins: Capturing transport in motion

open access: yesBasic & Clinical Pharmacology & Toxicology, 2023
Loland, Claus J.   +3 more
openaire   +3 more sources

The role of phase separation for RNA and protein transport through the nuclear pore complex. [PDF]

open access: yesJ Exp Bot
Ejike JO   +6 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Multimodal Freight Transport Planning: A Toolbox Supporting Stakeholders’ Collaboration

open access: yes, 2019
This paper aims to analyse the planning of chemical transports’ shift from road to the more complex multimodal freight transport, and presents a toolbox developed to support the stakeholders in the process.
Cichosz, Marzenna; SGH Warsaw School of Economics, Department of Transport
core  

Structural characterization of protein transport by the Type 9 Secretion System

open access: yes, 2023
Berks B   +7 more
europepmc   +1 more source

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