Results 51 to 60 of about 3,009 (161)

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Pan-cancer analysis revealing that PTPN2 is an indicator of risk stratification for acute myeloid leukemia

Scientific Reports, 2023
The non-receptor protein tyrosine phosphatases gene family (PTPNs) is involved in the tumorigenesis and development of many cancers, but the role of PTPNs in acute myeloid leukemia (AML) remains unclear. After a comprehensive evaluation on the expression
Xuanyu Wang, Sanyun Wu, Le Sun, Peipei Jin, Jianmin Zhang, Wen Liu, Zhuo Zhan, Zisong Wang, Xiaoping Liu, Li He   +9 more
doaj   +1 more source

Modulation of the Mucosa-Associated Microbiome Linked to the PTPN2 Risk Gene in Patients with Primary Sclerosing Cholangitis and Ulcerative Colitis

Microorganisms, 2021
Gut microbiota appears to be involved in the pathogenesis of primary sclerosing cholangitis (PSC). The protein tyrosine phosphatase nonreceptor 2 (PTPN2) gene risk variant rs1893217 is associated with gut dysbiosis in inflammatory bowel disease (IBD ...
Luisa Denoth, Pascal Juillerat, Andreas E. Kremer, Gerhard Rogler, Michael Scharl, Bahtiyar Yilmaz, Sena Bluemel, on behalf of the Swiss IBD Cohort Study   +7 more
doaj   +1 more source

TNFSF14/LIGHT responses in intestinal and oesophageal fibroblasts are differentially modulated by hydroxylase inhibitors

The Journal of Physiology, EarlyView.
Abstract figure legend LIGHT is a mutual mediator of intestinal and oesophageal fibroblast inflammation with common as well as tissue‐specific effects. Hydroxylase inhibitors can selectively suppress inflammatory factors in both cell types, albeit targeting different signalling pathways.
Cian M. Ohlendieck, Carlos Matellan, Cristina Bauset, Bella Raphael, Mary Nwaezeigwe, Emer Flynn, Kevin Okamoto, Desmond Winter, Colm Collins, Katie Doogan, Seán T. Martin, Glen Doherty, Seema S. Aceves, Mario C. Manresa   +13 more
wiley   +1 more source

Wedelolactone improves the renal injury induced by lipopolysaccharide in HK-2 cells by upregulation of protein tyrosine phosphatase non-receptor type 2

Journal of International Medical Research, 2021
Objective To explore the effects of wedelolactone (WEL) on sepsis-induced renal injury in the human renal proximal tubular epithelial cell line HK-2. Methods HK-2 cells were stimulated by 1 µg/ml lipopolysaccharide (LPS) to trigger renal injury in vitro .
Deyuan Zhi, Meng Zhang, Jin Lin, Pei Liu, Yajun Wang, Meili Duan   +5 more
doaj   +1 more source

PTPN2 Loss Sensitizes Tumor Cells to Immunotherapy [PDF]

Cancer Discovery, 2017
Abstract Ptpn2 loss increases tumor cell IFNγ signaling to enhance antigen presentation and antitumor immunity.
openaire   +1 more source

Patient‐Derived Organoid‐Based CRISPR Screens in Cancer Research: Applications, Advances, and Challenges

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Patient‐derived organoids (PDOs) have emerged as physiologically relevant cancer models that preserve key genetic, histological, and functional features of the tumors from which they are derived. In parallel, CRISPR‐based perturbation technologies have transformed functional genomics by enabling scalable interrogation of gene function.
Julianne du Plessis, Aadilah Omar
wiley   +1 more source

Regulation of platelet-activating factor-mediated interleukin-6 promoter activation by the 48 kDa but not the 45 kDa isoform of protein tyrosine phosphatase non-receptor type 2

Cell & Bioscience, 2019
Background An underlying state of inflammation is thought to be an important cause of cardiovascular disease. Among cells involved in the early steps of atherosclerosis, monocyte-derived dendritic cells (Mo-DCs) respond to inflammatory stimuli, including
Geneviève Hamel-Côté, Fanny Lapointe, Steeve Véronneau, Marian Mayhue, Marek Rola-Pleszczynski, Jana Stankova   +5 more
doaj   +1 more source

PTPN2 deficiency: Amping up JAK/STAT

Journal of Experimental Medicine
Identification of monogenic causes of immune dysregulation provides insight into human immune response and signaling pathways associated with autoimmunity. Here, Jeanpierre et al. (https://doi.org/10.1084/jem.20232337) identify new germline variants in the gene encoding PTPN2 associated with loss of regulatory function, enhanced JAK/STAT signaling, and
Joshua M. Tobin, Megan A. Cooper
openaire   +2 more sources

COMPASS: A Computational Pipeline to Identify Linkers Predicting Ubiquitinable PROTAC‐Induced Ternary Complexes

ChemMedChem, Volume 21, Issue 14, 29 July 2026.
COMPASS enables structure‐based screening of PROTAC linker libraries by jointly evaluating ternary complex formation and ubiquitination competence. The pipeline accurately recovers experimentally observed ternary complex geometries and identifies linkers unlikely to support productive degradation. By eliminating unproductive candidates before synthesis,
Sébastien Sueron, Sayyed Jalil Mahdizadeh, Eric Chevet, Xavier Guillory, François‐Hugues Porée, Leif A. Eriksson   +5 more
wiley   +1 more source