Results 91 to 100 of about 3,009 (161)

HIT101308137 and HIT104293658 nominate dual target chemotypes for PTPN1 and PTPN2 with preliminary selectivity in colorectal cancer cells. [PDF]

Front Chem
Huang C, Chen J, Chen R, Cao L.
europepmc   +1 more source

CRISPR-screen informed engineered T cell therapies. [PDF]

Front Immunol
Wong K, Calnan C, Benson MJ.
europepmc   +1 more source

PTPN1/PTPN2 inhibition improves NK cancer therapy by enhancing IL-2 and mitigating TGFβ1 responses. [PDF]

EMBO Rep
Feng CH, Peltier L, Chouleur T, DiPonzio M, Aubry I, Poirier AJ, Cordova ZM, Shen Y, Tabariès S, Cao X, Chen G, Bikfalvi A, Vidal SM, Siegel PM, Laneuville P, Tremblay ML.   +15 more
europepmc   +1 more source

Negative correlation between microRNA and insulin sensitivity gene expression in adipose tissue: potential implications for diabetes and neurodegenerative diseases. [PDF]

Nutr Metab (Lond)
Podraza J, Wąsowski M, Jonas MI, Lisik W, Jonas M, Binda A, Jaworski P, Tarnowski W, Noszczyk B, Puzianowska-Kuźnicka M, Kuryłowicz A.   +10 more
europepmc   +1 more source

An integrated microbiome-drug interaction and bioinformatics approach identifies active deglycosylated and glycosidic chain metabolites of Platycodin D targeting PTPN2/HIF1A in acute lung injury. [PDF]

Biol Direct
Zhong Y, Peng Y, Zhang S, Wen L, Liu G, Xu B, Liang Y, Huang H, He J, Feng Y, Zeng J, Liang J.   +11 more
europepmc   +1 more source

Indirect inhibition of the NLRP3-interleukin-1β axis contributes to the efficacy of JAK1 inhibitors in experimental colitis and human ulcerative colitis. [PDF]

Nat Commun
Liu B, Spalinger MR, Invernizzi A, Gerdes E, Steglich B, Schwarzfischer M, Machicote A, Pelczar P, Pöhlmann D, Nawrocki M, Böttcher M, Aleko A, Velasquez LN, Wende S, Stallbaum F, Neuendorff J, Grosshauser S, Muscate F, Douilhet G, Perez LG, Sabihi M, Möller K, Viehweger F, Sutter JP, Kilian C, Kumar Y, Fründt T, Sauter G, Rösch T, Gagliani N, Caflisch A, Scharl M, Huber S.   +32 more
europepmc   +1 more source

Phosphatase targeting in basal-like breast cancer: PTPN2.

Breast cancer can be distinguished into two broad groups, luminal and basal, based on cytologic, morphologic, cytoskeletal and differentiation-based features.  While luminal breast cancers can be positive for expression of a hormone receptor (ESR/PGR/AR) or a growth factor receptor (ERBB2) and targeted accordingly clinically, basal-like breast cancers ...
openaire   +1 more source

Mitochondria as Epigenetic Regulators of β-Cell Identity and Plasticity: A Metabolo-Epigenetic Perspective. [PDF]

Cells
Kim Y.
europepmc   +1 more source

Host genome regulation of the porcine gut microbiota and its impact on feed conversion efficiency. [PDF]

Anim Microbiome
Wu Q, Wang X, Mu Q, Tian J, Wang H, Yang J, Peng Z, Gao L, Gao P, Zhao F.   +9 more
europepmc   +1 more source

Genome-Wide Association Analysis of the Sperm Motility Traits of Jinding Drakes. [PDF]

Animals (Basel)
Zhu C, Gu H, Wang Z, Song W, Tao Z, Zhang S, Chen L, Li H, Liu H.   +8 more
europepmc   +1 more source