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Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source
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Transport of proteins into chloroplasts

Photosynthesis Research, 1988
The import of cytoplasmically synthesized proteins into chloroplasts involves an interaction between at least two components; the precursor protein, and the import apparatus in the chloroplast envelope membrane. This review summarizes the information available about each of these components.
Thomas H. Lubben   +2 more
openaire   +3 more sources

Transport of Proteins into Mitochondria

The Protein Journal, 2019
Mitochondria are essential organelles of eukaryotic cells. They consist of hundreds of different proteins that exhibit crucial activities in respiration, catabolic metabolism and the synthesis of amino acids, lipids, heme and iron-sulfur clusters.
Katja G. Hansen, Johannes M. Herrmann
openaire   +3 more sources

Membrane Transport of Proteins

Nature New Biology, 1972
FACILITATED diffusion of small organic molecules across cell membranes is thought to be carrier-mediated in part because the process displays reaction kinetics. Models describing carrier transport assume that the transported molecule is associated with the membrane, reacting presumably with membrane proteins, and is then moved across the barrier.
Stephen S. Rothman, C. Liebow
openaire   +3 more sources

Protein Transport into Chloroplasts

Annual Review of Plant Biology, 2010
Most proteins in chloroplasts are encoded by the nuclear genome and synthesized as precursors with N-terminal targeting signals called transit peptides. Novel machinery has evolved to specifically import these proteins from the cytosol into chloroplasts.
Hsou-min Li, Chi Chou Chiu
openaire   +3 more sources

Zinc Transporter Proteins

Neurochemical Research, 2017
Zinc, which is involved in the structure of all enzyme classes, is a micro nutrient element and necessary for growth and development. The ability of zinc to function without causing toxic effects is depends on the protection of its homeostasis. Zinc transporter proteins are responsible for keeping zinc at certain concentrations.
Abdulkerim Kasim Baltaci, Kemal Yuce
openaire   +2 more sources

Transport Proteins

Science Signaling, 2013
Animated lessons describe the classes of transport proteins and illustrate mechanisms of transport.
openaire   +2 more sources

Water-Transporting Proteins

Journal of Membrane Biology, 2009
Transport through lipids and aquaporins is osmotic and entirely driven by the difference in osmotic pressure. Water transport in cotransporters and uniporters is different: Water can be cotransported, energized by coupling to the substrate flux by a mechanism closely associated with protein.
openaire   +4 more sources

THE TRANSPORT OF PROTEINS INTO CHLOROPLASTS

Annual Review of Biochemistry, 1986
PERSPECTIVES AND SUMMARy . . . . . . .... . . .. .... 879 OVERVIEW OF TRANSPORT OF PROTEINS THROUGH MEMBRANES 880 Cotranslational Transport 880 Postt ranslational Transport 881 CHLOROPLAST TOPOLOGY: DIVERGENT PATHWAYS FOR PROTEIN IMPORT AND SORTING 882 Proteins of the Stromal Compartment 882 Transit Sequences of Stromal Protein Precursors ...
Gregory W. Schmidt, Michael L. Mishkind
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Bicarbonate transport proteins

Biochemistry and Cell Biology, 2002
Bicarbonate is not freely permeable to membranes. Yet, bicarbonate must be moved across membranes, as part of CO2metabolism and to regulate cell pH. Mammalian cells ubiquitously express bicarbonate transport proteins to facilitate the transmembrane bicarbonate flux.
Joseph R. Casey, Deborah Sterling
openaire   +3 more sources

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