Results 271 to 280 of about 8,970,337 (403)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

TFG regulates inner COPII coat recruitment to facilitate anterograde secretory protein transport. [PDF]

Mol Biol Cell
Kasberg W, Luong P, Minushkin K, Pustova I, Swift KA, Zhao M, Audhya A.   +6 more
europepmc   +1 more source

Reconstitution of D-glucose transport catalyzed by a protein fraction from human erythrocytes in sonicated liposomes.

, 1976
Masahiro Kasahara, Peter C. Hinkle
openalex   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Directing traffic: Chaperone-mediated protein transport in malaria parasites. [PDF]

Cell Microbiol, 2020
Florentin A, Cobb DW, Kudyba HM, Muralidharan V.   +3 more
europepmc   +1 more source

Selektive Wirkungen von Lindan (γ-1,2,3,4,5,6-Hexachlorcyclohexan) auf Photosynthese, Aminosäure — Membrantransport und Proteinsynthese bei Anacystis nidulans / Selective Effects of Lindane (γ-1,2,3,4,5,6 Hexachlorocyclohexane) on Photosynthesis, Membrane Transport of Amino Acids and Protein Synthesis in Anacystis nidulans [PDF]

, 1979
W. Simonis, Johanna Lee-Kaden
openalex   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Primary extranodal diffuse large B‐cell lymphoma: Molecular features, treatment, and prognosis

Aging and Cancer, Volume 3, Issue 3-4, Page 133-146, September-December 2022., 2022
One‐third of DLBCL arises from extranodal organs and is challenging to manage. Molecular features are critical to elucidate the differences in clinical features, predict the disease prognosis, and improve effective targeted therapeutic strategies. Abstract Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin's lymphoma and ...
Si‐Yuan Chen, Meng‐Meng Ji, Peng‐Peng Xu, Wei‐Li Zhao   +3 more
wiley   +1 more source

The role of chloroplast SRP54 domains and its C-terminal tail region in post- and co-translational protein transport in vivo. [PDF]

J Exp Bot
Bischoff A, Ortelt J, Dünschede B, Zegarra V, Bedrunka P, Bange G, Schünemann D.   +6 more
europepmc   +1 more source

IFT-A Structure Reveals Carriages for Membrane Protein Transport into Cilia

, 2022
Hesketh SJ, Mukhopadhyay AG, Nakamura D, Toropova K, Roberts AJ.   +4 more
europepmc   +1 more source