Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex
Communications ChemistryPTPN2 (protein tyrosine phosphatase non-receptor type 2, or TC-PTP) and PTPN1 are attractive immuno-oncology targets, with the deletion of Ptpn1 and Ptpn2 improving response to immunotherapy in disease models.
Qi Hao +28 more
doaj +3 more sources
Impact of genotyping (PTPN2, rs2542151) and (MBOAT7, rs641738) in prediction of fibrosis in Metabolic dysfunction- associated steatotic liver disease’ patients [PDF]
Frontiers in EndocrinologyIntroductionNumerous risk loci have been identified to have an essential role in Metabolic associated steatotic liver disease (MASLD) susceptibility and progression.
Shimaa Abdelsattar +14 more
doaj +2 more sources
PTPN2 can be a potential target for the treatment of psoriasis
Pifu-xingbing zhenliaoxue zazhiObjective To investigate the expression and regulatory mechanism of PTPN2 in psoriasis, and to analyze the effects of PTPN2 on psoriasis related immunity in order to determine whether PTPN2 can be used as a potential therapeutic target for psoriasis ...
Shougang LIU, Fanghua LIU, Yongfeng CHEN
doaj +2 more sources
Deletion of Ptpn2 in B cells promotes autoimmunity via TLR and JAK/STAT signaling [PDF]
JCI InsightAutoimmunity arises when self-reactive B and T cells target the body’s own tissues, with B cells contributing through antigen presentation as well as production of autoantibodies and proinflammatory cytokines.
Bridget N. Alexander +8 more
doaj +2 more sources
PTPN2 inhibits TG-induced ERS-initiated TNBC apoptosis through the mitochondrial pathway [PDF]
Scientific ReportsTriple negative breast cancer (TNBC) is the most malignant subtype of breast cancer that portends a poor prognosis and limited treatment. PTPN2 is a member of the non-receptor protein tyrosine phosphatase family that regulates biological processes by ...
Yanhe An +3 more
doaj +2 more sources
Frontiers in Cellular and Infection Microbiology, 2018 A shared genetic pre-disposition, chronic inflammation, and treatment with similar biologics between Rheumatoid arthritis (RA) and Crohn's disease (CD) have intrigued us to investigate whether the two disorders share trigger association or possible ...
Saleh Naser +2 more
exaly +3 more sources
PTPN2 Inhibition Disrupts Mitochondrial Renewal and Blocks TFRC‐Mediated Mitophagy to Exert Anti‐Tumor Activities in ALK‐Positive Anaplastic Large Cell Lymphoma [PDF]
Advanced ScienceAnaplastic large cell lymphoma (ALCL) is a heterogeneous subtype of T‐cell lymphoma usually driven by genetic alterations affecting the anaplastic lymphoma kinase (ALK) gene.
Wei‐Ting Wang +11 more
doaj +2 more sources
PTPN2 as a promoter of colon carcinoma via reduction of inflammasome activation [PDF]
Molecular & Cellular Oncology, 2018 We have recently demonstrated that macrophage-specific loss of Protein tyrosine phosphatase non-receptor type 2 (PTPN2) promotes inflammasome activation, resulting in protection from colorectal cancer.
Marianne R. Spalinger, Michael Scharl
doaj +4 more sources
Silencing PTPN2 with nanoparticle-delivered small interfering RNA remodels tumor microenvironment to sensitize immunotherapy in hepatocellular carcinoma [PDF]
Acta Pharmaceutica Sinica BProtein tyrosine phosphatase nonreceptor type 2 (PTPN2) is a promising target for sensitizing solid tumors to immune checkpoint blockades. However, the highly polar active sites of PTPN2 hinder drug discovery efforts.
Fu Wang +12 more
doaj +2 more sources
Identifying Donor Immune Cells in the Intestinal Mucosa of Chimeric Recipient Mice by Immunofluorescence. [PDF]
Curr ProtocAbstract Murine competitive congenic bone marrow transplantation is an important method used to identify genetic contributions to immune cell abundance, activation, differentiation, and mobilization, either in the bone marrow or in the peripheral organs of the host.
Canale V +5 more
europepmc +2 more sources