Results 31 to 40 of about 3,009 (161)
PTPN2 attenuates T-cell lymphopenia-induced proliferation [PDF]
Nature Communications, 2014 When the peripheral T-cell pool is depleted, T cells undergo homoeostatic expansion. This expansion is reliant on the recognition of self-antigens and/or cytokines, in particular interleukin-7. The T cell-intrinsic mechanisms that prevent excessive homoeostatic T-cell responses and consequent overt autoreactivity remain poorly defined.
Florian, Wiede +2 more
openaire +2 more sources
Frontiers in Immunology, 2020 Protein tyrosine phosphatase non-receptor type 2 (PTPN2) plays a pivotal role in immune homeostasis and has been associated with human autoimmune and chronic inflammatory diseases.
Larissa Hering +15 more
doaj +1 more source
PTPN2, a potential therapeutic target for type 1 diabetes? [PDF]
Arquivos Brasileiros de Endocrinologia & Metabologia, 2014 We read with great interest the article by Rheinheimer and cols. (), showing that four hundred and eighty six patients with type 1 diabetes (T1D) and 484 non-diabetic subjects were conducted to discuss the rs1893217 (T/C) polymorphism in protein tyrosine phosphatase, non-receptor type 2 gene (PTPN2) gene for T1D from Southern Brazil, by which the C ...
Liu, Shan-Shan, Ji-Quan, Lou, Ye, Ding
openaire +3 more sources
PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells
Cell Reports, 2020 Summary: Manipulating molecules that impact T cell receptor (TCR) or cytokine signaling, such as the protein tyrosine phosphatase non-receptor type 2 (PTPN2), has significant potential for advancing T cell-based immunotherapies.
Markus Flosbach +13 more
doaj +1 more source
Association of genetic variations in PTPN2 and CD122 with ocular Behcet’s disease [PDF]
British Journal of Ophthalmology, 2018 BackgroundProtein tyrosine phosphatases (PTPs) play critical roles in human autoimmunity. Previous studies found that PTPN2 may be the key regulatory factor in the T-cell-mediated immune response. PTPN2 regulates the Janus kinase/signal transducers and activators of transcription pathway by inhibiting signalling via the interleukin (IL)-2 receptor ...
Zhang, Qi +9 more
openaire +3 more sources
Journal of Diabetes Research, 2018 Objective. Inflammation plays a major role in albuminuria in type 2 diabetes mellitus (T2DM). Our previous studies have shown that the expression of vitamin D receptor (VDR) is downregulated in T2DM which is closely associated with the severity of ...
Li Zheng +6 more
doaj +1 more source
Blood Advances, 2019 : Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) is a phosphatase known to be a tumor suppressor gene in T-cell acute lymphoblastic leukemia (T-ALL). Because the full clinicobiologic characteristics of PTPN2 loss remain poorly reported, we aimed
Marion Alcantara +16 more
doaj +1 more source
The presence of genetic risk variants within PTPN2 and PTPN22 is associated with intestinal microbiota alterations in Swiss IBD cohort patients. [PDF]
PLoS ONE, 2018 BACKGROUND:Genetic risk factors, intestinal microbiota and a dysregulated immune system contribute to the pathogenesis of inflammatory bowel disease (IBD). We have previously demonstrated that dysfunction of protein tyrosine phosphatase non-receptor type
Bahtiyar Yilmaz +9 more
doaj +1 more source
A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity
Nature Communications, 2023 The inhibition of protein tyrosine phosphatases 1B (PTP1B) and N2 (PTPN2) has emerged as an exciting approach for bolstering T cell anti-tumor immunity. ABBV-CLS-484 is a PTP1B/PTPN2 inhibitor in clinical trials for solid tumors.
Shuwei Liang +13 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Introduction: The energy imbalance when energy intake exceeds expenditure acts as an essential factor in the development of insulin resistance (IR). The activity of brown adipose tissue, which is involved in the dissipation of energy via heat expenditure
Yapeng Liu +9 more
doaj +1 more source