Results 81 to 90 of about 3,009 (161)

Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans.

PLoS ONE, 2013
ObjectivesGenome-wide association studies have facilitated the identification of over 30 susceptibility loci for rheumatoid arthritis (RA). However, evidence for a number of potential susceptibility genes have not so far reached genome-wide significance ...
Joanna E Cobb, Darren Plant, Edward Flynn, Meriem Tadjeddine, Philippe Dieudé, François Cornélis, Lisbeth Ärlestig, Solbritt Rantapää Dahlqvist, George Goulielmos, Dimitrios T Boumpas, Prodromos Sidiropoulos, Sophine B Krintel, Lykke M Ørnbjerg, Merete L Hetland, Lars Klareskog, Thomas Haeupl, Andrew Filer, Christopher D Buckley, Karim Raza, Torsten Witte, Reinhold E Schmidt, Oliver FitzGerald, Douglas Veale, Stephen Eyre, Jane Worthington   +24 more
doaj   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Molecular Mechanisms and Targeted Therapies of PTPN2 in Metabolic Diseases: A Review

Biomolecules
Metabolic disorders encompass a spectrum of pathologies driven by the dysregulation of systemic metabolic homeostasis. Their escalating global prevalence has positioned these conditions at the forefront of contemporary biomedical research.
Yue Yuan, Jing Xie, Mo Wang, Yishan Li, Xinxin Zhang, Zunjie Bo, Lei Sun, Ajing Xu   +7 more
doaj   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

PTPN2 Gene [PDF]

, 2020
openaire   +1 more source

Ptpn2: A Critical Regulator of Paneth Cell Homeostasis

Cellular and Molecular Gastroenterology and Hepatology, 2023
openaire   +2 more sources

PTPN2 wt Allele [PDF]

, 2020
openaire   +1 more source

PTPN2: a tumor suppressor you want deleted? [PDF]

Immunology & Cell Biology, 2017
Florian Wiede, Tony Tiganis
openaire   +1 more source

PTPN2 copper-sensing relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression

Nature Communications
Fluxes in human copper levels recently garnered attention for roles in cellular signaling, including affecting levels of the signaling molecule cyclic adenosine monophosphate.
Matthew O. Ross, Yuan Xie, Ryan C. Owyang, Chang Ye, Olivia N. P. Zbihley, Ruitu Lyu, Tong Wu, Pingluan Wang, Olga Karginova, Olufunmilayo I. Olopade, Minglei Zhao, Chuan He   +11 more
doaj   +1 more source

The HIV latency reversing agent HODHBt inhibits the phosphatases PTPN1 and PTPN2

JCI Insight
Nonreceptor tyrosine phosphatases (NTPs) play an important role in regulating protein phosphorylation and have been proposed as attractive therapeutic targets for cancer and metabolic diseases.
J. Natalie Howard, Thomas D. Zaikos, Callie Levinger, Esteban Rivera, Elyse K. McMahon, Carissa S. Holmberg, Joshua Terao, Marta Sanz, Dennis C. Copertino Jr., Weisheng Wang, Natalia Soriano-Sarabia, R. Brad Jones, Alberto Bosque   +12 more
doaj   +1 more source