Results 51 to 60 of about 6,757,592 (330)
Internal protein dynamics shifts the distance to the mechanical transition state [PDF]
, 2006 Mechanical unfolding of polyproteins by force spectroscopy provides valuable insight into their free energy landscapes. Most experiments of the unfolding process have been fit to two-state and/or one dimensional models, with the details of the protein ...
Olmsted, P.D., Paci, E., West, D.K.
core +3 more sources
Studying the unfolding process of protein G and protein L under physical property space
BMC Bioinformatics, 2009 Background The studies on protein folding/unfolding indicate that the native state topology is an important determinant of protein folding mechanism.
Wang Jihua +3 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 We employed mutual information (MI) analysis to detect motions affecting the mechanical resistance of the human-engineered protein Top7. The results are based on the MI analysis of pair contact correlations measured in steered molecular dynamics (SMD ...
Ognjen Perišić, Willy Wriggers
doaj +1 more source
Proteins unfold in steps [PDF]
Proceedings of the National Academy of Sciences, 1997 I present results from an experiment on the dynamics of folding of a globular protein (bovine serum albumin). Employing a micro-mechanical technique, I perform the measurements on very few molecules (1–100). I observed a sequence of steps in time for both unfolding and refolding.
openaire +2 more sources
A protein model exhibiting three folding transitions
, 2000 We explain the physical basis of a model for small globular proteins with water interactions. The water is supposed to access the protein interior in an "all-or-none" manner during the unfolding of the protein chain.
Alex Hansen +31 more
core +1 more source
Human Frataxin Folds Via an Intermediate State. Role of the C-Terminal Region [PDF]
, 2016 The aim of this study is to investigate the folding reaction of human frataxin, whose deficiency causes the neurodegenerative disease Friedreich’s Ataxia (FRDA).
Faraj, Santiago Enrique +3 more
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Folding and Stability of Ankyrin Repeats Control Biological Protein Function
Biomolecules, 2021 Ankyrin repeat proteins are found in all three kingdoms of life. Fundamentally, these proteins are involved in protein-protein interaction in order to activate or suppress biological processes. The basic architecture of these proteins comprises repeating
Amit Kumar, Jochen Balbach
doaj +1 more source
Exploration of Protein Unfolding by Modelling Calorimetry Data from Reheating
Scientific Reports, 2017 Studies of protein unfolding mechanisms are critical for understanding protein functions inside cells, de novo protein design as well as defining the role of protein misfolding in neurodegenerative disorders.
S. Mazurenko +5 more
semanticscholar +1 more source
Out-of-equilibrium versus dynamical and thermodynamical transitions for a model protein
, 2009 Equilibrium and out-of-equilibrium transitions of an off-lattice protein model have been identified and studied. In particular, the out-of-equilibrium dynamics of the protein undergoing mechanical unfolding is investigated, and by using a work ...
Imparato, A., Luccioli, S., Torcini, A.
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Coarse-Grained Simulations of Topology-Dependent Mechanisms of Protein Unfolding and Translocation Mediated by ClpY ATPase Nanomachines. [PDF]
PLoS Computational Biology, 2016 Clp ATPases are powerful ring shaped nanomachines which participate in the degradation pathway of the protein quality control system, coupling the energy from ATP hydrolysis to threading substrate proteins (SP) through their narrow central pore ...
Andrea N Kravats +2 more
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