Protein tyrosine phosphatase, non-receptor type 2

Results 151 to 160 of about 105,512 (249)

Type I interferon overactivation in sera of patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease

Rheumatology &Autoimmunity, EarlyView.
Sera from patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease (ILD) exhibit significantly higher type I interferon (IFN‐I) bioactivity and interferon‐stimulated gene‐inducing activity compared to anti‐ARS‐positive ILD and healthy controls.
Shohei Nakamura +3 more
wiley +1 more source

Phosphatase Signaling as a Therapeutic Strategy in Schizophrenia. [PDF]

Int J Mol Sci
Molony LE, Tautz L.
europepmc +1 more source

Identification and Discrimination of Sulfated and Unsulfated Gut‐Hormone Biomarkers in Human Serum by Nanopore

Small, EarlyView.
This study discriminates between sulfated and unsulfated cholecystokinin‐8 gut‐hormone forms at single‐molecule‐level resolution. Using an aerolysin nanopore embedded in a hybrid lipid‐polymer membrane, the system produces distinct electrical signatures enabling highly sensitive detection, even in 20% human serum.
Luca Iesu +3 more
wiley +1 more source

The dual-specificity phosphatase JSP1 regulates neutrophil adhesion via integrin-SRC signaling in vascular inflammation. [PDF]

J Biol Chem
Li L, Tonks NK.
europepmc +1 more source

Integrin α2 (VLA-2; CD49B); notch homolog 1 translocation-associated (NOTCH1); protein tyrosine phosphatase non-receptor type 22 (PTPN22; LYP) [PDF]

Science-Business eXchange, 2010
openaire +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou +4 more
wiley +1 more source

Non-receptor tyrosine kinase signaling pathways and therapeutic implications. [PDF]

Signal Transduct Target Ther
Hossain MDA +4 more
europepmc +1 more source

Topic classification of synchrotron experiment proposals using the OpenAlex model: enhancing metadata granularity and assessing live service feasibility

Journal of Synchrotron Radiation, EarlyView.
This paper validates the OpenAlex model for real‐time topic classification of synchrotron proposals. The proposed live service architecture incorporates user verification, providing a scalable solution for introducing enhanced topic metadata into scientific workflows without sacrificing precision.Experiment proposals at synchrotron facilities serve as ...
Terence Tan +22 more
wiley +1 more source

Genetic role in autoimmune encephalitis and paraneoplastic neurological syndromes. [PDF]

Curr Opin Neurol
Binks SNM, Yip J, Knight JC.
europepmc +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source

ptpn2
female
medicine

animals
male
phosphorylation

polymorphism, single nucleotide
mice
genetic predisposition to disease