Results 1 to 10 of about 3,009 (161)

A Novel PTPN2 Isoform Differentially Regulates Immune Response. [PDF]

Eur J Immunol
ABSTRACT Genome‐wide association studies implicate the PTPN2 gene locus (18p11.21) in risk for several autoimmune diseases, including inflammatory bowel disease. Through genetic fine mapping, we identified the single‐nucleotide polymorphism rs80262450 in the PTPN2 gene as the putative causal variant.
Li X, Rahimov F, Wang R, Gao L, Ma R, Han T, Bi Y, Cruz F, Wang J, Grosskurth S, Asque E, Paez-Cortez J, Levesque MC, Crosbie NE, Radstake T, Biswas A, Katlinski K.   +16 more
europepmc   +3 more sources

Immune checkpoint PTPN2 predicts prognosis and immunotherapy response in human cancers

Heliyon, 2023
Background: PTPN2, a member of the non-receptor protein tyrosine phosphatases family, holds a crucial role in tumorigenesis and cancer immunotherapy. However, most studies on the role of PTPN2 in cancer are limited to specific cancer types.
Yongshuo Liu
exaly   +5 more sources

PTPN2 Negatively Regulates Macrophage Immune Responses and Cellular Bioenergetics [PDF]

FASEB Journal
ABSTRACT PTPN2 is encoded by the protein tyrosine phosphatase N2 (also known as TC‐PTP) and is a negative regulator of cytokine signaling and macrophage differentiation. In the past decade, our work and others, including several pharmaceuticals, have emphasized that inhibition of PTPN2 and PTPN1 (also known as PTP1B) may act as a new ...
Michel L Tremblay, Valerie Vinette
exaly   +4 more sources

Case report: JAK inhibitor treatment of immune dysregulation symptoms in a patient with PTPN2 deficiency [PDF]

Frontiers in Immunology
A heterozygous mutation in the PTPN2 gene has recently been described in several patients exhibiting symptoms of immune dysregulation. The gene encodes a ubiquitous non-receptor T-cell protein tyrosine phosphatase that exerts a negative feedback on the ...
Karaulov Alexander, Raykina Elena
exaly   +4 more sources

PTPN2 in the Immunity and Tumor Immunotherapy: A Concise Review

International Journal of Molecular Sciences, 2022
PTPN2 (protein tyrosine phosphatase non-receptor 2), also called TCPTP (T cell protein tyrosine phosphatase), is a member of the PTP family signaling proteins. Phosphotyrosine-based signaling of this non-transmembrane protein is essential for regulating cell growth, development, differentiation, survival, and migration.
Na Luo, Jiaping Tang, Luo Na
exaly   +3 more sources

PTPN2 deficiency amplifies inflammatory signalling and impairs functional maturation of human stem cell-derived islets [PDF]

Stem Cell Research & Therapy
Background Protein tyrosine phosphatases (PTPs) play key roles in β-cell function and diabetes development. PTPN2 is a candidate gene for type 1 diabetes (T1D) that negatively regulates JAK/STAT signalling.
Valerie Vandenbempt, Javier Negueruela, Francisco Ribeiro-Costa, Mariana Nunes, Leonardo Traini, Sema Elif Eski, Wadsen St-Pierre-Wijckmans, Stéphane Demine, Nicolas Baeyens, Hazem Ibrahim, Luciano G. Martelotto, Sumeet Pal Singh, Alessandra K. Cardozo, Mayank Bansal, Esteban N. Gurzov   +14 more
doaj   +2 more sources

The PTPN2 rs1893217 IBD risk allele increases susceptibility to AIEC invasion by a JAK-STAT-CEACAM6 axis [PDF]

Gut Microbes
Inflammatory bowel disease (IBD) patients often exhibit expansion of the gut pathobiont, adherent-invasive E. coli (AIEC). Loss of activity of the IBD susceptibility gene, protein tyrosine phosphatase type 2 (PTPN2), causes gut microbiota dysbiosis in ...
Pritha Chatterjee, Vinicius Canale, Stephanie J. King, Ali Shawki, Hillmin Lei, Alina N. Santos, Michael Haddad, Casey Gries, Dermot P. B. McGovern, James Borneman, Declan F. McCole   +10 more
doaj   +2 more sources

Intestinal epithelial PTPN2 limits pathobiont colonization by immune-directed antimicrobial responses [PDF]

Gut Microbes
Loss of activity of the inflammatory bowel disease (IBD) susceptibility gene, protein tyrosine phosphatase non-receptor type 2 (PTPN2), is associated with altered microbiome composition in both human subjects and mice.
Pritha Chatterjee, Marianne R. Spalinger, Charly Acevedo, Alina N. Santos, Casey M. Gries, Salomon M. Manz, Vinicius Canale, Ali Shawki, Anica Sayoc-Becerra, Hillmin Lei, Meli’sa S. Crawford, Lars Eckmann, James Borneman, Declan F. McCole   +13 more
doaj   +2 more sources

PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in MiceSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: Loss-of-function variants in the PTPN2 gene are associated with increased risk of inflammatory bowel disease. We recently showed that Ptpn2 is critical for intestinal epithelial cell (IEC) barrier maintenance, IEC–macrophage ...
Vinicius Canale, Marianne R. Spalinger, Rocio Alvarez, Anica Sayoc-Becerra, Golshid Sanati, Salomon Manz, Pritha Chatterjee, Alina N. Santos, Hillmin Lei, Sharon Jahng, Timothy Chu, Ali Shawki, Elaine Hanson, Lars Eckmann, André J. Ouellette, Declan F. McCole   +15 more
doaj   +5 more sources

PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis [PDF]

JCI Insight, 2020
Loss-of-function variants of protein tyrosine phosphatase non-receptor type 2 (PTPN2) enhance risk of inflammatory bowel disease and rheumatoid arthritis; however, whether the association between PTPN2 and autoimmune arthritis depends on gut inflammation
Wan-Chen Hsieh, Mattias N.D. Svensson, Martina Zoccheddu, Michael L. Tremblay, Shimon Sakaguchi, Stephanie M. Stanford, Nunzio Bottini   +6 more
doaj   +3 more sources