Results 61 to 70 of about 3,009 (161)
Functional immune profiling reveals CD4+ T cell dysregulation in coeliac disease
Immunology &Cell Biology, Volume 104, Issue 6, Page 613-630, July 2026.The T cell momentum assay quantifies division, survival and activation decay to reveal intrinsic CD4+ programming defects marked by prolonged activation and impaired feedback control in coeliac disease. This scalable platform provides a functional screen for early T cell dysregulation across autoimmune and immune‐mediated diseases.
Anthony J Farchione +13 more
wiley +1 more source
Inducible CRISPR/Cas systems in precision oncology: Current applications and future perspectives
Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.Inducible CRISPR/Cas systems enable spatiotemporal genome editing in precision oncology. Chemical, optical, physical, and microenvironmental stimuli provide distinct control strategies. Conditional activation may reduce off‐target exposure and basal nuclease activity.
Ziliang Ding +3 more
wiley +1 more source
Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma
eFood, Volume 7, Issue 3, June 2026.Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie +5 more
wiley +1 more source
PTPN2 is Associated with Crohn’s Disease and Its Expression Is Regulated by NKX2-3 [PDF]
Disease Markers, 2012 PTPN2 is a risk gene for Crohn's disease (CD). We investigated whether PTPN2 genetic variants (rs2542151 and rs2542152) were associated with CD in a familial IBD registry. Both rs2542151 and rs2542152 are associated with CD, but not ulcerative colitis (UC).
Yu, Wei +9 more
openaire +2 more sources
Cellular Physiology and Biochemistry, 2018 Background/Aims: Dysregulated inflammation in adipose tissue, marked by increased pro-inflammatory T-cell accumulation and reduced regulatory T cells (Treg), contributes to diabetes-associated insulin resistance and atherosclerosis.
Ya Li +9 more
doaj +1 more source
JCI Insight, 2023 Macrophages intimately interact with intestinal epithelial cells, but the consequences of defective macrophage–epithelial cell interactions for protection against enteric pathogens are poorly understood.
Marianne R. Spalinger +9 more
doaj +1 more source
Presence of PTPN2 SNP rs1893217 Enhances the Anti-inflammatory Effect of Spermidine
Inflammatory Bowel Diseases, 2020 Abstract Background The single nucleotide polymorphism (SNP) rs1893217 within the gene locus encoding PTPN2 represents a risk factor for inflammatory bowel disease (IBD). Our previous work demonstrated reduced PTPN2 activity and subsequently increased inflammatory signaling upon presence of SNP ...
Niechcial, Anna +10 more
openaire +6 more sources
Roles of miR-210 in the pathogenesis of pre-eclampsia
Archives of Medical Science, 2018 Introduction This study aimed to explore the bio-function of miR-210 in the pathogenesis of pre-eclampsia and provide new insights into the diagnosis and treatment of pre-eclampsia.
Jiyun Li, Guimei Wu, Yanmin Cao, Zhi Hou
doaj +1 more source
Altered Expression of Dual‐Specificity Phosphatases in Macrophages Exposed to Lipid Nanoparticles
FASEB BioAdvances, Volume 8, Issue 5, May 2026.Rapid responses to infection and tissue injury rely on constitutively expressed proteins that are activated by posttranslational modifications, primarily phosphorylation. Feedback regulation involves phosphatases that remove phosphate groups, attenuating the response and constituting a cellular molecular off switch. Dual‐specificity phosphatases (DUSPs)
David M. Cauvi +4 more
wiley +1 more source
Research, 2022 Improving the efficacy of melanoma treatment remains an important global challenge. Here, we combined chemotherapy with protein tyrosine phosphatase nonreceptor type 2(Ptpn2) based immunotherapy in an effort to address this challenge.
Chengli Yang +8 more
doaj +1 more source