Results 41 to 50 of about 3,009 (161)

Protein tyrosine phosphatase non-receptor type 2 as the therapeutic target of atherosclerotic diseases: past, present and future

Frontiers in Pharmacology, 2023
Tyrosine-protein phosphatase non-receptor type 2(PTPN2), an important member of the protein tyrosine phosphatase family, can regulate various signaling pathways and biological processes by dephosphorylating receptor protein tyrosine kinases. Accumulating
Xiao-Er Tang, Ya-Qiong Cheng, Chao-Ke Tang   +2 more
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Inhibition of PTPN2 by PTP inhibitor V

Bulletin of the Korean Chemical Society, 2013
Protein phosphorylation is closely linked to critical pathways in numerous human diseases, which is regulated by the coordinated activities of kinases and phosphatases. Protein phosphorylation occurs predominantly on serine, threonine, and tyrosine residues of proteins and plays important roles in the regulation of physiological processes including ...
Younghyun Kim, Sayeon Cho
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Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin’s lymphoma and T-cell non-Hodgkin’s lymphoma

Haematologica, 2011
We recently reported deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia. Functional analyses confirmed that PTPN2 acts as classical tumor suppressor repressing the proliferation of T cells, in part through ...
Maria Kleppe, Thomas Tousseyn, Eva Geissinger, Zeynep Kalender Atak, Stein Aerts, Andreas Rosenwald, Iwona Wlodarska, Jan Cools   +7 more
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Molecular and clinical characterization of PTPN2 expression from RNA-seq data of 996 brain gliomas

Journal of Neuroinflammation, 2018
Background Immune checkpoint inhibitors have been shown to promote antitumor immunity and achieve durable tumor remissions. However, certain tumors are refractory to current immunotherapy. These negative results encouraged us to uncover other therapeutic
Peng-fei Wang, Hong-qing Cai, Chuan-bao Zhang, Yan-Michael Li, Xiang Liu, Jing-hai Wan, Tao Jiang, Shou-wei Li, Chang-Xiang Yan   +8 more
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PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer

Cell Reports, 2018
Summary: Variants in the gene locus encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) are associated with inflammatory disorders, including inflammatory bowel diseases, rheumatoid arthritis, and type 1 diabetes. The anti-inflammatory role
Marianne R. Spalinger, Roberto Manzini, Larissa Hering, Julianne B. Riggs, Claudia Gottier, Silvia Lang, Kirstin Atrott, Antonia Fettelschoss, Florian Olomski, Thomas M. Kündig, Michael Fried, Declan F. McCole, Gerhard Rogler, Michael Scharl   +13 more
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Characterization of novel dual PTPN1 and PTPN2 inhibitors

, 2023
Abstract Nonreceptor tyrosine phosphatases (NTPs) play an important role regulating protein phosphorylation and have been proposed as attractive therapeutic targets for different diseases. We have previously identified that 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one (HODHBt) enhanced STAT activation upon cytokine treatment.
Alberto Bosque, J Natalie Howard, Thomas Zaikos, Callie Levinger, Esteban Rivera, Elyse McMahon, Marta Sanz, Dennis Copertino, Weisheng Wang, Natalia Soriano-Sarabia, R. Brad Jones   +10 more
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In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target [PDF]

Nature, 2017
Immunotherapy with PD-1 checkpoint blockade is effective in only a minority of patients with cancer, suggesting that additional treatment strategies are needed. Here we use a pooled in vivo genetic screening approach using CRISPR-Cas9 genome editing in transplantable tumours in mice treated with immunotherapy to discover previously undescribed ...
Robert T, Manguso, Hans W, Pope, Margaret D, Zimmer, Flavian D, Brown, Kathleen B, Yates, Brian C, Miller, Natalie B, Collins, Kevin, Bi, Martin W, LaFleur, Vikram R, Juneja, Sarah A, Weiss, Jennifer, Lo, David E, Fisher, Diana, Miao, Eliezer, Van Allen, David E, Root, Arlene H, Sharpe, John G, Doench, W Nicholas, Haining   +18 more
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Role ofPTPN2/22polymorphisms in pathophysiology of Crohn’s disease

World Journal of Gastroenterology, 2018
To establish the relationship of protein tyrosine phosphatase non-receptor type 2 and 22 (PTPN2/22) polymorphisms and mycobacterial infections in Crohn's disease (CD).All 133 subjects' blood samples were genotyped for nine single nucleotide polymorphisms (SNPs) in PTPN2/22 using TaqMan™ genotyping, while the effect of the SNPs on PTPN2/22 and IFN-γ ...
Sharp, Robert C., Beg, Shazia A., Naser, Saleh A.   +2 more
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DOP53 PTPN2 and TiO2 in the pathogenesis of inflammatory bowel disease [PDF]

Journal of Crohn's and Colitis, 2020
Abstract Background Inflammatory bowel disease (IBD) is caused by a complex interaction among genetic, immunological, bacterial and environmental factors. In this scenario, protein tyrosine phosphatase non-receptor type-2 (PTPN2) has been recognised as a risk factor for the development of IBD and ...
Conde, J, Schwarzfischer, M, Katkeviciute, E, Häfliger, J, Niechcial, A, Brillant, N, Atrott, K, Bäbler, K, Scharl, M   +8 more
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Activation of protein tyrosine phosphatase non-receptor type 2 by spermidine exerts anti-inflammatory effects in human THP-1 monocytes and in a mouse model of acute colitis. [PDF]

PLoS ONE, 2013
Spermidine is a dietary polyamine that is able to activate protein tyrosine phosphatase non-receptor type 2 (PTPN2). As PTPN2 is known to be a negative regulator of interferon-gamma (IFN-γ)-induced responses, and IFN-γ stimulation of immune cells is a ...
Belén Morón, Marianne Spalinger, Stephanie Kasper, Kirstin Atrott, Isabelle Frey-Wagner, Michael Fried, Declan F McCole, Gerhard Rogler, Michael Scharl   +8 more
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