Results 31 to 40 of about 6,757,592 (330)
Distribution, transition and thermodynamic stability of protein conformations in the denaturant-induced unfolding of proteins. [PDF]
PLoS ONE, 2014 BACKGROUND: Extensive and intensive studies on the unfolding of proteins require appropriate theoretical model and parameter to clearly illustrate the feature and characteristic of the unfolding system. Over the past several decades, four approaches have
Liujiao Bian, Xu Ji
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Unfolded Protein Responses With or Without Unfolded Proteins? [PDF]
Cells, 2012 The endoplasmic reticulum (ER) is the site of secretory protein biogenesis. The ER quality control (QC) machinery, including chaperones, ensures the correct folding of secretory proteins. Mutant proteins and environmental stresses can overwhelm the available QC machinery.
openaire +3 more sources
Biomolecules, 2022 The spliceosome protein U1A is a prototype case of the RNA recognition motif (RRM) ubiquitous in biological systems. The in vitro kinetics of the chemical denaturation of U1A indicate that the unfolding of U1A is a two-state process but takes place via ...
Na Le Dang +2 more
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Multi-Step Unfolding and Rearrangement of α-Lactalbumin by SDS Revealed by Stopped-Flow SAXS
Frontiers in Molecular Biosciences, 2020 Interactions between proteins and surfactants are both of fundamental interest and relevant for applications in food, cosmetics and detergency. The anionic surfactant sodium dodecyl sulfate (SDS) denatures essentially all proteins. Denaturation typically
Grethe Vestergaard Jensen +6 more
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Pharmaceuticals, 2023 Exposure of many cancer cells, including multiple myeloma cells, to cytotoxic concentrations of natural products celastrol and withaferin A or synthetic compounds of the IHSF series resulted in denaturation of a luciferase reporter protein.
Nuria Vilaboa +6 more
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Development and Application of a High Throughput Protein Unfolding Kinetic Assay. [PDF]
PLoS ONE, 2016 The kinetics of folding and unfolding underlie protein stability and quantification of these rates provides important insights into the folding process.
Qiang Wang +8 more
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Funneled angle landscapes for helical proteins [PDF]
, 2020 We use crystallographic data for four helical iron proteins (cytochrome c-b₅₆₂, cytochrome c′, sperm whale myoglobin, human cytoglobin) to calculate radial and angular signatures as each unfolds from the native state stepwise though four unfolded states.
Garza-López, Roberto A. +2 more
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Thermal, chemical and pH induced denaturation of a multimeric β-galactosidase reveals multiple unfolding pathways. [PDF]
PLoS ONE, 2012 BACKGROUND: In this case study, we analysed the properties of unfolded states and pathways leading to complete denaturation of a multimeric chick pea β-galactosidase (CpGAL), as obtained from treatment with guanidium hydrochloride, urea, elevated ...
Devesh Kishore +2 more
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Communications Chemistry, 2021 Solution NMR provides an information-rich technique to monitor the unfolding process and probe the heterogeneity of protein unfolding. Differences in unfolding dynamics of core and peripheral residues during the cold denaturation of Yfh1 are followed in ...
Rita Puglisi +4 more
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Same structure, different mechanisms?
eLife, 2020 Two interpretations of similar structures for the same molecular machine illustrate the limits of inferring biochemical mechanism from protein structure.
Francis TF Tsai, Christopher P Hill
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