Results 211 to 220 of about 105,512 (249)

A Cell Type-Specific Role of Protein Tyrosine Phosphatase Non-Receptor Type 2 in Regulating ER Stress Signalling

Digestion, 2015
<b><i>Background/Aims:</i></b> Genetic polymorphisms within the gene locus encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) have been associated with inflammatory bowel disease (IBD). A recent study demonstrated that PTPN2 regulates ER stress signalling in pancreatic β-cells.
Kasper Stephanie H, Spalinger Marianne R, Raselli Tina, Scharl Michael   +3 more
openaire   +3 more sources

Protein Tyrosine Phosphatase non-Receptor Type 2 regulates IFN-γ-induced cytokine signaling in THP-1 monocytes

Inflammatory Bowel Diseases, 2010
We have previously shown that the Crohn's disease (CD)-associated gene protein tyrosine phosphatase non-receptor Type 2 (PTPN2) regulates interferon gamma (IFN-γ)-induced signaling and barrier function in intestinal epithelial cells. Overactivation of immature immune cells has been demonstrated in CD and elevated levels of proinflammatory cytokines ...
Scharl Michael, Hruz Petr, McCole Declan F   +2 more
openaire   +2 more sources

AB0114 Comparative Analysis of the Expression of Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2) in Autoimmune Disease

Annals of the Rheumatic Diseases, 2014
Background Protein Tyrosine Phosphatase Non-receptor Type 2 (PTPN2) is a phosphatase that plays an important role in inhibiting T-cell activation. The PTPN2 gene contains SNPs that are risk factors for the development of rheumatoid arthritis (RA), Crohn9s disease and type 1 diabetes.
B. Aradi, M. Armaka, M. Filková, M. Kato, K. Klein, M. Scharl, B.A. Michel, L. Senolt, R.E. Gay, E.I. Buzás, G. Kollias, S. Gay, A. Jüngel   +12 more
openaire   +1 more source

Protein tyrosine phosphatase non‐receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population

Tissue Antigens, 2008
AbstractProtein tyrosine phosphatase non‐receptor type 22 (PTPN22) is considered an important regulator of T‐cell activation. Polymorphisms within the PTPN22 gene have been suggested to confer susceptibility to autoimmune endocrine disorders. To evaluate the impact of a functional variation in the PTPN22 gene in type 1 (T1D) and type 2 diabetes (T2D ...
K, Douroudis, E, Prans, K, Haller, V, Nemvalts, T, Rajasalu, V, Tillmann, K, Kisand, R, Uibo   +7 more
openaire   +2 more sources

MicroRNA-448 promotes multiple sclerosis development through induction of Th17 response through targeting protein tyrosine phosphatase non-receptor type 2 (PTPN2)

Biochemical and Biophysical Research Communications, 2017
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system, and its pathogenesis remains largely unclear. Much attention has been paid to the role of microRNAs (miRs) in regulation of autoimmune disease. Here, we found, for the first time, that miR-448 expression was significantly increased in periphery blood ...
Rihan, Wu, Qinyu, He, Haitao, Chen, Miao, Xu, Ning, Zhao, Ying, Xiao, Qian-Qian, Tu, Wenjun, Zhang, Xiaoying, Bi   +8 more
openaire   +2 more sources

Targeting protein tyrosine phosphatase non-receptor type 2 with a novel inhibitor for AML therapy

Abstract Acute myeloid leukemia (AML) is a fatal disease characterized by a bleak prognosis. For over four decades, treatment options for AML have been constrained to administering high-dose cytotoxic chemotherapy. However, the emergence of drug resistance and the resultant toxic side effects have created an urgent necessity for ...
Wenbin Kuang, Jinxin Jiang, Xiao Wang, Dawei Wang, Minghui Ji, Yasheng Zhu, Kai Yuan, Jiayu Ding, Wenmu Wang, Mingge Song, Wenjian Min, Fei Huang, Liping Wang, Wanjian Gu, Haiping Hao, Yibei Xiao, Peng Yang   +16 more
openaire   +1 more source

The Crohn's Disease Candidate Gene, Protein Tyrosine Phosphatase Non-Receptor Type 2, Regulates Muramyldipetide-Induced NOD2-Dependent Effects in Human Monocytes and Fibroblasts

Gastroenterology, 2011
Background: Mutations within the gene loci, encoding protein tyrosine phosphatase nonreceptor type 2 (PTPN2) and nucleotide oligomerization domain 2 (NOD2), have been associated with Crohn's disease (CD). We have recently shown that PTPN2 limits proinflammatory effects in human intestinal epithelial cells (IEC) and monocytes.
Michael Scharl, Kacper A. Wojtal, Anne Fischbeck, Joba M. Arikkat, Theresa Pesch, Silvia Kellermeier, Stephan R. Vavricka, Michael Fried, Declan F. McCole, Gerhard Rogler   +9 more
openaire   +1 more source

[Affect of protein tyrosine phosphatase non-receptor type 2 and nuclear factor-kappaB on periodontal destruction with diabetes].

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2015
To investigate the expression of protein tyrosine phosphatase non-receptor type 2 (PTPN2) and nuclear factor-kappaB (NF-kappaB), as well as the relationship between their expression and periodontal destruction in mice with diabetic periodontitis.Four weeks old healthy C57BL/6J mice were randomly divided into normal control group (Group N ...
Hao, Li, Weil, Li, Yi, Ding, Bin, Guo, Honghui, Xie, Min, Fu, Qi, Wang   +6 more
openaire   +1 more source

Pathophysiology of rheumatoid arthritis is associated with polymorphisms in Protein Tyrosine Phosphatase Non-receptor type 2 and 22 (PTPN2/22) and susceptibility to Mycobacteria

The Journal of Immunology, 2018
Abstract Single nucleotide polymorphisms (SNPs) in T-cell regulator genes such as Protein Tyrosine Phosphatase Non-receptor type 2 and 22 (PTPN2/22) have been associated with many inflammatory autoimmune disorders including rheumatoid arthritis (RA).
Robert C Sharp, Shazia A Beg, Saleh A Naser   +2 more
openaire   +1 more source

Protein Tyrosine Phosphatase Non-Receptor Type 2 is a Regulator of Authophagosome Function

Gastroenterology, 2011
Michael Scharl, Kacper A. Wojtal, Helen M. Becker, Anne Fischbeck, Joba M. Arikkat, Theresa Pesch, Silvia Kellermeier, David L. Boone, Achim Weber, Pascal Frei, Stephan R. Vavricka, Michael Fried, Declan F. McCole, Gerhard Rogler   +13 more
openaire   +1 more source