Results 11 to 20 of about 6,757,592 (330)
Revealing Topological Barriers against Knot Untying in Thermal and Mechanical Protein Unfolding by Molecular Dynamics Simulations [PDF]
Biomolecules, 2021 The knot is one of the most remarkable topological features identified in an increasing number of proteins with important functions. However, little is known about how the knot is formed during protein folding, and untied or maintained in protein ...
Yan Xu +4 more
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A complete picture of protein unfolding and refolding in surfactants. [PDF]
Chem Sci, 2019 Interactions between proteins and surfactants are of relevance in many applications including food, washing powder formulations, and drug formulation. The anionic surfactant sodium dodecyl sulfate (SDS) is known to unfold globular proteins, while the non-
Pedersen JN +4 more
europepmc +2 more sources
The Unfolding Tale of the Unfolded Protein Response [PDF]
Cell, 2001 Surface and secreted proteins are synthesized in the endoplasmic reticulum where they must fold and assemble before being transported. Changes in the ER that interfere with their proper maturation initiate the unfolded protein response pathway. New studies have filled in a missing link between the yeast and mammalian pathways.
Ma, Yanjun, Hendershot, Linda M.
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Role of the membrane potential in mitochondrial protein unfolding and import. [PDF]
Sci Rep, 2019 Newly synthesized mitochondrial precursor proteins have to become unfolded to cross the mitochondrial membranes. This unfolding is achieved primarily by mitochondrial Hsp70 (mtHsp70) for presequence-containing precursor proteins.
Sato TK, Kawano S, Endo T.
europepmc +2 more sources
HOPS-Dependent Endosomal Escape Demands Protein Unfolding [PDF]
ACS Central ScienceMadeline Zoltek +5 more
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Pharmaceutics, 2022 Pharmaceutical proteins, compared to small molecular weight drugs, are relatively fragile molecules, thus necessitating monitoring protein unfolding and aggregation during production and post-marketing.
Jaakko Itkonen +5 more
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Unfolded protein response [PDF]
Current Biology, 2012 SummaryIn eukaryotic cells, the endoplasmic reticulum (ER) is a membrane-enclosed interconnected organelle responsible for the synthesis, folding, modification, and quality control of numerous secretory and membrane proteins. The processes of protein folding and maturation are highly assisted and scrutinized but are also sensitive to changes in ER ...
Cao, Stewart Siyan, Kaufman, Randal J.
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Biochemistry and Biophysics Reports, 2021 Although unfolding of protein in the liquid state is relatively well studied, its mechanisms in the solid state, are much less understood. We evaluated the reversibility of thermal unfolding of lysozyme with respect to the water content using a ...
Tuan Phan-Xuan +6 more
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Thermal unfolding of proteins [PDF]
The Journal of Chemical Physics, 2005 Thermal unfolding of proteins is compared to folding and mechanical stretching in a simple topology-based dynamical model. We define the unfolding time and demonstrate its low-temperature divergence. Below a characteristic temperature, contacts break at separate time scales and unfolding proceeds approximately in a way reverse to folding.
Cieplak, Marek, Sulkowska, Joanna I.
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Chemical and thermal unfolding of a global staphylococcal virulence regulator with a flexible C-terminal end. [PDF]
PLoS ONE, 2015 SarA, a Staphylococcus aureus-specific dimeric protein, modulates the expression of numerous proteins including various virulence factors. Interestingly, S.
Avisek Mahapa +6 more
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