Results 71 to 80 of about 3,688,591 (305)

Inhibition of Trypanosoma evansi Protein-Tyrosine Phosphatase by Myristic Acid Analogues Isolated from Khaya senegalensis and Tamarindus indica

Journal of Experimental Pharmacology, 2019
Emeka John Dingwoke,1 Fatima Amin Adamude,2 Chimee Ethel Chukwuocha,1 Ahmed Adamu Ambi,1 Nwobodo Ndubuisi Nwobodo,3,4 Abdullahi Balarabe Sallau,1 Humphrey Chukwuemeka Nzelibe1 1Department of Biochemistry, Faculty of Life Sciences, Ahmadu Bello University,
Dingwoke EJ, Adamude FA, Chukwuocha CE, Ambi AA, Nwobodo NN, Sallau AB, Nzelibe HC   +6 more
doaj  

The EYA tyrosine phosphatase activity is pro-angiogenic and is inhibited by benzbromarone.

PLoS ONE, 2012
Eyes Absents (EYA) are multifunctional proteins best known for their role in organogenesis. There is accumulating evidence that overexpression of EYAs in breast and ovarian cancers, and in malignant peripheral nerve sheath tumors, correlates with tumor ...
Emmanuel Tadjuidje, Tim Sen Wang, Ram Naresh Pandey, Saulius Sumanas, Richard A Lang, Rashmi S Hegde   +5 more
doaj   +1 more source

Systemic Nanomechanical Single‐Cell Profiling Reveals Mechanophenotype Transitions Under Therapeutic Perturbation

Advanced Science, EarlyView.
Single‐cell mechanomics demonstrates that pharmacological perturbation changes cytoskeletal and cortical structure, suppressing cancer cell invasiveness. By integrating atomic force microscopy (AFM)‐based cortical measurements with stimulated emission depletion (STED)‐resolved adhesion and cytoskeletal organization, this approach identifies nanoscale ...
Minhee Ku, Jinwon Kwon, Nara Yoon, Hyung Kwon Byeon, Jaemoon Yang   +4 more
wiley   +1 more source

Liprin-α4 is required for nickel induced receptor protein tyrosine phosphatase-leukocyte antigen related receptor F (RPTP-LAR) activity.

PLoS ONE, 2011
Liprin-α4 was strongly induced following nickel (II) chloride exposure in a variety of cell types including BEAS-2B, A549, BEP2D and BL41 cells. Liprin-α4, a member of the Liprin alpha family, has seven isoforms but only three of these variants were ...
Kathrin Kiok, Hong Sun, Hailey Clancy, Sutapa Bose, Thomas Kluz, Fen Wu, Max Costa   +6 more
doaj   +1 more source

Regulation of brown fat adipogenesis by protein tyrosine phosphatase 1B. [PDF]

PLoS ONE, 2011
Protein-tyrosine phosphatase 1B (PTP1B) is a physiological regulator of insulin signaling and energy balance, but its role in brown fat adipogenesis requires additional investigation.To precisely determine the role of PTP1B in adipogenesis, we ...
Kosuke Matsuo, Ahmed Bettaieb, Naoto Nagata, Izumi Matsuo, Heike Keilhack, Fawaz G Haj   +5 more
doaj   +1 more source

The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1.

, 2006
The receptor-type protein tyrosine phosphatases (RPTPs) are integral membrane proteins composed of extracellular adhesion molecule-like domains, a single transmembrane domain, and a cytoplasmic domain.
Knapp, Stefan, Barr, A.J., Jeyanthy Eswaran, Emma Longman, Knapp, S., Stefan Knapp, Eswaran, J, Eswaran, J., Barr, AJ, Longman, E, Longman, E., Debreczeni, J.E., Judit É. Debreczeni, Alastair J. Barr, Debreczeni, JE   +14 more
core   +1 more source

Preprint: Analysis of Receptor-type Protein Tyrosine Phosphatase Extracellular Regions with Insights from AlphaFold

, 2023
The receptor-type protein tyrosine phosphatases (RPTPs) are involved in a wide variety of physiological functions which are mediated via their diverse extracellular regions.
El Badaoui, L., Barr, A.J.
core   +1 more source

CA9‐Targeted PET Imaging for Noninvasive Discrimination of Clear Cell Renal Cell Carcinoma and Associated Tumor Biological Features

Advanced Science, EarlyView.
CA9‐targeted PET imaging could be a noninvasive approach to characterize clear cell renal cell carcinoma and associated tumor biology. PET uptake correlates with tumor CA9 expression and is linked to angiogenic activity, immune remodeling, and metabolic reprogramming.
Kailei Chen, Sixuan Cheng, Jian Shi, Ruijie Liu, Yilong Wu, Xin Zheng, Xinlun Song, Yunxuan Zhang, Lei Liu, Zhihao Wei, Qi Wang, Xinwei Li, Zirui Dong, Yuenan Liu, Hongmei Yang, Xiaoli Lan, Chunxia Qin, Dawei Jiang, Keshan Wang, Xiaoping Zhang   +19 more
wiley   +1 more source

Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non–small-cell lung cancer

Tumor Biology, 2017
Acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors, such as gefitinib and erlotinib, is a critical issue in the treatment of patients with epidermal growth factor receptor mutant–positive non–small-cell lung cancer. Recent
Huake Sun, Huiwen Ma, Jianmin Wang, Liqin Xia, Guangkuo Zhu, Zhoufei Wang, Jianguo Sun, Zhengtang Chen   +7 more
doaj   +1 more source

Protein Tyrosine Phosphatase 1B in Hematopoiesis [PDF]

Cell Cycle, 2006
Protein tyrosine phosphatase 1B (PTP-1B) is a ubiquitously expressed cytosolic phosphatase best known for its role in insulin signaling. Despite the fact that it is highly expressed in hematopoietic tissues and has been shown to downregulate cytokine receptor signaling, no physiological role for PTP-1B in immune regulation had been reported. Our recent
Krista M, Heinonen, Michel L, Tremblay
openaire   +2 more sources